Sleep quality and neuropsychological functioning in bipolar I disorder

Menkes, Margo W.; Andrews, Carolyn M.; Burgess, Helen J.; Carley, Isabel; Marshall, David F.; Langenecker, Scott A.; McInnis, Melvin G.; Deldin, Patricia; Ryan, Kelly A.

doi:10.1016/j.jad.2021.06.022

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…The inverse association of mentally active sedentary behavior, a type of intellectual stimulation, and cognition in later-life participants is also in line with our earlier UK Biobank study in which we found that BD and control participants with less mentally active sedentary behavior were less protected against putative cognitive decline (Ringin et al, 2023). Regarding sleep, preliminary BD research has linked sleep abnormalities with attention and processing speed impairments, although none have examined this association as a function of age (Bradley et al, 2020;Burgess et al, 2022;Kanady, Soehner, Klein, & Harvey, 2017;Laskemoen et al, 2020;Menkes et al, 2021;Russo et al, 2015). Nonetheless, meta-analytic data from the general population has shown a negative association of short and long sleep duration with multi-domain cognitive performance, executive functions, verbal, and working memory during later-life (Lo, Groeger, Cheng, Dijk, & Chee, 2016).…”

Section: Discussionsupporting

confidence: 85%

Relative associations of behavioral and physiological risks for cardiometabolic disease with cognition in bipolar disorder during mid and later-life: findings from the UK biobank

Ringin,

Dunstan,

Meyer

et al. 2024

Psychol. Med.

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Background Cardiometabolic disease risk factors are disproportionately prevalent in bipolar disorder (BD) and are associated with cognitive impairment. It is, however, unknown which health risk factors for cardiometabolic disease are relevant to cognition in BD. This study aimed to identify the cardiometabolic disease risk factors that are the most important correlates of cognitive impairment in BD; and to examine whether the nature of the relationships vary between mid and later life. Methods Data from the UK Biobank were available for 966 participants with BD, aged between 40 and 69 years. Individual cardiometabolic disease risk factors were initially regressed onto a global cognition score in separate models for the following risk factor domains; (1) health risk behaviors (physical activity, sedentary behavior, smoking, and sleep) and (2) physiological risk factors, stratified into (2a) anthropometric and clinical risk (handgrip strength, body composition, and blood pressure), and (2b) cardiometabolic disease risk biomarkers (CRP, lipid profile, and HbA1c). A final combined multivariate regression model for global cognition was then fitted, including only the predictor variables that were significantly associated with cognition in the previous models. Results In the final combined model, lower mentally active and higher passive sedentary behavior, higher levels of physical activity, inadequate sleep duration, higher systolic and lower diastolic blood pressure, and lower handgrip strength were associated with worse global cognition. Conclusions Health risk behaviors, as well as blood pressure and muscular strength, are associated with cognitive function in BD, whereas other traditional physiological cardiometabolic disease risk factors are not.

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Section: Discussionsupporting

confidence: 85%

Relative associations of behavioral and physiological risks for cardiometabolic disease with cognition in bipolar disorder during mid and later-life: findings from the UK biobank

Ringin,

Dunstan,

Meyer

et al. 2024

Psychol. Med.

View full text Add to dashboard Cite

show abstract

“…Regarding sleep, preliminary BD research has linked sleep abnormalities with cognitive impairment, although none have examined this association as a function of age (Bradley et al, 2020;Burgess et al, 2022;Kanady, Soehner, Klein, & Harvey, 2017;Laskemoen et al, 2020;Menkes et al, 2021;Russo et al, 2015). Nonetheless, meta-analytic data from the general population has shown an negative association of short and long sleep duration with cognition during later-life (Lo, Groeger, Cheng, Dijk, & Chee, 2016).…”

Section: Discussionmentioning

confidence: 99%

Relative Associations of Behavioural and Physiological Risks for Cardiometabolic Disease with Cognition in Bipolar Disorder: Findings from the UK Biobank

