Sleep Positional Therapy for Nocturnal Gastroesophageal Reflux: A Double-Blind, Randomized, Sham-Controlled Trial

Schuitenmaker, Jeroen M.; Kuipers, Thijs; Nijhuis, Renske A B Oude; Schijven, M.P.; Smout, A. J. P. M.; Fockens, Paul; Bredenoord, Albert J.

doi:10.1016/j.cgh.2022.02.058

Cited by 14 publications

(22 citation statements)

References 24 publications

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“…This effect was maintained throughout the whole treatment period. These results are consistent with a study previously performed by our group 6 . In this double‐blind, randomized, sham‐controlled trial in 100 patients with nocturnal symptoms of gastroesophageal reflux, we demonstrated that treatment with this device led to 1 an increase of sleeping in the left lateral decubitus position and 2 effectively reduced nocturnal reflux symptoms compared to sham treatment.…”

Section: Discussionsupporting

confidence: 92%

“…24,25 We have previously demonstrated that sleep positional therapy effectively alleviated nocturnal reflux symptoms. 6 The results of this study indicates that sleep positional therapy also improves pH-impedance parameters, adding to the evidence that this novel therapy is a valuable addition to the GERD treatment regime.…”

Section: Discussionsupporting

confidence: 51%

“…Indeed, the left lateral decubitus position is associated with significantly shorter nocturnal esophageal acid exposure time and faster esophageal acid clearance compared with the supine and right lateral decubitus positions 5 . The results of a recent study by our group suggest that nocturnal reflux may be reduced with an electronic sleep positional wearable device, as it promotes sleeping in the left lateral decubitus position and effectively alleviates nocturnal reflux symptoms 6 . This small wearable device, placed with an adhesive sticker on the sternum, gently vibrates when the body is in the right lateral decubitus position.…”

Section: Introductionmentioning

confidence: 87%

“…5 The results of a recent study by our group suggest that nocturnal reflux may be reduced with an electronic sleep positional wearable device, as it promotes sleeping in the left lateral decubitus position and effectively alleviates nocturnal reflux symptoms. 6 This small wearable device, placed with an adhesive sticker on the sternum, gently vibrates when the body is in the right lateral decubitus position. The vibrating signal is effectively in nudging to change the sleep position, preferably with the intention of stimulating the subject to roll over to the left lateral decubitus position.…”

Section: Introductionmentioning

confidence: 99%

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The effect of sleep positional therapy on nocturnal gastroesophageal reflux measured by esophageal pH‐impedance monitoring

Schuitenmaker

Kuipers

Schijven

et al. 2023

Neurogastroenterology Motil

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Background & Aims The aim of the study was to evaluate the effect of an electronic positional therapy wearable device on nocturnal gastroesophageal reflux measured by pH‐impedance reflux monitoring. Methods We performed a single‐center, prospective, interventional study in 30 patients with nocturnal reflux symptoms and a nocturnal esophageal acid exposure time (AET) ≥1.5% measured off acid‐suppressive medication by ambulatory pH‐impedance reflux monitoring. Patients were treated with an electronic positional therapy wearable device for 2 weeks. The device vibrates in the right lateral decubitus position so it conditions patients to avoid that sleep position. After 2 weeks treatment, the pH‐impedance study was repeated. Primary outcome was the change in nocturnal AET. Secondary outcomes include change in number of reflux episodes and reflux symptoms. Results Complete data were available for 27 patients (13 females, mean age 49.8 years). The median nocturnal AET decreased from 6.0% (IQR, 2.3–15.3) to 3.1% (0.1–10.8) after 2 weeks of treatment (p = 0.079). The number of reflux episodes was significantly reduced after 2 weeks of treatment (baseline: 8.0 (3.0–12.3) vs. end: 3.0 (1.0–8.0); p = 0.041). Treatment led to a statistically significant decrease in time spent in right lateral decubitus position (baseline: mean 36.9% ± 15.2% vs. end: 2.7% ± 8.2%; p = <0.001) and an increase in the left lateral decubitus position (baseline 29.2% ± 14.8% vs. end: 63.3% ± 21.9%; p = <0.001). Symptom improvement was reported by 70.4% of the patients. Conclusions Sleep positional therapy using an electronic wearable device promotes sleeping in the left lateral decubitus position and improves reflux parameters measured by pH‐impedance reflux monitoring.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of sleep positional therapy on nocturnal gastroesophageal reflux measured by esophageal pH‐impedance monitoring

Schuitenmaker

Kuipers

Schijven

et al. 2023

Neurogastroenterology Motil

Self Cite

View full text Add to dashboard Cite

show abstract

“…Elhence and Ghoshal point out that there might be little benefit in promoting the left lateral decubitus sleeping position because the spontaneous position change during sleep is largely performed subconsciously. However, our recent double-blind, randomized, sham-controlled trial in patients with nocturnal symptoms of gastroesophageal reflux shows that the sleep position can be effectively changed (3). We investigated a novel electronic sleep positional therapy wearable device, programmed to produce a vibration when in the right lateral decubitus position.…”

mentioning

confidence: 99%