Sleep problems during and after paediatric brain tumours

Litsenburg, Raphaële R. L. van; Kamara, Dana; Irestorm, Elin; Partanen, Marita; Vries, Ralph de; Crabtree, Valerie McLaughlin; Daniel, Lauren C.

doi:10.1016/s2352-4642(22)00380-7

The Lancet Child & Adolescent Health

2023

DOI: 10.1016/s2352-4642(22)00380-7

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Sleep problems during and after paediatric brain tumours

Raphaële R. L. van Litsenburg¹,

Dana Kamara²,

Elin Irestorm³

et al.

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2024

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Cited by 2 publications

(1 citation statement)

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“…Sleep disturbances are common across the continuum of cancer survivorship ( 4 , 5 ), posing a threat to health and quality of life for long-term survivors. Sleep disturbances are linked to impairments in both mental and physical health ( 6 , 7 ) as well as earlier mortality ( 8 ) in the general population and in childhood cancer survivors ( 9-12 ).…”

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confidence: 99%

Mechanisms of sleep disturbances in long-term cancer survivors: a childhood cancer survivor study report

Daniel,

Wang,

Brinkman

et al. 2024

JNCI Cancer Spectrum

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Background Sleep problems following childhood cancer treatment may persist into adulthood, exacerbating cancer-related late effects and putting survivors at risk for poor physical and psychosocial functioning. This study examines sleep in long-term survivors and their siblings to identify risk factors and disease correlates. Methods Childhood cancer survivors (≥5 years from diagnosis; n = 12,340; 51.5% female; mean[SD] age = 39.4[9.6] years) and siblings (n = 2395; 57.1% female; age = 44.6[10.5] years) participating in the Childhood Cancer Survivor Study completed the Pittsburgh Sleep Quality Index (PSQI). Multivariable Poisson-error generalized estimating equation compared prevalence of binary sleep outcomes between survivors and siblings and evaluated cancer history and chronic health conditions (CHC) for associations with sleep outcomes, adjusting for age (at diagnosis and current), sex, race/ethnicity, and BMI. Results Survivors were more likely to report clinically-elevated composite PSQI scores (>5; 45.1% vs 40.0%, adjusted prevalence ratio [PR] 1.20, 95%CI 1.13-1.27), symptoms of insomnia (38.8% vs 32.0%, PR = 1.26, 95%CI 1.18-1.35), snoring (18.0% vs 17.4%, PR = 1.11, 95%CI 1.01-1.23), and sleep medication use (13.2% vs 11.5%, PR = 1.28, 95%CI 1.12-1.45) compared to siblings. Within cancer survivors, PSQI scores were similar across diagnoses. Anthracycline exposure (PR = 1.13, 95%CI 1.03-1.25), abdominal radiation (PR = 1.16 95%CI 1.04-1.29) and increasing CHC burden were associated with elevated PSQI scores (PRs 1.21-1.48). Conclusions Among survivors, sleep problems were more closely related to CHC than diagnosis or treatment history, though longitudinal research is needed to determine the direction of this association. Frequent sleep-promoting medication use suggests interest in managing sleep problems; behavioral sleep intervention is advised for long-term management.

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confidence: 99%

Mechanisms of sleep disturbances in long-term cancer survivors: a childhood cancer survivor study report

Daniel,

Wang,

Brinkman

et al. 2024

JNCI Cancer Spectrum

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Sleep problems and impact of obstructive hydrocephalus in newly diagnosed pediatric brain tumor patients

Hooft van Huijsduijnen,

Partanen,

Grootenhuis

et al. 2023

EJC Paediatric Oncology

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Sleep problems during and after paediatric brain tumours

Cited by 2 publications

References 75 publications

Mechanisms of sleep disturbances in long-term cancer survivors: a childhood cancer survivor study report

Mechanisms of sleep disturbances in long-term cancer survivors: a childhood cancer survivor study report

Sleep problems and impact of obstructive hydrocephalus in newly diagnosed pediatric brain tumor patients

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