Sleep Quality and 1-Year Incident Cognitive Impairment in Community-Dwelling Older Adults

Potvin, Olivier; Lorrain, Dominique; Forget, Hélène; Dubé, Micheline; Grenier, Sébastien; Préville, Michel; Hudon, Carol

doi:10.5665/sleep.1732

Cited by 220 publications

(208 citation statements)

References 71 publications

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“…Other studies have identified sex differences in sleep duration and neurocognitive function such that females with long sleep (> 9 h per night) had cognitive impairment at one year of follow-up; while short sleep (< 5 h per night) predicted cognitive decline in males. 36 Our findings suggest that sleep duration may differentially affect neurocognitive function in men and women.…”

Section: Discussionmentioning

confidence: 67%

Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos

Ramos

Tarraf

Daviglus

et al. 2016

Sleep

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Study Objectives: To evaluate the association between sleep duration and neurocognitive function in a representative sample of middle-aged to older Hispanic/Latino adults in the US. We tested the hypothesis that sleep duration has a nonlinear, inverted U-shaped association with neurocognitive function. Methods: We performed a cross-sectional analysis from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants ages 45-74 years (n = 8,676). HCHS/SOL is a community-based cohort from four US urban areas sampled using a probability design from 2008-2011. Self-reported sleep duration was calculated as a weighted average of the difference between habitual wake and bedtimes assessed by separate questions for weekdays and weekends. Neurocognitive function was measured with standardized scores for Word (Phonemic) Fluency (WF), Brief-Spanish English Verbal learning test (B-SEVLT), and Digit Symbol Substitution (DSS) tests. Results: The mean age was 56.5 years; 55% were women; and 40.4% had less than high school education. Average sleep duration was 7.8 ± 1.7 hours. There was an inverted U-shaped association with sleep duration and WF, B-SEVLT sum, and the DSS, with no association with B-SEVLT delayed-recall. Participants with intermediate sleep duration had the best neurocognitive function, while long sleepers had worse neurocognitive function adjusting for demographic, behavioral, and medical factors, daytime sleepiness, and use of sleep medications. Conclusions: Sleep duration had curvilinear inverted U-shaped associations with neurocognitive function, with worse scores among participants with longer sleep duration. These findings may provide a framework to further examine sleep duration in the prevention and treatment of neurocognitive disorders.

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Section: Discussionmentioning

confidence: 67%

Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos

Ramos

Tarraf

Daviglus

et al. 2016

Sleep

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“…As a sensitivity analysis, we also evaluated the relation between sleep hours and memory performance on the MMSE, given that verbal 3-word recall on the MMSE has been reported as an acceptable estimate of episodic memory in epidemiologic studies. 24 Among participants able to register 3 initial words, impaired verbal recall was defined by a score of 0 or 1 obtained on the subsequent 3-word recall task of the MMSE. 24 Additionally, we evaluated the interactions between sleep hours and the covariates.…”

Section: Discussionmentioning

confidence: 99%

“…24 Among participants able to register 3 initial words, impaired verbal recall was defined by a score of 0 or 1 obtained on the subsequent 3-word recall task of the MMSE. 24 Additionally, we evaluated the interactions between sleep hours and the covariates. All analyses were performed using SAS software version 9.3 (SAS Institute Inc, Cary, NC).…”

Section: Discussionmentioning

confidence: 99%

“…6 A cross-sectional analysis of the Osteoporotic Fractures in Men Study (MrOS) also demonstrated an association between long sleep (≥ 8 h) by actigraphy and worse global cognitive scores. 27 Population-based studies have reported associations between long sleep duration and worse cognitive performance by measures of global cognition (MMSE), 24,28 as well as verbal fluency, delayed recall, 29 and psychomotor speed. 30 Most studies on sleep hours and cognitive function have examined homogenous populations, with a paucity of data from racially/ethnically diverse communities.…”

Section: Discussionmentioning

confidence: 99%

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Association between Sleep Duration and the Mini-Mental Score: The Northern Manhattan Study

Ramos

Dong

Elkind

et al. 2013

Journal of Clinical Sleep Medicine

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“…In essence, sleep impairment may represent a risk factor for the disease. In support of this hypothesis, studies show that both self-reported sleep problems [25][26][27] and rest fragmentation at night [28] increase the risk of developing dementia, including dementia caused by AD.…”

Section: Associations Between Sleep Disruption and Admentioning

confidence: 91%

Is Sleep Disruption a Risk Factor for Alzheimer’s Disease?

Macedo

Balouch

Tabet

2017

JAD

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Sleep disturbances are routinely encountered in Alzheimer's disease (AD) and affect about 25-40% of patients in the mild-to-moderate stages of the disease. In many, sleep pathology may represent a symptom of the underlying neurodegeneration. However, a history of sleep disruption occurring years prior to onset of cognitive symptoms could represent a potential risk factor for AD. The aim of the present narrative review was to evaluate current evidence linking sleep disturbances with AD development and to understand the mechanisms that may contribute to this.Although the mechanisms by which poor sleep may contribute to AD genesis is not fully understood, emerging evidence linking disturbances in the sleep wake cycle with Aβ deposition is shedding light on the relationship between sleep pathology and the subsequent development of AD. Aβ burden appears to be enhanced by sleep-wake cycle disruptions and is suspected as being an important mechanism by which sleep disruptions contribute in AD development. Other mechanisms triggered by sleep disruption may also be involved in AD development, such as brain hypoxia, oxidative stress, circadian activity rhythms disturbances, overexpression of orexins and blood brain barrier impairment. Further understanding of the link between sleep disturbances and future development of AD is still needed before sleep disturbances are clearly marked as a preventable risk factor for AD. In these circumstances, early lifestyle interventions to help increase the quantity and quality of sleep may have a favorable outcome on decreasing the incidence of AD and this needs to be investigated further.

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Sleep Quality and 1-Year Incident Cognitive Impairment in Community-Dwelling Older Adults

Abstract: Sleep quality in older adults should receive particular attention by clinicians because poor sleep quality can be an early sign of cognitive decline.

Cited by 220 publications

References 71 publications

Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos

Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos

Association between Sleep Duration and the Mini-Mental Score: The Northern Manhattan Study

Is Sleep Disruption a Risk Factor for Alzheimer’s Disease?

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