Sleep-Related Headache and its Management

Singh, Niranjan; Sahota, Pradeep

doi:10.1007/s11940-013-0258-1

Cited by 46 publications

(29 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some forms of headache such as migraine, cluster headache, and the hypnic headache are associated with the sleep-wake cycle [17,160,161]. Adenosine plays a critical role in circadian rhythms [162].…”

Section: The Role Of Adenosine In Common Forms Of Headachementioning

confidence: 99%

The Role of Adenosine Signaling in Headache: A Review

2017

View full text Add to dashboard Cite

Migraine is the third most prevalent disease on the planet, yet our understanding of its mechanisms and pathophysiology is surprisingly incomplete. Recent studies have built upon decades of evidence that adenosine, a purine nucleoside that can act as a neuromodulator, is involved in pain transmission and sensitization. Clinical evidence and rodent studies have suggested that adenosine signaling also plays a critical role in migraine headache. This is further supported by the widespread use of caffeine, an adenosine receptor antagonist, in several headache treatments. In this review, we highlight evidence that supports the involvement of adenosine signaling in different forms of headache, headache triggers, and basic headache physiology. This evidence supports adenosine A2A receptors as a critical adenosine receptor subtype involved in headache pain. Adenosine A2A receptor signaling may contribute to headache via the modulation of intracellular Cyclic adenosine monophosphate (cAMP) production or 5' AMP-activated protein kinase (AMPK) activity in neurons and glia to affect glutamatergic synaptic transmission within the brainstem. This evidence supports the further study of adenosine signaling in headache and potentially illuminates it as a novel therapeutic target for migraine.

show abstract

Section: The Role Of Adenosine In Common Forms Of Headachementioning

confidence: 99%

The Role of Adenosine Signaling in Headache: A Review

2017

View full text Add to dashboard Cite

show abstract

“…4 Both forms of migraine can present with medical, neurologic, and psychiatric comorbidities that may exacerbate the disease, complicate treatment, and reduce health-related quality of life. Sleep disorders are often discussed 5,6 but less commonly studied comorbidities of migraine and incorporate a wide range of conditions, including but not limited to sleep apnea, insomnia, circadian rhythm (ie, sleep-wake) disorders, and sleep movement disorders.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disorders Among People With Migraine: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study

et al. 2018

View full text Add to dashboard Cite

Objectives.— We examined the cross-sectional association of sleep apnea and indices of sleep quality with both episodic migraine (EM) and chronic migraine (CM). Background.— Sleep apnea and abnormal patterns of sleep, such as insomnia, were associated with migraine onset, severity, and progression in previous research. Methods.— The Chronic Migraine Epidemiology & Outcomes Study, a longitudinal study, used a series of web-based surveys to assess migraine symptoms, burden, and patterns of health care utilization. Quota sampling was used from September 2012 to November 2013 to generate a representative sample of the US population. Persons who screened positive for sleep apnea on the Berlin Questionnaire are said to be at “high risk” for sleep apnea. Respondents indicated if they believed that they had sleep apnea, if a physician had diagnosed it, and if and how they were treated. Other aspects of sleep quality were assessed using the Medical Outcomes Study (MOS) Sleep Measures. Results.— Of 12,810 eligible respondents with migraine and data on sleep, 11,699 with EM (91.3%) and 1111 with CM (8.7%) provided valid data for this analyses. According to the Berlin Questionnaire, 4739/12,810 (37.0%) were at “high risk” for sleep apnea, particularly persons with CM vs EM (575/1111 [51.8%] vs 4164/11,699 [35.6%]), men vs women (1431/3220 [44.4%] vs 3308/9590 [34.5%]), people with higher body mass index, and older people (all P < .001). Among respondents to the MOS Sleep Measures, persons with CM were more likely to report poor sleep quality than those with EM, including sleep disturbance (mean [SD] values: 53.2 [26.9] vs 37.9 [24.3]), snoring (38.0 [33.9] vs 31.0 [32.1]), shortness of breath (34.9 [29.8] vs 15.3 [20.6]), somnolence (44.1 [23.4] vs 32.2 [21.2]), and less likely to report sleep adequacy (34.0 [24.2] vs 39.2 [22.1]). Conclusions.— Compared with respondents with EM, a larger proportion of those with CM were at “high risk” for sleep apnea and reported poor sleep quality. This reflects an association between CM vs EM and sleep apnea and poor sleep quality; the potential relationships are discussed.

show abstract

“…Benzodiazepine was used in 15 patients in order to treat insomnia. It is known that chronic tension-type headache has high prevalence of insomnia which can require medication 33. Although benzodiazepines (BZDs) play a role in the management of headache disorders,34 medical personnel should be aware about the risk of dependence and headache related to BZDs abuse 35…”

Section: Discussionmentioning

confidence: 99%

The challenge of managing headache disorders in a tertiary referral neurology clinic in Rwanda

Kaputu-Kalala-Malu

Walker

Ntumba-Tshitenge

et al. 2016

NSJ

View full text Add to dashboard Cite

Objective:To determine the pattern, management, and outcome of headaches among patients treated at Outpatient Neurology Clinic.Methods:A retrospective study was conducted at the Out-Patient Neurology Clinic of the Butare University Teaching Hospital, University of Rwanda, Butare, Rwanda between February and May 2015. We extracted the demographic data, headache characteristics, and associated conditions, prior pain-relieving medication use, waiting time before consultation, the results of paraclinical investigations, final diagnosis according to the International Classification of Headache Disorders, management, and 3-month clinical outcome from the medical records of all patients who consulted for headache over 36-month period. Epi Data and Statistical package for Social sciences software version 21.0 (SPSS Inc, Chicago, IL, USA) software were used for data processing.Results:Headache disorders represent a quarter of all neurological consultations. Patients were predominantly female (67%) and young (78% <45 years old). One-third (34%) presented with chronic tension-type headache. Neuroimaging demonstrated an abnormality in a significant minority (14%). Amitriptyline was the most commonly used drug (60%) in management. Forty percent of those patients followed for 3 months did not experience any clinical improvement.Conclusion:Headache is among the most common medical complaints in the Outpatient Neurology Clinic, with a wide array of underlying diagnoses, and a significant yield on neuroimaging. A significant proportion of those suffering from headache disorders have poor short-term outcomes. Novel approaches, such as headache support groups and alternative pharmacological agents, should be investigated for these patients.

show abstract

Sleep-Related Headache and its Management

Cited by 46 publications

References 59 publications

The Role of Adenosine Signaling in Headache: A Review

The Role of Adenosine Signaling in Headache: A Review

Sleep Disorders Among People With Migraine: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study

The challenge of managing headache disorders in a tertiary referral neurology clinic in Rwanda

Contact Info

Product

Resources

About