Sleep‐Related Disorders in Children with Attention‐Deficit Hyperactivity Disorder: Preliminary Results of a Full Sleep Assessment Study

Miano, Silvia; Esposito, Maria; Foderaro, Giuseppe; Ramelli, Gian Paolo; Pezzoli, Valdo; Manconi, Mauro

doi:10.1111/cns.12573

Cited by 40 publications

(27 citation statements)

References 50 publications

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“…Iron deficiency may also cause restless leg syndrome, which in turn may lead to ADHD. [ 9 10 ] ADHD is a treatable cause of many future problems such as educational difficulty, social exclusion, school dropout, and criminality.…”

Section: Introductionmentioning

confidence: 99%

A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center

Islam

Seth

Saha

et al. 2018

Indian J Psychiatry

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Background:Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD).Aims:As studies are scarce in the Indian context, we had undertaken this study to find out the association between iron deficiency and ADHD.Settings and Design:Hospital-based cross-sectional study.Materials and Methods:Hematological parameters indicating iron status (hemoglobin [Hb], ferritin, Iron, total iron binding capacity [TIBC], mean corpuscular volume [MCV], and mean corpuscular Hb [MCH]) were measured among 119 ADHD patients selected by complete enumeration method and 119 controls.Statistical Analysis:Shapiro–Wilk test, Mann–Whitney U-test, Spearman's correlation, and binary logistic regression were used. P < 0.01 was taken as statistically significant.Results:Hb, iron, ferritin, MCV, and MCH were lower among cases and negatively correlated to ADHD, while reverse is true for TIBC and ADHD. Iron deficiency anemia makes one 3.82 times more prone for ADHD.Conclusion:Iron deficiency was associated with ADHD.

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Section: Introductionmentioning

confidence: 99%

A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center

Islam

Seth

Saha

et al. 2018

Indian J Psychiatry

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“…These limb movements can disrupt sleep and may trigger or worsen symptoms of ADHD. [21][22][23] The cardiovascular risk posed by transient surges in blood pressure and heart rate associated with the leg movement events has been documented in studies involving adult patients with PLMS, with many of such patients being also diagnosed with RLS. Children with hypertension were twice as likely to have PLMS.…”

Section: The Conundrum Of Periodic Limb Movementsmentioning

confidence: 99%

Restless Legs Syndrome and Periodic Limb Movement Disorder in Children

Sharon

Walters

Simakajornboon

2019

JCS

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Introduction Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) have been studied more than any other sleep-related movement disorder in the pediatric population. A common feature to both, periodic limb movements, occurs in many other disorders and also in reportedly healthy children and adolescents. In this review, we discuss the different types of limb movements as it pertains to pediatric RLS and PLMD and provides an update on these disorders. Methods A literature search was performed with the following inclusion criteria: English publication, limb movements, leg movements, periodic limb movements of sleep, periodic limb movements during wake, PLMD, RLS, with each of the modifiers, children, pediatric, and adolescents. Identified publications were reviewed and their reference lists were searched for additional relevant publications. Results A total of 102 references were included in this review. These included epidemiological studies, prospective and retrospective studies, case series, observational data, reviews, and consensus guidelines. A critical summary of these findings is presented. Conclusion The limited evidence-based data support the importance of evaluating limb movements in the context of the clinical symptomatology presented by the child or the adolescent. Further research is needed to (1) better understand the pathophysiological mechanisms resulting in periodic limb movements as encountered in the pediatric PLMD or RLS patient and their impact on the overall health and well-being, (2) develop objective diagnostic criteria for RLS and differentiate it from its “mimics” in the pediatric population, and (3) establish evidence-based guidelines for treatment.

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“…The most common complaint is sleep-onset insomnia, and rarely, sleep problems are related to a delayed sleep phase syndrome. Also, SDB is highly associated with disturbed attention and hyperactivity, and children with SDB are more sensitive to oxidative stress [61][62][63].…”

Section: Melatonin In Attention-deficit/hyperactivity Disorder (Adhd)mentioning

confidence: 99%

“…Based on trials conducted in this population, melatonin treatment in doses ranging between 3 and 6 mg/day may reduce sleep-onset delay and increased sleep duration time [61][62][63].…”

Section: Melatonin In Attention-deficit/hyperactivity Disorder (Adhd)mentioning

confidence: 99%

Melatonin in Childhood Epilepsy and in Child Neurology

Paprocka¹,

Kijonka²,

Sokół³

2018

Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches

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Melatonin (MLT) was isolated as a hormone by Lerner in 1958, and since then, intense studies have been under way with respect to its action and possibilities of application in various fields of medicine. Despite the existence of multiple antiepileptic medications and progress that has taken place in neurosurgical treatment of epilepsy, drug-resistant epilepsy continues to be a phenomenon that occurs in 30-35% children treated for epileptic seizures. Reports presented in the study have shown that children with epilepsy suffer from sleep disorders. Sleep deprivation may cause seizures, and on the other hand, an increased frequency of seizures may lead to sleep disturbances.

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Sleep‐Related Disorders in Children with Attention‐Deficit Hyperactivity Disorder: Preliminary Results of a Full Sleep Assessment Study

Abstract: Our study further highlights the need to design an efficient sleep diagnostic algorithm for children with ADHD, thereby more accurately identifying cases in which a full sleep assessment is indicated.

Cited by 40 publications

References 50 publications

A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center

A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center

Restless Legs Syndrome and Periodic Limb Movement Disorder in Children

Melatonin in Childhood Epilepsy and in Child Neurology

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