Sleep problems in Parkinson’s disease: a community-based study in Norway

Svensson, Elisabeth; Beiske, Antonie Giæver; Loge, Jon Håvard; Beiske, Kornelia Katalin; Sivertsen, Børge

doi:10.1186/1471-2377-12-71

Cited by 30 publications

(27 citation statements)

References 38 publications

(48 reference statements)

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“…We found that the poor sleepers had significant higher UPDRS scores. Our finding contrasted with a community‐based study in Norway (Svensson et al., 2012), but is in agreement with a case–control study conducted in India (Kumar et al., 2002). In addition, poor sleep was positively correlated with the dosage of levodopa and hypnotics in our and two other studies (Antczak et al., 2013; Verbaan, van Rooden, Visser, Marinus, & van Hilten, 2008).…”

Section: Discussionsupporting

confidence: 92%

“…Some authors have argued that EDS could be an integral part of PD rather than the result of poor nighttime sleep quality (Goldman et al., 2013). In addition, whether clinical characteristics such as disease severity, Unified Parkinson's Disease Rating Scale (UPDRS) score, and the prescription of dopaminergic medication are risk factors for sleep disturbance remains controversial (Hoglund, Broman, Palhagen, Fredrikson, & Hagell, 2015; Kumar, Bhatia, & Behari, 2002; Ondo et al., 2001; Pandey, Bajaj, Wadhwa, & Anand, 2016; Svensson, Beiske, Loge, Beiske, & Sivertsen, 2012; Tholfsen, Larsen, Schulz, Tysnes, & Gjerstad, 2015). …”

Section: Introductionmentioning

confidence: 99%

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Sleep disturbances in Taiwanese patients with Parkinson's disease

Lin

Chen

et al. 2017

Brain and Behavior

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IntroductionSleep disturbance is a common nonmotor symptom of Parkinson's disease (PD) and strongly affects patients’ quality of life. The relationship between excessive daytime sleepiness (EDS) and nighttime problems remains uncertain. Arguments persist regarding the risk factors for sleep disturbance among patients with PD. Furthermore, the prevalence of EDS appears to be lower in Asian countries. Herein, we conducted the study to describe the characteristics of sleep problems in a sample of Taiwanese PD patients and delineate the difference with reported sleep disturbances in Caucasian PD patients from the literature.MethodsPatients with PD were recruited from the outpatient clinic of a tertiary medical center and were evaluated using standardized assessment protocols, including the Parkinson's Disease Sleep Scale (PDSS), the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and 39‐Item Parkinson's Disease Questionnaire (PDQ‐39).ResultsA total of 225 patients with PD were recruited. The mean age of patients with PD was 65.7 years old and the mean disease duration was 8.18 years. Among the patients, 53.8% were defined as poor sleepers (PSQI > 5) and 26.3% had EDS. Seventy‐one percent of the poor sleepers used hypnotic medications. The poor sleepers were worse in the scores of Unified Parkinson's Disease Rating Scale (UPDRS), PDSS, and the PDQ‐39, and received higher levodopa daily dosage. A PDSS score of <126 indicate that a patient with PD was a poor sleeper. EDS was positively correlated with advanced Hoehn and Yahr stages and use of dopamine agonists but not with levodopa daily dosage and levodopa equivalent daily dosage.ConclusionsTaiwanese patients with PD had a lower prevalence of EDS compared with the literatures reported in Caucasian patients. We identify and suggest that PDSS total score, rather than subcategory items, should be used to predict poor sleep among patients with PD.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Sleep disturbances in Taiwanese patients with Parkinson's disease

Lin

Chen

et al. 2017

Brain and Behavior

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“…Some specific sleep scales for PD populations find more sleep complaints in PD patients with RLS than in PD patients without RLS. The relationship between Parkinson's Disease Sleep Scale (PDSS) and RLS remained still significant when item on nocturnal restlessness was removed from the analysis [10]. In the current study, there appeared more daytime sleepiness (SEDS >15), other sleep complaints and low quality of life (WHO5 <50: 39.9 vs. 54.3%, adjusted OR 1.58, 95% CI 1.03-2.44) in the PD-RLS group.…”

