Sleep-Related Breathing Disorders and Lung Transplantation

Voth, Ana R. Hernández; Mañas, Pedro D. Benavides; Gafas, Alicia de Pablo; Rodríguez, María J. Díaz de Atauri

doi:10.1097/tp.0000000000000600

Cited by 11 publications

(14 citation statements)

References 14 publications

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“…High prevalence at 12 months post‐LTX was also shown in a study that evaluated 20 patients before, at 6 and 12 months post‐LTX. This study showed that SDB prevalence was high at 6 months post‐LTX and remained high at 12 months post‐LTX 12 …”

Section: Discussionmentioning

confidence: 61%

“…Yet, there is a high variability in reported prevalence. Prevalence of SDB after LTX was not significantly increased at 1 month after LTX but was increased at 6 months and 1 year after LTX 12,13 …”

Section: Introductionmentioning

confidence: 97%

“…Little is known about the exact pathophysiology of SDB after LTX. A substantial proportion of LTX recipients were overweight, which could contribute to SDB development 12,14 . Other possible mechanisms are changes in respiratory drive due to altered chemosensitivity eventually induced by lung denervation affecting control of breathing and use of specific drugs including opiates and immune suppressive agents 9,12 …”

Section: Introductionmentioning

confidence: 99%

“…Prevalence of SDB after LTX was not significantly increased at 1 month after LTX but was increased at 6 months and 1 year after LTX. 12,13 Little is known about the exact pathophysiology of SDB after LTX. A substantial proportion of LTX recipients were overweight, which could contribute to SDB development.…”

mentioning

confidence: 99%

“…A substantial proportion of LTX recipients were overweight, which could contribute to SDB development. 12,14 Other possible mechanisms are changes in respiratory drive due to altered chemosensitivity eventually induced by lung denervation affecting control of breathing and use of specific drugs including opiates and immune suppressive agents. 9,12 This study aimed to evaluate SDB prevalence and its associated factors such as anthropometrics, underlying disease, and biochemical and lung function parameters at 1 year after LTX in a large cohort.…”

mentioning

confidence: 99%

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Sleep-disordered breathing after lung transplantation: An observational cohort study

Testelmans

Schoovaerts

Belge

et al. 2021

American Journal of Transplantation

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Sleep-disordered breathing (SDB) describes a number of disorders, characterized by partial or complete cessation of breathing during sleep, with obstructive sleep apnea (OSA) being the most common form of SDB. SDB prevalence is increasing over the last decades because of increasing prevalence of obesity, improvement in diagnostic methods, and aging of the population. 1 The prevalence of moderate to severe SDB (defined as apnea-hypopnea index ≥ 15/h of sleep) in Belgium is estimated to be 15.7%. 2 Different studies have shown a strong link between the presence of SDB and cardiovascular morbidity and mortality. 3,4 Lung transplantation (LTX) is an effective and important treatment option for selected patients with a variety of end-stage

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Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Sleep-disordered breathing after lung transplantation: An observational cohort study

Testelmans

Schoovaerts

Belge

et al. 2021

American Journal of Transplantation

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Influence of Sleep-Disordered Breathing on Quality of Life and Exercise Capacity in Lung Transplant Recipients

Kruse

Kleibrink

Rabis

et al. 2019

Advances in Pulmonary Medicine: Research and Innovations

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The Evaluation and Therapeutic Management of Hypertension in the Transplant Patient

Thomas

Weir

2015

Curr Cardiol Rep

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Organ transplantation is the therapeutic option of choice in the appropriate patient with end-organ disease. A major comorbidity after the transplant is the development of hypertension which is a risk factor for cardiovascular disease. Cardiovascular disease is the most common cause of death in this population even when there is a functioning graft. It is essential to evaluate post-transplant hypertension not only in the office setting but at home and at night as well. Hence, the use of 24-h ambulatory blood pressure monitoring in both diagnosis and long-term care of this patient population is paramount. Factors involved in uncontrolled hypertension include the donor, recipient, and those specific to the transplant such as immunosuppressive drug exposure. The major offending immunosuppressive agents belong to the calcineurin inhibitor class. The therapy of post-transplant hypertension involves pharmaceutical and non-pharmaceutical interventions that should be tailored to the specific patient and type of transplant. There is clearly a need for more definitive data and quality studies in both the renal and non-renal transplant populations.

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Sleep-Related Breathing Disorders and Lung Transplantation

Abstract: We have observed a significant prevalence of obstructive sleep apnea syndrome in patients in waiting list for LT, and LT has an important influence in the evolution of the disorder. In our series, LT has somehow affected the stability of upper airway and ventilatory mechanics.

Cited by 11 publications

References 14 publications

Sleep-disordered breathing after lung transplantation: An observational cohort study

Sleep-disordered breathing after lung transplantation: An observational cohort study

Influence of Sleep-Disordered Breathing on Quality of Life and Exercise Capacity in Lung Transplant Recipients

The Evaluation and Therapeutic Management of Hypertension in the Transplant Patient

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