Sleep patterns over 15-day period in rats with spinal cord injury

Esteves, A M; Mello, Marco Túlio de; Squarcini, Camila Fabiana Rossi; Lancellotti, Carmen Lúcia Penteado; Comparoni, Aniella; Tufik, Sérgio

doi:10.1038/sj.sc.3101971

Cited by 16 publications

(10 citation statements)

References 17 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Somatosensory deafferentation could also have a role in the complex spectrum of sleep disturbances observed after spinal cord injury. [37][38][39][40][41][42] In any case, our data are limited to the first few hours after spinal cord injury in a rat animal model with urethane anesthesia, and further investigation should be conducted in patients.…”

Section: Discussionmentioning

confidence: 99%

Spinal cord injury immediately decreases anesthetic requirements in rats

et al. 2011

View full text Add to dashboard Cite

Study design: Pharmacologically blocking the spinal cord produces sedative effects and reduces anesthesia requirements in patients and animals. Whether spinal cord injury also reduces anesthesia requirements remains unclear. Methods: We retrospectively analyzed data from urethane-anesthetized rats 15 to assess anesthesia requirements immediately after complete thoracic transection of the spinal cord. The depth of anesthesia was monitored up to 12 h after spinal transection by the reflexes to noxious stimuli and by electrophysiological recordings from the infragranular layers of the primary somatosensory cortex. Whenever animals displayed electrophysiological and/or behavioral signs of activation, we delivered an additional dose of anesthesia. Anesthetic requirements in animals receiving spinal transection (n ¼ 11) were compared with control animals receiving 'sham' lesion (n ¼ 9). Results: The cumulative dose necessary to maintain a stable level of anesthesia was significantly lower in transected animals compared with control animals. By about 7 h after spinal cord injury, on average the cumulative dose of urethane was only 1.13 ± 0.14 of the original dose, compared with 1.64 ± 0.19 of the original dose in control animals. Conclusions: Spinal transection immediately decreased anesthetic requirements in rats. To establish whether these results are relevant for patients with spinal cord injury will require further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Spinal cord injury immediately decreases anesthetic requirements in rats

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Such an analysis would be extremely important because ferritin is an endothelial reticulum protein responsible for storing iron, and there is a relationship between serum ferritin levels and the amount of iron stored. 17 In previous studies, 7,8 we found increased limb movements during sleep in rats from 4 days after SCI onward. Because the present investigation demonstrated reduced levels of plasma iron in rats 1, 3, 7 and 15 days after SCI, our findings suggest a temporal association between increased limb movements induced by SCI and reduced levels of plasma iron.…”

Section: Discussionmentioning

confidence: 61%

“…In their study, the animals began to present leg movements during sleep at 4 days after SCI. In 2007, Esteves et al 8 analyzed sleep patterns in SCI animals. In addition to experiencing reduced sleep efficiency and an increased number of arousals, the animals presented limb movements that began at 4 days after lesion and remained until the end of the experiment, thus constituting a PLM animal model with SCI.…”

Section: Introductionmentioning

confidence: 99%

Plasma iron levels appraised 15 days after spinal cord injury in a limb movement animal model

et al. 2010

Self Cite

View full text Add to dashboard Cite

“…Numerous studies in animals have documented dramatic changes in rat muscle myosin heavy-chain (MHC) isoforms after SCI, with a complete reduction in neuromuscular activity leading to atrophy of the skeletal muscle [8,9,10]. Additionally, Esteves et al [11,12] demonstrated that rats exhibited changes in their sleep patterns after SCI, including increased arousals and limb movements during sleep.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Muscle Fibers in Rats with Limb Movements during Sleep after Spinal Cord Injury

et al. 2012

View full text Add to dashboard Cite

Background/Aims: Previous studies have demonstrated that spinal cord injury (SCI) results in changes in sleep patterns through increased arousals and limb movements during sleep. Dramatic changes in muscle myosin heavy-chain isoforms have also been reported. The aim of this study was to investigate the characteristics of muscle fibers after SCI in rats with limb movements during sleep. Methods: Forty male Wistar rats were divided into four groups: SHAM, SCI 3, 7 and 15 days. Animals were subjected to electrode insertion surgery, 24-hour baseline sleep recording, SCI, and subsequent sleep recording for 3, 7, or 15 consecutive days. In addition, the gastrocnemius muscle and spinal cord were collected for histopathological/histochemical analyses. Results: Our results indicate a rapid and progressive decrease in the cross-sectional area of type I fibers in the gastrocnemius muscle (35.76–24.74 µm²) after SCI. Additionally, we found SCI-induced changes in sleep patterns. Following SCI, we also observed limb movements in sleeping rats, as well as significant negative moderate correlations between type I fibers and limb movement. Conclusion: Our study strengthened the hypothesis by correlation between changes in types of muscle fiber (decline in type I fibers) and an increase in limb movements during sleep after SCI.

show abstract

Sleep patterns over 15-day period in rats with spinal cord injury

Cited by 16 publications

References 17 publications

Spinal cord injury immediately decreases anesthetic requirements in rats

Spinal cord injury immediately decreases anesthetic requirements in rats

Plasma iron levels appraised 15 days after spinal cord injury in a limb movement animal model

Characteristics of Muscle Fibers in Rats with Limb Movements during Sleep after Spinal Cord Injury

Contact Info

Product

Resources

About