Abstract:Impaired cholinergic neurotransmission can affect memory formation and influence
sleep-wake cycles (SWC). In the present study, we describe the SWC in mice with
a deficient vesicular acetylcholine transporter (VAChT) system, previously
characterized as presenting reduced acetylcholine release and cognitive and
behavioral dysfunctions. Continuous, chronic ECoG and EMG recordings were used
to evaluate the SWC pattern during light and dark phases in VAChT knockdown
heterozygous (VAChT-KDHET, n=7) and wild-type (W… Show more
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