Sleep Quality, Depression, and Quality of Life After Bilateral Anodal Transcranial Direct Current Stimulation in Patients with Parkinson’s Disease

Hadoush, Hikmat; Al‐Sharman, Alham; Khalil, Hanan; Banihani, Saleem Ali; Al-Jarrah, Muhammed

doi:10.12659/msmbr.911411

Cited by 21 publications

(21 citation statements)

References 39 publications

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“…One study tested in both off and on dopaminergic medication [ 33 ], one tested in the off state [ 49 ], and one did not report medication status [ 52 ]. Five investigations had open-label designs [ 38 , 43 , 45 , 46 , 47 ]; seven were parallel arm, randomized, double-blind, sham-controlled designs [ 33 , 40 , 41 , 42 , 44 , 50 , 52 ]; and eight were crossover, randomized, sham-controlled designs, with six being double-blind [ 36 , 37 , 39 , 48 , 49 , 51 ] and two with unstated blinding [ 34 , 35 ]. The tDCS intensities ranged from 1 to 2.8 mA (range of current densities = 0.02 mA/cm 2 –0.12 mA/cm 2 ) and stimulation was applied for 7–30 min (mode = 20 min).…”

Section: Resultsmentioning

confidence: 99%

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

2020

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Transcranial direct current stimulation (tDCS) is accompanied by transient sensations (e.g., tingling, itching, burning), which may affect treatment outcomes or break the blinding of the study protocol. Assessing tolerability and blinding is integral to providing ample evidence of a “real effect” from the applied stimulation and dispelling the possibility of placebo effects. People with Parkinson’s disease (PwPD) endure many motor and non-motor symptoms that might be amenable to tDCS. However, because the disease also affects sensation capabilities, these subjects might report tolerability and blinding differently than other cohorts. Therefore, the purpose of this review was to aggregate the tolerability and blinding reports of tDCS studies in PwPD and recommend a standard tolerability and blinding reporting practice. A literature search of the PubMed and Scopus databases from 1 January 2020 to 1 April 2020 was performed to identify publications that applied tDCS to PwPD. Seventy studies were potentially reviewable, but only 36 (nine with quantitative tolerability reports, 20 with qualitative tolerability reports, and seven that only reported blinding) provided sufficient information to be included in the review. Quantitative information on tDCS tolerability and blinding maintenance in PwPD is scarce, and future reviews and metanalyses should carefully consider the possibility of placebo effects in their included studies.

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Section: Resultsmentioning

confidence: 99%

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

2020

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“…• Gait and balance (Benninger et al, 2010;Verheyden et al, 2013;Capecci et al, 2014;Kaski et al, 2014a;Mak and Yu, 2014;Manenti et al, 2014;Valentino et al, 2014;Costa-Ribeiro et al, 2016Schabrun et al, 2016;Swank et al, 2016;Fernandez-Lago et al, 2017;Lattari et al, 2017;Criminger et al, 2018;da Silva et al, 2018;Dagan et al, 2018;Harris et al, 2018;Yotnuengnit et al, 2018;Alizad et al, 2019;Putzolu et al, 2019) • Upper limb function (Fregni et al, 2006;Benninger et al, 2010;Doruk et al, 2014;Salimpour et al, 2015;Costa-Ribeiro et al, 2016;Ferrucci et al, 2016;Schabrun et al, 2016;Cosentino et al, 2017;Ishikuro et al, 2018;Broeder et al, 2019) • Cognition (Nitsche et al, 2005;Boggio et al, 2006;Biundo et al, 2015;Manenti et al, 2016;Elder et al, 2017;Lawrence et al, 2018;Adenzato et al, 2019) • Impulsive pathological gambling behavior (Benussi et al, 2017a) • Speech (Pereira et al, 2013) • Sleep (Hadoush et al, 2018) • Fatigue …”

Section: Mode Of Tesmentioning

confidence: 99%

“…Sleep disturbance is a common non-motor symptom in patients with PD, adversely affecting their overall quality of life and promoting neuropsychiatric complications like depression (Kay et al, 2018). Bilateral anodal tDCS simultaneously over the left and the right prefrontal and motor areas (10 sessions, 20 min each, five sessions per week) improved their Pittsburgh Sleep Quality Index total score, sleep latency sub-score, Geriatric Depression Scale total score, and physical and mental component scores of the health-related quality-of-life questionnaire (SF-36) (Hadoush et al, 2018). A beneficial effect of bilateral DLPFC tDCS (eight sessions, 0.06 mA/cm 2 current, 20 min/session) on fatigue in PD patients, using left anodal and right cathodal stimulation, has been shown by Forogh et al (2017) when combined with occupational therapy.…”

