Sleep-related disordered breathing in children with syndromic craniosynostosis

Al-Saleh, Suhail; Riekstins, Andrea; Forrest, Christopher R.; Philips, John H.; Gibbons, Jeremy; Narang, Indra

doi:10.1016/j.jcms.2010.04.011

Cited by 53 publications

(19 citation statements)

References 48 publications

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“…The high prevalence is in line with the high prevalence of OSAS reported by Al-Saleh and coauthors in a recent study 24. In former studies, it was found to be around 40% 3 4.…”

Section: Discussionsupporting

confidence: 89%

How does obstructive sleep apnoea evolve in syndromic craniosynostosis? A prospective cohort study

Driessen

Joosten

Bannink

et al. 2013

Archives of Disease in Childhood

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OSAS is highly prevalent in syndromic craniosynostosis. There is some natural improvement, mainly during the first 3 years of life and least in children with Apert or Crouzon/Pfeiffer syndrome. In the absence of other co-morbid risk factors, it is highly unlikely that if severe OSAS is not present early in life it will develop during childhood. Ongoing clinical surveillance is of great importance and continuous monitoring for the development of other co-morbid risk factors for OSAS should be warranted.

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“…The high prevalence is in line with the high prevalence of OSAS reported by Al-Saleh and coauthors in a recent study 24. In former studies, it was found to be around 40% 3 4.…”

Section: Discussionsupporting

confidence: 89%

How does obstructive sleep apnoea evolve in syndromic craniosynostosis? A prospective cohort study

Driessen

Joosten

Bannink

et al. 2013

Archives of Disease in Childhood

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“…The Canadian experience has been very similar, with 26 of 35 (74%) patients with syndromic craniosynostosis referred to a pediatric sleep clinic (mean age: 4.5 years) having OSA (13). 16 were treated with either adenotonsillectomy, cranial vault surgery, maxillary surgery or CPAP.…”

Section: Craniosynostosis and Osamentioning

confidence: 98%

Craniofacial syndromes and sleep-related breathing disorders

Tan

Kheirandish‐Gozal

Abel

et al. 2016

Sleep Medicine Reviews

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Summary Children with craniofacial syndromes are at risk of sleep disordered breathing, the most common being obstructive sleep apnea. Midface hypoplasia in children with craniosynostosis and glossoptosis in children with Pierre Robin syndrome are well recognized risk factors, but the etiology is often multifactorial and many children have multilevel airway obstruction. We examine the published evidence and explore the current management strategies in these complex patients. Some treatment modalities are similar to those used in otherwise healthy children such as as adenotonsillectomy, positive pressure ventilation and in the refractory cases, tracheostomy. However, there are some distinct approaches such as nasopharyngeal airways, tongue lip adhesion, mandibular distraction osteogenesis in children with Pierre Robin sequence, and midface advancement in children with craniosynostoses. Clinicians should have a low threshold for referral for evaluation of sleep-disordered-breathing in these patients.

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“…12,13 This wide range is attributable in part to different event definition criteria and measurement methodology, with few studies using polysomnography as the main outcome. Our prevalence was in the higher range, with more than three-quarters (83 percent) of our sample having obstructive sleep apnea syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11] Children with syndromic craniosynostosis (Apert, Crouzon, and Pfeiffer syndromes) are prone to obstructive sleep apnea syndrome, with a reported prevalence between 40 and 85 percent. [12][13][14] These children have multiple congenital craniofacial abnormalities because of premature fusion of one or more cranial sutures and share a genetic mutation in the fibroblast growth factor receptor 1, 2, or 3 gene. 15 The cause of obstructive sleep apnea syndrome in these children is multifactorial: premature fusion of sutures causes midfacial hypoplasia, increased nasopharyngeal resistance, and a narrowed oropharyngeal space; central nervous system abnormalities (i.e., restricted brain growth, increased intracranial pressure and Chiari malformations) 16,17 may cause neuromuscular control instability of airway patency and central apnea; and other congenital malformations deleteriously affect the upper airway such as cleft palate, choanal atresia, and tracheal abnormalities.…”

mentioning

confidence: 99%

“…22 Al-Saleh et al also examined the prevalence of obstructive sleep apnea syndrome in this population but only had preoperative and postoperative adenotonsillectomy polysomnographic data in one child. 12 To answer the question of whether adenotonsillectomy is effective treatment for obstructive sleep apnea in children with syndromic craniosynostosis, we documented the prevalence, severity, and progression of obstructive sleep apnea syndrome as measured by polysomnography before and after adenotonsillectomy in our cohort of patients. Understanding the natural course of obstructive sleep apnea syndrome in these children, and the response to adenotonsillectomy, will provide insights into appropriate screening protocols and aid with management strategies for obstructive sleep apnea syndrome.…”

mentioning

confidence: 99%

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