2024
DOI: 10.1101/2024.06.07.597897
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Sleep, NMDA Receptor Subunits, and the Compensatory Pathway: Understanding Contextual Fear Conditioning in the Absence of the Dorsal Hippocampus

Deepika Kant,
Sushil K. Jha

Abstract: The loss of the dorsal hippocampus (DH) results in profound deficits in contextual fear-conditioned (CxFC) memory. Nonetheless, CxFC memories can still form without the DH, specifically with multiple trials at three-day intervals. The infralimbic cortex (IL) is pivotal in initiating this compensatory process post-DH loss, but the precise factors remain elusive. Our study aims to delineate key factors of compensatory CxFC in DH absence by investigating the effects of sleep deprivation (SD) and NMDA receptor sub… Show more

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