Ringin,

Dunstan,

Meyer

et al. 2023

Preprint

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Background: Cardiometabolic disease risk factors are disproportionately prevalent in bipolar disorder (BD) and are associated with cognitive impairment. It is, however, unknown which health risk factors for cardiometabolic disease are relevant to cognition in BD. This study aimed to identify the cardiometabolic disease risk factors that are the most important correlates of cognitive impairment in BD; and to examine whether the nature of the relationships vary between mid and later life.Methods: Data from the UK Biobank were available for 966 participants with BD. Individual cardiometabolic disease risk factors were initially regressed onto a global cognition score in separate models for the following risk factor domains; 1) health risk behaviours (physical activity, sedentary behaviour, smoking, sleep) and 2) physiological risk factors, stratified into 2a) anthropometric and clinical risk (handgrip strength, body composition, blood pressure), and 2b) cardiometabolic disease risk biomarkers (CRP, lipid profile). A final combined multivariate regression model for global cognition was then fitted, including only the predictor variables that were significantly associated with cognition in the previous models.Results: In the final combined model, lower mentally-active and higher passive sedentary behaviour, higher levels of physical activity, inadequate sleep duration, higher systolic and lower diastolic blood pressure, and lower handgrip strength were associated with worse global cognition. Conclusions: Health risk behaviours, as well as blood pressure and muscular strength, are associated with cognitive function in BD, whereas other traditional physiological cardiometabolic disease risk factors are not.

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“…Circadian clock-deficient cryptochrome knockout mice present with cognitive dysfunction and elevated anxiety [ 66 ]. Poor sleep quality is found related to poorer neuropsychological functioning in bipolar I disorder [ 67 ]. With RDoC highlighting circadian rhythm and cognitive evaluation in arousal/modulatory system and cognitive system separately, we can’t help speculating the role of circadian rhythm in neurocognitive impairment of BD, where we seek to better understand the correlation of circadian rhythm and neurocognitive functioning [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Can circadian rhythm predict changes in neurocognitive functioning in bipolar disorder: protocol of a 12-month longitudinal cohort study based on research domain criteria

Wang

Zhang

et al. 2023

Annals of Medicine

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Introduction: Bipolar disorder (BD) is a prevalent and disabling mental disorder characterized by disrupted circadian rhythms and impaired neurocognitive features, both of which fall under the major domains of Research Domain Criteria (RDoC). However, there is limited evidence regarding the interaction between circadian rhythms and long-term neurocognitive functioning. Therefore, this longitudinal cohort study protocol aims to explore whether circadian rhythm can predict changes in neurocognitive functioning over time in patients with BD. Methods: This study adopts a longitudinal cohort design, aiming to recruit 100 BD patients in either depressive or remitted states. Participants will undergo evaluations from clinical, circadian rhythm, and neurocognitive perspectives at baseline, 6-month, and 12-month follow-ups, involving questionnaires, actigraphy, and computed neurocognitive tests. We will examine both cross-sectional and longitudinal associations between participants’ circadian rhythm patterns and neurocognitive functioning. Statistical analyses will employ Spearman correlation and mixed regression models. Discussion: We anticipate that circadian rhythms may serve as predictors of neurocognitive functioning changes. The findings of this study could offer supplementary insights into BD pathophysiology, potential treatment targets, and prediction. Trial Registration: This study has been registered with the Chinese Clinical Trial Registry under the registration code ChiCTR2200064922 on 21st October 2022.

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Sleep quality and neuropsychological functioning in bipolar I disorder

Cited by 7 publications

References 57 publications

Relative associations of behavioral and physiological risks for cardiometabolic disease with cognition in bipolar disorder during mid and later-life: findings from the UK biobank

Relative associations of behavioral and physiological risks for cardiometabolic disease with cognition in bipolar disorder during mid and later-life: findings from the UK biobank

Relative Associations of Behavioural and Physiological Risks for Cardiometabolic Disease with Cognition in Bipolar Disorder: Findings from the UK Biobank

Can circadian rhythm predict changes in neurocognitive functioning in bipolar disorder: protocol of a 12-month longitudinal cohort study based on research domain criteria

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