Section: (E) Effect On Speechmentioning

confidence: 99%

Non-invasive Transcranial Electrical Stimulation in Movement Disorders

et al. 2020

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Dysfunction within large-scale brain networks as the basis for movement disorders is an accepted hypothesis. The treatment options for restoring network function are limited. Non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation are now being studied to modify the network. Transcranial electrical stimulation (tES) is also a portable, cost-effective, and non-invasive way of network modulation. Transcranial direct current stimulation and transcranial alternating current stimulation have been studied in Parkinson's disease, dystonia, tremor, and ataxia. Transcranial pulsed current stimulation and transcranial random noise stimulation are not yet studied enough. The literature in the use of these techniques is intriguing, yet many unanswered questions remain. In this review, we highlight the studies using these four potential tES techniques and their electrophysiological basis and consider the therapeutic implication in the field of movement disorders. The objectives are to consolidate the current literature, demonstrate that these methods are feasible, and encourage the application of such techniques in the near future. Keywords: non-invasive brain stimulation (NIBS), transcranial electrical stimulation (tES), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial pulsed current stimulation (tPCS), transcranial random noise stimulation (tRNS)

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“…Also, the evidence suggests that tDCS might affect sleep quality and neurocognition in euthymia and is useful for relapse prevention [18]. Besides, bilateral anodal tDCS stimulation for 10 sessions (20 min each, 5 per week) demonstrated potential therapeutic effects on depression level improvement and sleep quality in patients with Parkinson disease [19].…”

Section: Introductionmentioning

confidence: 99%

“…The direct effect of tDCS stimulation and the indirect impact on sleep quality may be favorable in subjects under MMT through bilateral anodal stimulation, over DLPFC (dorsolateral prefrontal cortex), premotor, and M1 areas. Also, tDCS can change the cortical excitability and increases brain excitability by altering the resting potential of cortical neural cells [19,21]. The safety of tDCS in adults has been well documented and confirmed, and several reported side effects were mild and transient.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Therapeutic Effects of Transcranial Direct Current Stimulation on Sleep Quality Among Patients Under Methadone Maintenance Treatment

Bimorgh

Omidi

Ghoreishi

et al. 2020

Int J Med Toxicol Forensic Med

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Background: Patients under Methadone Maintenance Therapy (MMT) are susceptible to several problems, including sleep disturbances and risk of relapse. The present study aimed to assess the effect of transcranial direct current stimulation (tDCS) on sleep quality of addicts under MMT.Methods: This clinical trial was conducted on 27 male patients who underwent maintenance methadone therapy in MMT clinics of Mashhad City, Iran. They were divided into the experimental and sham groups. The experimental group received seven 20-min sessions of tDCS every other day. In the sham group, the electrical current was delivered for a few seconds, but the electrodes were remained to the end of the session. Sleep quality was measured at baseline, during, and after the intervention by Pittsburg Sleep Quality Index (PSQI). The obtained data were analyzed by descriptive statistics such as mean and standard deviation and inferential statistics, such as t test, Chi-square, Mann Whitney, and Fischer exact test in SPSS v. 25.Results: The difference between the two groups after tDCS in sleep duration was significant (P=0.04). In the experimental group, the total score of sleep had a reducing trend (P<0.000), while in the sham group, the overall score in 3 phases of evaluation had no significant change (P=0.19). However, the rate of inappropriate sleep quality was not significant between the two groups after the intervention (P=0.12).Conclusion: This trial demonstrated the positive effect of tDCS on sleep quality in patients under MMT programs. Further studies are needed to confirm our findings.

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Sleep Quality, Depression, and Quality of Life After Bilateral Anodal Transcranial Direct Current Stimulation in Patients with Parkinson’s Disease

Cited by 21 publications

References 39 publications

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

Non-invasive Transcranial Electrical Stimulation in Movement Disorders

Exploring the Therapeutic Effects of Transcranial Direct Current Stimulation on Sleep Quality Among Patients Under Methadone Maintenance Treatment

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