Section: Discussionmentioning

confidence: 99%

“…Non-motor symptoms, including sleep disorders, for example, RLS, are important features of the disease. The prevalence of RLS in PD cohorts has varied from 5.5 to 27% in European studies [7,8,9,10,11]. The prevalence of RLS in drug-naïve patients with PD has varied from 5.5 to 16.5% [7,12,13].…”

Section: Introductionmentioning

confidence: 99%

Parkinson's Disease and Restless Legs Syndrome

Ylikoski¹,

Martikainen²,

Partinen³

2015

Eur Neurol

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Aims: Various sleep-related complications are common in Parkinson's disease (PD). The prevalence of restless legs syndrome (RLS) and its association with other symptoms were studied. Methods: Altogether, 1,447 Parkinson patients, aged 43-89, participated in a questionnaire study. Results: The response rate was 59.0% and of these, 68% returned fully answered questionnaires (n = 577). RLS occurred in 20.3% of the PD subjects. In patients with RLS, the symptoms occurred in 81.9% at least once weekly. The degree of severity was moderate in 42.7%, severe in 23.9% and very severe in 15.4%. Daytime sleepiness, fatigue, chronic insomnia, sleep maintenance insomnia, intense dreaming, and low quality of life were more common in patients with RLS than in patients without RLS. The occurrence of early onset RLS (onset ≤ age of 45 years) was 4.2%. The occurrences of late onset (>45 years) drug naïve RLS and late onset RLS (with dopaminergic medication) were 5.4 and 10.4%, respectively. Conclusion: In patients with PD, the early onset of RLS resembles idiopathic RLS with typical gender distribution and familial trait. Late onset of RLS is more common than idiopathic RLS.

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“…Furthermore, previous studies on PD patients have reported the prevalence of insomnia symptoms [6,7] or insomnia according to one compound question [8,9] or subthreshold insomnia [10]. Lastly insomnia is known to overlap with multiple medical problems and comorbid sleep disorders.…”

Section: Introductionmentioning

confidence: 98%

Parkinson’s disease and insomnia

Ylikoski¹,

Martikainen²,

Siemiński

et al. 2015

Neurol Sci

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There is a broad spectrum of sleep disturbances observed in Parkinson's disease (PD). The prevalence of symptoms of insomnia and chronic inability to sleep and their association with other sleep disorders were studied. Altogether 1447 randomly selected Parkinson patients, aged 43-89 years, participated in a questionnaire study. A structured questionnaire with 207 items was based on the Basic Nordic Sleep questionnaire. Questions on demographics, PD, REM Sleep Behavior Disorder, and other issues were included. The response rate was 59 % (N = 854), and of these 81 % returned fully answered questionnaire (N = 689). Prevalence of chronic inability to sleep was 36.9 % (95 % CI 33.3-40.5). Difficulty of initiating sleep was 18.0 % (95 % CI 15.1-20.9), disrupted sleep 81.54 % (78.5-84.4), awakenings during night 31.3 % (27.8-34.8), early morning awakenings 40.4 % (36.8-44.1) and non-restorative sleep 38.5 % (34.8-42.1). In the logistic regression models, poor quality of life and restless legs syndrome correlated significantly with chronic insomnia disorder. Disrupted sleep and early morning awakenings were the most common insomnia symptoms. PD patients do not seem to have difficulties in sleep initiation. Insomnia symptoms including disruptive sleep and non-restorative sleep are common in patients with Parkinson's disease. Inability to sleep is more common as comorbidity than a single sleep problem.

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Sleep problems in Parkinson’s disease: a community-based study in Norway

Cited by 30 publications

References 38 publications

Sleep disturbances in Taiwanese patients with Parkinson's disease

Sleep disturbances in Taiwanese patients with Parkinson's disease

Parkinson's Disease and Restless Legs Syndrome

Parkinson’s disease and insomnia

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