Sleep parameters associated with long-term outcome following subthalamic deep brain stimulation in Parkinson's disease

Torun, Nurhan; Şenel, Gülçin Benbir; Gündüz, Ayşegül; Karadeniz, Derya; Kızıltan, Güneş; Ertan, Sibel; Aydın, Sabri; Yağcı, Selin; Apaydın, Hülya

doi:10.1016/j.neurol.2019.07.020

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…showed no improvement in the total PSQI score, 3 months after STN-DBS. However, the subscales of the PSQI revealed that the subjective sleep latency was significantly decreased, and sleep duration was significantly increased [ 52 ].…”

Section: Impact Of Dbs On the Overall Sleepmentioning

confidence: 99%

“…reported a deterioration of objective sleep parameters at 6 months after STN-DBS, characterized by a decrease in total sleep time and N2 sleep and an increase in arousals, in spite of an improvement of subjective sleep parameters [ 40 ]. Furthermore, it is generally considered that REM sleep features are not affected by STN-DBS, although a reduction in REM sleep latency with STN-DBS ON was reported in two studies [ 31 , 52 ].…”

Section: Impact Of Dbs On the Overall Sleepmentioning

confidence: 99%

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Effects of Deep Brain Stimulation on Sleep-Wake Disturbances in Patients with Parkinson's Disease: A Narrative Review

Jung

Kim

Paek

et al. 2021

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: Sleep-wake disturbances (SWD) are one of the most common non-motor symptoms in Parkinson's disease (PD) and can appear in the early stage even before the onset of motor symptoms. Deep brain stimulation (DBS) is an established treatment for the motor symptoms in patients with advanced PD. However, the effect of DBS on SWD and its specific mechanisms are not widely understood and remain controversial. In addition to the circuit-mediated direct effect, DBS may improve SWD by an indirect effect such as the resolution of nocturnal motor complications and a reduction of dopaminergic medication. Here, the authors review the recent literatures regarding the impact of DBS on SWD in patients with PD. Furthermore, the selection of the DBS targets and the specific effects of applying DBS to each target on SWD in PD are also discussed.

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Section: Impact Of Dbs On the Overall Sleepmentioning

confidence: 99%

Section: Impact Of Dbs On the Overall Sleepmentioning

confidence: 99%

Effects of Deep Brain Stimulation on Sleep-Wake Disturbances in Patients with Parkinson's Disease: A Narrative Review

Jung

Kim

Paek

et al. 2021

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“…Apart from enhancing motor functions, subthalamic nucleus deep brain stimulation (STN-DBS) showed promising efficacy in sleep quality improvements, for it was reported to enhance sleep quality, decrease sleep latency, extend sleep duration, and reduce daytime sleepiness. 5 – 7 Actigraphy and video-PSG also showed STN-DBS could promote deep sleep and overnight slow-wave activity. 6 , 8 …”

Section: Introductionmentioning

confidence: 99%

“…4 Apart from enhancing motor functions, subthalamic nucleus deep brain stimulation (STN-DBS) showed promising efficacy in sleep quality improvements, for it was reported to enhance sleep quality, decrease sleep latency, extend sleep duration, and reduce daytime sleepiness. [5][6][7] Actigraphy and video-PSG also showed STN-DBS could promote deep sleep and overnight slow-wave activity. 6,8 Three factors were commonly agreed to be related to sleep improvement under STN-DBS, including motor enhancements, anti-Parkinsonian drug reduction, and emotional symptom alleviations, all of which may be positively correlated with better sleep outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…6,8 Three factors were commonly agreed to be related to sleep improvement under STN-DBS, including motor enhancements, anti-Parkinsonian drug reduction, and emotional symptom alleviations, all of which may be positively correlated with better sleep outcomes. 5,7,[9][10][11] Previous studies have demonstrated that the positions and laterality of electrodes may yield different sleep outcomes. 6,[12][13][14] However, it remains contentious whether STN-DBS improves sleep qualities by directly affecting sleep circuits or indirectly alleviating other major symptoms like motor or emotions.…”

Section: Introductionmentioning

confidence: 99%

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Sleep outcomes and related factors in Parkinson’s disease after subthalamic deep brain electrode implantation: a retrospective cohort study

Yin

Chen

et al. 2023

Ther Adv Neurol Disord

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Background: Subthalamic nucleus deep brain stimulation (STN-DBS) improves sleep qualities in Parkinson’s disease (PD) patients; however, it remains elusive whether STN-DBS improves sleep by directly influencing the sleep circuit or alleviates other cardinal symptoms such as motor functions, other confounding factors including stimulation intensity may also involve. Studying the effect of microlesion effect (MLE) on sleep after STN-DBS electrode implantation may address this issue. Objective: To examine the influence of MLE on sleep quality and related factors in PD, as well as the effects of regional and lateral specific correlations with sleep outcomes after STN-DBS electrode implantation. Study Design: Case–control study; Level of evidence, 3. Data Sources and Methods: In 78 PD patients who underwent bilateral STN-DBS surgery in our center, we compared the sleep qualities, motor performances, anti-Parkinsonian drug dosage, and emotional conditions at preoperative baseline and postoperative 1-month follow-up. We determined the related factors of sleep outcomes and visualized the electrodes position, simulated the MLE-engendered volume of tissue lesioned (VTL), and investigated sleep-related sweet/sour spots and laterality in STN. Results: MLE improves sleep quality with Pittsburgh Sleep Quality Index (PSQI) by 13.36% and Parkinson’s Disease Sleep Scale-2 (PDSS-2) by 17.95%. Motor ( P = 0.014) and emotional ( P = 0.001) improvements were both positively correlated with sleep improvements. However, MLE in STN associative subregions, as an independent factor, may cause sleep deterioration ( r = 0.348, P = 0.002), and only the left STN showed significance ( r = 0.327, P = 0.004). Sweet spot analysis also indicated part of the left STN associative subregion is the sour spot indicative of sleep deterioration. Conclusion: The MLE of STN-DBS can overall improve sleep quality in PD patients, with a positive correlation between motor and emotional improvements. However, independent of all other factors, the MLE in the STN associative subregion, particularly the left side, may cause sleep deterioration.

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Exploring the network effects of deep brain stimulation for rapid eye movement sleep behavior disorder in Parkinson’s disease

Zhao,

Cheng,

Wang

et al. 2023

Acta Neurochir

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Sleep parameters associated with long-term outcome following subthalamic deep brain stimulation in Parkinson's disease

Cited by 5 publications

References 27 publications

Effects of Deep Brain Stimulation on Sleep-Wake Disturbances in Patients with Parkinson's Disease: A Narrative Review

Effects of Deep Brain Stimulation on Sleep-Wake Disturbances in Patients with Parkinson's Disease: A Narrative Review

Sleep outcomes and related factors in Parkinson’s disease after subthalamic deep brain electrode implantation: a retrospective cohort study

Exploring the network effects of deep brain stimulation for rapid eye movement sleep behavior disorder in Parkinson’s disease

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