Sleep quality and its correlates in patients with chronic kidney disease: a cross-sectional design

Abstract

Purpose: Since sympathovagal imbalance influences clinical phenomena, such as hypertension, diabetes mellitus, chronic kidney disease (CKD) and sleeping problems, there should be correlations between these conditions. We hypothesized that sleep quality would be correlated with estimated glomerular filtration rate (eGFR), blood pressure and the presence of diabetes. Methods: We included 303 CKD patients in this study. We employed the Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI) and Short Form 36 Quality of Life Health Survey Questions (SF-36) to screen sleeping disturbances, depression and quality of life, respectively. A chart review was performed for the patients' demographics, diagnoses and certain laboratory parameters-including blood glucose, hemoglobin, albumin, calcium, phosphate, parathyroid hormone and eGFR. Multivariate logistic regression models were employed to estimate odds ratios with 95% confidence intervals. Results: We included 303 patients in this cross-sectional study. A total of 101 patients were on dialysis. In the univariate models, gender, calcium and mental component summary scores (MCS) reached a significant level of 0.1, and those covariates were included in the multivariate analysis. The reduced models included gender and MCS categories. Female gender increases the risk for poor sleep quality. In our report, evidence suggests MCS domain scores are inversely related to the risk for impaired sleep. Conclusion: Our results indicated a high burden of sleep disturbances in kidney patients. In addition, female gender and having low MCS scores may influence sleep quality in kidney patients.

Associations of common chronic non-communicable diseases and medical conditions with sleep-related problems in a population-based health examination study

“…However, some earlier studies have shown that sleep problems had increased the risk of CVDs, hypertension, diabetes, and obesity, all of which were implicated in the etiology of chronic kidney diseases [43]. More recent studies have indicated sleep problems also among kidney patients [44], [45]. In line with the existing evidence, the present study too showed that all of the sleep problems increased the odds of renal failure.…”

Subjective sleep quality, blood pressure, and hypertension: a meta‐analysis

“…Upon exclusion of studies that included patients with diabetes mellitus, urinary tract infections, and chronic kidney diseases, the association between poor sleep quality and SBP (mean difference, 3.99; 95% CI, −3.88 to 11.86 [ I 2 = 98%]) or DBP (mean difference, 1.23; 95% CI, −2.28 to 4.74 [ I 2 = 95%]) remained statistically insignificant and highly heterogeneous.…”

The effects of cool dialysate on quality of sleep among patients undergoing hemodialysis: A randomized clinical trial

“…In a study by Elder et al .,[ 5 ] the lower scores on sleep quality were associated with a variety of cardiovascular problems, mental disorders, depression, itching, and pain. Considering that a cold dialysis solution can be effective in improving cardiovascular problems, depression, pain, and itching,[ 9 ] sleep disturbances may be indirectly improved.…”

“…Recent studies have shown that insomnia, sleep deprivation, and general sleep disorders are associated with the exacerbation of cardiovascular diseases, decreased quality of life, and increased mortality in hemodialysis patients. [ 9 ]…”