Sleep outcomes associated with dry eye disease: a systematic review and meta-analysis

Au, Natalie H.; Mather, Rookaya; To, Alison; Malvankar-Mehta, Monali S.

doi:10.1016/j.jcjo.2018.03.013

Cited by 20 publications

(17 citation statements)

References 31 publications

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“…In people-based studies in Singapore (n=3,303), Lim et al found that daytime sleepiness, clinical insomnia, and short sleep periods (<5 hours) were associated with dry eyes, after correcting for socioeconomic and medical factors [ 21 ]. In a systematic review conducted by Au et al, the authors found that among 16,370 participants, DED patients had higher scores than control participants for both the PSQI and the Epworth Sleepiness Scale and they showed shorter duration of sleep, more sleep disturbances, and a higher prevalence and severity of sleep problems [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The Association Between Dry Eye and Sleep Quality Among the Adult Population of Saudi Arabia

Almutairi¹,

Algezlan²,

Bayamin³

et al. 2022

Cureus

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Background and objectiveDry eye disease (DED) is one of the most prevalent ocular diseases worldwide. DED symptoms can result from disturbances to the homeostasis of the middle tear film layer (aqueous layer), including inflammation, pain, and eye discomfort, which can have a negative impact on individuals' quality of life and daily activities. Sleep disorders are highly prevalent among patients with DED, and the incidence of sleep disturbances in DED patients has been reported to be as high as 40%. Decreased sleep quality can aggravate dry eye symptoms by increasing tear osmolarity and decreasing tear production. In this study, we aimed to investigate the association between DED and sleep quality in the adult population of Saudi Arabia. MethodsThis cross-sectional study was conducted among adult patients aged 18 years and above in Saudi Arabia in August 2021. A validated Arabic version of the Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and the Ocular Surface Disease Index (OSDI) questionnaire was employed to diagnose DED. Data collection and analysis were performed using the SPSS Statistics software (IBM, Armonk, NY). ResultsA total of 234 subjects were analyzed, and 59.8% of the participants were women. Our tool suggested that 71.4% of the included participants had severe DED, 15% had moderate DED, and 13.7% had mild DED. However, 40.6% of the participants reported that they had not been diagnosed with DED previously and 34.6% had no previous DED symptoms. The mean total PSQI score was 8.63 ±2.23, with the highest score recorded for component 2: sleep latency (1.73) and the lowest score recorded for component 4: habitual sleep efficiency (0.20). Poor sleep quality as assessed by PSQI showed a significant positive correlation with the severity of DED as assessed by OSDI. ConclusionThe significant positive correlation between poor sleep quality and DED indicated that patients with DED had a higher risk of poor sleep quality compared to healthy patients. Patients with DED should be educated about the steps and techniques to improve their sleep patterns.

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Section: Discussionmentioning

confidence: 99%

The Association Between Dry Eye and Sleep Quality Among the Adult Population of Saudi Arabia

Almutairi¹,

Algezlan²,

Bayamin³

et al. 2022

Cureus

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“…Specifically, respondents reported difficulty with reading, driving, work-related activities, outdoor activities, concentration and even sleep. Similarly, a recent systemic review and meta-analysis by Au et al (2019) reported that DED may be associated with poor sleep quality and sleep duration [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Sjögren’s Syndrome Associated Dry Eye: Impact on Daily Living and Adherence to Therapy

Michaelov,

McKenna,

Ibrahim

et al. 2022

JCM

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Sjögren’s syndrome-related dry eye disease (SS-DED) often involves more severe dry eye symptoms than people with non-SS dry eye disease (DED). This cross-sectional study employed an anonymous self-administered questionnaire to understand the experience of people living with SS-DED and to identify factors affecting adherence to DED self-care. Participants reported difficulty with visual tasks such as driving, and diminished enjoyment in daily activities due to DED symptoms. Almost 80% reported being worried about a reduced quality of life due to DED, and over 50% reported fear of blindness. The most common reasons for non-adherence were cost of therapy and forgetting to instill drops. Drop rationing to reduce cost of therapy was endorsed by 83% of respondents. Only 3% of respondents had private insurance for non-prescription agents required to treat DED. A quarter of respondents reported they would not disclose non-adherence to their eye care provider. Multiple regression analysis revealed age was a significant contributor to missing drops. This is the first study to report on the financial burden experienced by SS-DED patients in Canada. This paper identified strategies used by patients to reduce the cost of therapy and its impact on adherence to treatment. Patients may be reluctant to disclose challenges regarding adherence to DED therapy, as well as fears of worsening quality of life.

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“…The prevalence of sleep disorders in patients with DED has been reported from 15.3% to 64.3%. 27 Sleep quality may be affected by sleep latency, duration, and disturbances and result in changes in daytime functionality.…”

Section: Discussionmentioning

confidence: 99%

The effect of meibomian gland dysfunction treatment on sleep quality

et al. 2021

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Purpose: To assess the therapeutic efficacy of a combinational therapy, including conventional treatment and intense pulsed light (IPL) technique on sleep quality of patients with meibomian gland dysfunction (MGD). Methods: Fifty participants with a clinical diagnosis of MGD were enrolled in this study. Participants underwent three sessions of IPL therapy. There was a 2-week interval between IPL sessions 1 and 2 and 1 month between sessions 2 and 3. Treatment was supplemented with conventional home-based therapy (including lid hygiene, warm compress, eyelid massage, and lid margin scrub) for MGD. Dry eye symptomatology, tear film, and ocular surface parameters were evaluated at baseline (day 0) and days 15, 45, and 75. Sleep quality was assessed before and after the study using Pittsburgh Sleep Quality Index (PSQI). Results: PSQI components improved significantly at day 75 in comparison with the baseline (all P < 0.05). Ocular Surface Disease Index (OSDI) score, noninvasive Keratograph tear break-up time (NIKBUT), fluorescein tear break-up time (FTBUT), meibomian gland expressibility, meibum quality score, and tear osmolarity improved at follow-up visits ( P < 0.05). Younger patients showed more improvement in NIKBUT, sleep quality, and duration ( P = 0.024, P = 0.047, and P = 0.008). Sleep latency decreased with increased NIKBUT and FTBUT and decreased OSDI score ( P = 0.001, P = 0.005, and P = 0.041). Conclusions: The treatment of MGD is effective for improving sleep quality. Younger patients may preferentially benefit from the treatment.

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Sleep outcomes associated with dry eye disease: a systematic review and meta-analysis

Cited by 20 publications

References 31 publications

The Association Between Dry Eye and Sleep Quality Among the Adult Population of Saudi Arabia

The Association Between Dry Eye and Sleep Quality Among the Adult Population of Saudi Arabia

Sjögren’s Syndrome Associated Dry Eye: Impact on Daily Living and Adherence to Therapy

The effect of meibomian gland dysfunction treatment on sleep quality

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