Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries

Smıth, Lee; Jacob, Louis; Carmichael, Christina; Sánchez, Guillermo Felipe López; Oh, Hans; Butler, Laurie; Barnett, Yvonne; Pizzol, Damiano; Tully, Mark; Soysal, Pınar; Veronese, Nicola; Koyanagi, Ai

doi:10.1016/j.exger.2021.111513

Cited by 11 publications

(11 citation statements)

References 35 publications

(36 reference statements)

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“…This can cause over excitability in the brain immune cells, such as microglia, causing inflammation, cell death, and neurodegeneration. Over time this can eventually cause neuronal death, changes in brain structure and function leading to cognitive decline (Figure 1a) [10][11][12]. This will be discussed further in the next section.…”

Section: Figurementioning

confidence: 98%

“…Two key physiological features of OSAHS, sleep fragmentation and intermittent hypoxia, are proposed to cause cognitive dysfunction [30,49]. These features are proposed to promote oxidative stress, reduce slow wave sleep (SWS) duration, generate intrathoracic pressure swings, and reduce rapid eye movement sleep (REM) [11,18,49,60]. The proposed pathways by which each of these physiological changes leads to cognitive impairment will be discussed in Figure . 1a and 1b respectively.…”

Section: Figurementioning

confidence: 99%

“…Reduction in slow wave and rapid eye movement sleep, and intrathoracic pressure swings, has been proposed to reduce the activity of the glymphatic system by reducing the fluid diffusivity across the brain [11,18,36,37,38,60]. Reduction in brain clearance promote an increase in accumulated metabolites in the brain (such as amyloid beta and tau proteins) [6,56].…”

Section: Figure 1amentioning

confidence: 99%

“…In the long-term this inflammatory process leads to neuronal death causing structural changes in the brain [37,58]. Deficits in synaptic plasticity and neuronal death leads to cognitive impairment [11,29,31,35].…”

Section: Figure 1amentioning

confidence: 99%

“…Search term PubMed ("Mild cognitive impairment" OR "cognitive decline" OR "cognitive dysfunction" OR "mild cognitive deficit" OR "Alzheimer disease" OR AD OR amyloid OR "MCI" OR "amnestic mild cognitive impairment" OR "degenerative disease" OR "amyloid precursor protein A total of 45 studies were found. Of the 45, 15 studies discussed the hypothesised glymphatic system in relation to sleep [11,12,[23][24][25][26][27][28][29][30][31][32][33][34][35], 5 studies assessed the impact of PAP on brain fluid diffusivity in patients with OSAHS [36][37][38][39][40], 4 studies assessed the influence of PAP treatment on the level of AD biomarkers [29,31,41,42], 11 studies measured the impact of PAP treatment on cognitive function in OSAHS [1,4,14,[43][44][45][46][47][48][49][50] and 10 studies measured the impact of PAP treatment on cognitive function in OSAHS and aMCI/AD [7,8,17,20,21,[51][52][53][54]…”

Section: Databasementioning

confidence: 99%

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Positive airway pressure improves amnestic mild cognitive impairment in patients diagnosed with obstructive sleep apnoea hypopnoea syndrome. A review of the evidence

Parsons

2024

IJCCR

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There is growing clinical evidence showing the impact of sleep disturbance on the development of Alzheimer’s disease (AD). It has been proposed that intermittent hypoxia and sleep fragmentation, which are hallmarks of obstructive sleep apnoea hypopnoea syndrome (OSAHS), are physiological changes that may contribute to cognitive impairment. Sleep fragmentation reduces slow-wave sleep duration affecting the efficiency of the brain clearance system, allowing metabolic proteins to accumulate. These proteins contribute to neurodegeneration, brain atrophy, and cognitive impairment. Improvements in fluid diffusion which leads to the reduction in the accumulation of metabolic proteins, have been observed after positive airway pressure (PAP) treatment. Treating OSAHS may be effective in reducing the risk of neuronal damage and improve cognitive function. This review outlines the current knowledge associating OSAHS and AD and discusses the effect of PAP treatment on cognitive function, AD biomarkers, and the brain clearance system.

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Section: Figurementioning

confidence: 98%

Section: Figurementioning

confidence: 99%

Section: Figure 1amentioning

confidence: 99%

Section: Figure 1amentioning

confidence: 99%

Section: Databasementioning

confidence: 99%

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Positive airway pressure improves amnestic mild cognitive impairment in patients diagnosed with obstructive sleep apnoea hypopnoea syndrome. A review of the evidence

Parsons

2024

IJCCR

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Pain and mild cognitive impairment among adults aged 50 years and above residing in low- and middle-income countries

et al. 2023

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Background Previous studies on the association between pain and cognitive decline or impairment have yielded mixed results, while studies from low- and middle-income countries (LMICs) or specifically on mild cognitive impairment (MCI) are scarce. Thus, we investigated the association between pain and MCI in LMICs and quantified the extent to which perceived stress, sleep/energy problems, and mobility limitations explain the pain/MCI relationship. Methods Data analysis of cross-sectional data from six LMICs from the Study on Global Ageing and Adult Health (SAGE) were performed. MCI was based on the National Institute on Aging-Alzheimer's Association criteria. "Overall in the last 30 days, how much of bodily aches or pain did you have?” was the question utilized to assess pain. Associations were examined by multivariable logistic regression analysis and meta-analysis. Results Data on 32,715 individuals aged 50 years and over were analysed [mean (SD) age 62.1 (15.6) years; 51.7% females]. In the overall sample, compared to no pain, mild, moderate, and severe/extreme pain were dose-dependently associated with 1.36 (95% CI = 1.18–1.55), 2.15 (95% CI = 1.77–2.62), and 3.01 (95% CI = 2.36–3.85) times higher odds for MCI, respectively. Mediation analysis showed that perceived stress, sleep/energy problems, and mobility limitations explained 10.4%, 30.6%, and 51.5% of the association between severe/extreme pain and MCI. Conclusions Among middle-aged to older adults from six LMICs, pain was associated with MCI dose-dependently, and sleep problems and mobility limitations were identified as potential mediators. These findings raise the possibility of pain as a modifiable risk factor for developing MCI.

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Study on Sleeping Problems and Mental Health and their Association among Older Adults in India

Rathod,

Bramhankar,

Jungari

2024

Glob Soc Welf

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Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries

Cited by 11 publications

References 35 publications

Positive airway pressure improves amnestic mild cognitive impairment in patients diagnosed with obstructive sleep apnoea hypopnoea syndrome. A review of the evidence

Positive airway pressure improves amnestic mild cognitive impairment in patients diagnosed with obstructive sleep apnoea hypopnoea syndrome. A review of the evidence

Pain and mild cognitive impairment among adults aged 50 years and above residing in low- and middle-income countries

Study on Sleeping Problems and Mental Health and their Association among Older Adults in India

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