Sleep Oscillations in the Thalamocortical System Induce Long-Term Neuronal Plasticity

Chauvette, Sylvain; Seigneur, Josée; Timofeev, Igor

doi:10.1016/j.neuron.2012.08.034

Cited by 266 publications

(220 citation statements)

References 50 publications

(63 reference statements)

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“…Chauvette et al (2012) showed that somatosensory cortical-evoked local field potentials are upregulated after the first epochs of NREMS [78]. Grosmark et al (2012) measured hippocampal firing rates during sequences of sleep stages [79].…”

Section: Novel Forms Of Synaptic Plasticitymentioning

confidence: 99%

Manipulating sleep spindles – expanding views on sleep, memory, and disease

Astori

Wimmer²,

Lüthi³

2013

Trends in Neurosciences

127

113

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Abstract:Sleep spindles are distinctive electroencephalographic (EEG) oscillations emerging during non-rapid-eye-movement sleep (NREMS) that have been implicated in multiple brain functions, including sleep quality, sensory gating, learning and memory. Despite considerable knowledge about the mechanisms underlying these neuronal rhythms, their function remains poorly understood and current views are largely based on correlational evidence. Here, we review recent studies in humans and rodents that have begun to broaden our understanding of the role of spindles in the normal and disordered brain. We show that newly identified molecular substrates of spindle oscillations, in combination with evolving technological progress, offer novel targets and tools to selectively manipulate spindles and dissect their role in sleep-dependent processes. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationAstori et al. Highlights Newly recognized ion channel subtypes generating spindle rhythms are described. The contribution of spindles to arousal threshold and sleep quality is discussed. The proposed role of spindles in memory consolidation is examined. A function of thalamic spindles in neural development is suggested. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 4 Previous excellent reviews have thoroughly described cellular and network bases of spindle generation [3,6,7]. Here, we first review recent work on genetic models that has expanded the mechanistic understanding of this EEG rhythm through the modification of novel molecular substrates. We then discuss the current views about the functional aspects of spindles in brain physiology and pathology, as obtained from studies in naturally sleeping animals and humans. We highlight studies indicating that spindles are accessible for selective interventions, and that, with emerging technologies, will open avenues to decipher spindle function. Novel molecular aspects of spindle generationSleep spindles emerge from a limited set of cellular participants: the resonating core of these waxing-and-waning oscillations resides in the nRt-TC loop, which sustains repetitive burst discharges of its cellular components under the control of cortical inputs (Figure 1 Another important factor in the generation and maintenance of reticular intrinsic oscillations is the aforementioned SK2 or Kcnn2 channel. The vigorous Ca 2+ influx in nRt dendrites originating from Ca V 3.3 channels gates SK2 channels, thereby creating a burstafterhyperpolarization (bAHP) [12,19]. As T channels recover partially from inactivation duri...

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Section: Novel Forms Of Synaptic Plasticitymentioning

confidence: 99%

Manipulating sleep spindles – expanding views on sleep, memory, and disease

Astori

Wimmer²,

Lüthi³

2013

Trends in Neurosciences

127

113

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“…Interestingly, when a memory is being encoded indicating its importance for future use in a test appears to increase the likelihood of that memory being consolidated in sleep (Wilhelm et al 2011). Our understanding of specific memory functions and neurobiological processes in sleep is increasing, yet there remain many issues requiring further research (Chauvette, Seigneur, and Timofeev 2012;Grosmark et al 2012). …”

Section: Other Educational Considerationsmentioning

confidence: 99%

Synchronizing education to adolescent biology: ‘let teens sleep, start school later’

Kelley

Lockley

Foster

et al. 2014

Learning, Media and Technology

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Arne Duncan, US Secretary of State for Education, tweeted in 2013: 'let teens sleep, start school later'. This paper examines early starts and their negative consequences in the light of key research in the last 30 years in sleep medicine and circadian neuroscience. An overview of the circadian timing system in adolescence leading to changes in sleep patterns is given and underpins the conclusion that altering education times can both improve learning and reduce health risks. Further research is considered from education, sleep medicine and neuroscience studies illustrating these improvements. The implementation of later starts is briefly considered in light of other education interventions to improve learning. Finally, the impact of introducing research-based later starts synchronized to adolescent biology is considered in practical and policy terms.Keywords: education; adolescence; school start times; circadian; sleep deprivation; learning; health Introduction Time is a fundamental variable in human biology and in education, yet currently the two disciplines measure time in different ways. For the educator, student development is defined by age and the daily timetable by social conventions that vary between countries, regions and even individual schools. In contrast, biological time is measured in developmental changes in the body, and over the day by our internal biological clock. It is no surprise given the relative novelty of mechanical clocks in evolutionary timescales that our ability to function optimally, including in learning, varies with biological time rather than conventional social times.

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“…The importance of reactivation to memory is clear from these systems-level studies. Circuit reactivation in slice is remarkably similar to activity in vivo during SWA 25,26 and provides a useful tool to examine synaptic plasticity in this context 13 . We find that circuit reactivations in vitro display stereotyped spatiotemporal patterns of neuronal activity consistent with observations of replay in vivo.…”

Section: Discussionmentioning

confidence: 96%

“…However, in contrast to classic experimental induction protocols, in vivo recordings show that reactivation of any one pattern of neuronal spikes is sparse and intermittent 2,4,5 . Recent work has demonstrated that slow-wave activity (SWA), which comprises UP and DOWN states, promotes long term potentiation (LTP), consistent with a role for SWA in memory consolidation 13,14 . However, linking endogenously generated spatiotemporal sequences and synaptic plasticity remains largely unexplored.…”

mentioning

confidence: 91%

Circuit reactivation dynamically regulates synaptic plasticity in neocortex

Kruskal

MacLean

2013

Nat Commun

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Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patchclamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the effect of the circuit on synaptic plasticity, we trigger a single spike-timing-dependent plasticity (STDP) pairing once per circuit reactivation. The pairings reliably fall within a particular epoch of the circuit sequence and result in longterm potentiation. During reactivation, the amplitude of plasticity significantly correlates with the preceding 20-25 ms of membrane depolarization rather than the depolarization at the time of pairing. This circuit-dependent plasticity provides a natural constraint on synaptic potentiation, regulating the inherent instability of STDP in an assembly phase-sequence model. Subthreshold voltage during endogenous circuit reactivations provides a critical informative context for plasticity and facilitates the stable consolidation of a spatiotemporal sequence.

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Sleep Oscillations in the Thalamocortical System Induce Long-Term Neuronal Plasticity

Cited by 266 publications

References 50 publications

Manipulating sleep spindles – expanding views on sleep, memory, and disease

Manipulating sleep spindles – expanding views on sleep, memory, and disease

Synchronizing education to adolescent biology: ‘let teens sleep, start school later’

Circuit reactivation dynamically regulates synaptic plasticity in neocortex

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