Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men

Mullington, Janet; Chan, Jean L.; Dongen, Hans P A Van; Szuba, Martin P.; Samaras, J.; Price, Nicholas J.; Meier-Ewert, Hans K.; Dinges, David F.; Mantzoros, Christos S.

doi:10.1046/j.1365-2826.2003.01069.x

Cited by 226 publications

(186 citation statements)

References 27 publications

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“…Based on both clinical and experimental studies, insufficient sleep has been shown to associate with multiple metabolic and hormonal changes including reduction in glucose tolerance, increase in cortisol levels and sympathovagal response. 11,19,22 Besides, sleep deprivation is associated with reduced leptin and increased ghrelin levels, [23][24][25] both of which can increase appetite and, hence, possibly, weight gain.…”

Section: Discussionmentioning

confidence: 99%

Association between sleeping hours, working hours and obesity in Hong Kong Chinese: the ‘better health for better Hong Kong’ health promotion campaign

et al. 2006

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Objective: To study the inter-relationships between sleeping hours, working hours and obesity in subjects from a working population.Research design: A cross-sectional observation study under the 'Better Health for Better Hong Kong' Campaign, which is a territory-wide health awareness and promotion program. Subjects: 4793 subjects (2353 (49.1%) men and 2440 (50.9%) women). Their mean age (7s.d.) was 42.478.9 years (range 17-83 years, median 43.0 years). Subjects were randomly selected using computer-generated codes in accordance to the distribution of occupational groups in Hong Kong. Results: The mean daily sleeping time was 7.0671.03 h (women vs men: 7.1471.08 h vs 6.9870.96 h, Po0.001). Increasing body mass index (BMI) was associated with reducing number of sleeping hours and increasing number of working hours reaching significance in the whole group as well as among male subjects. Those with short sleeping hour (6 h or less) and long working hours (49 h) had the highest BMI and waist in both men and women. Based on multiple regression analysis with age, smoking, alcohol drinking, systolic and diastolic blood pressure, mean daily sleeping hours and working hours as independent variables, BMI was independently associated with age, systolic and diastolic blood pressure in women, whereas waist was associated with age, smoking and blood pressure. In men, blood pressure, sleeping hours and working hours were independently associated with BMI, whereas waist was independently associated with age, smoking, blood pressure, sleeping hours and working hours in men. Conclusion: Obesity is associated with reduced sleeping hours and long working hours in men among Hong Kong Chinese working population. Further studies are needed to investigate the underlying mechanisms of this relationship and its potential implication on prevention and management of obesity.

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Section: Discussionmentioning

confidence: 99%

Association between sleeping hours, working hours and obesity in Hong Kong Chinese: the ‘better health for better Hong Kong’ health promotion campaign

et al. 2006

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“…The discrepancy of these results is not known, but may be due to the type I error (due to the small sample size), and the heterogeneous nature of human sample population, such as differences in living environment, nutrition, and medication status. Variation in narcolepsy symptomatology, such as degree of sleep disturbance across samples, may affect leptin results [18]. All of the factors mentioned above have been reported to affect serum leptin levels.…”

Section: Discussionmentioning

confidence: 99%

Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

Fujiki

Yoshida²,

Zhang³

et al. 2006

Peptides

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Recent studies in human and animal models of narcolepsy have suggested that obesity in narcolepsy may be due to deficiency of hypocretin signaling, and is also under the influence of environmental factors and the genetic background. In the current study, using two hypocretin/orexin deficient narcoleptic mouse models (i.e. prepro-orexin knockout (KO) and orexin/ataxin-3 transgenic (TG) mice) with cross-sectional assessments, we have further analyzed factors affecting obesity. We found that both KO and TG narcoleptic mice with mixed genetic backgrounds (N4-5, 93.75-96.88 % genetic composition of C57BL/6) tended to be heavier than wild type (WT) mice of 100 to 200 days old. The body weight of heterozygous mice was intermediate between those of KO and WT mice. Obesity was more prominent in females in both KO and TG narcoleptic mice and was associated with higher serum leptin levels, suggesting a partial leptin resistance. Obesity is less prominent in the congenic TG narcoleptic mice, but is still evident in females. Our results confirmed that hypocretin/orexin ligand deficiency is one of the critical factors for the obese tendency in narcolepsy. However, multiple factors are also likely to affect this phenotype, and a gender specific alteration of leptin-hypocretin signaling may be involved.

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“…Eighty-eight hours of total sleep deprivation with scheduled meals designed to maintain body weight resulted in a decrease in the amplitude of the leptin diurnal variation without change in body weight. 55 The nocturnal rise of ghrelin is modestly, but significantly, reduced during acute total sleep deprivation as compared to normal nocturnal sleep. 46 In the laboratory study that subjected healthy men to 4-hour bedtimes for 6 nights followed by 6 nights of 12-hour recovery sleep, mean leptin levels were 19% lower, the nocturnal acrophase was 2 hours earlier and 26% lower and the amplitude of the diurnal variation was 20% lower during sleep restriction.…”

Section: Laboratory Studies Of Leptin and Ghrelin During Sleep Lossmentioning

confidence: 98%

The metabolic consequences of sleep deprivation

Knutson

Spiegel

Penev

et al. 2007

Sleep Medicine Reviews

1,105

767

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The prevalence of diabetes and obesity is increasing at an alarming rate worldwide, and the causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior that has developed over the past 2-3 decades. Laboratory and epidemiological studies suggest that sleep loss may play a role in the increased prevalence of diabetes and/or obesity. Current data suggest the relationship between sleep restriction, weight gain and diabetes risk may involve at least three pathways: 1. alterations in glucose metabolism; 2. upregulation of appetite; 3. decreased energy expenditure. The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk.

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Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men

Cited by 226 publications

References 27 publications

Association between sleeping hours, working hours and obesity in Hong Kong Chinese: the ‘better health for better Hong Kong’ health promotion campaign

Association between sleeping hours, working hours and obesity in Hong Kong Chinese: the ‘better health for better Hong Kong’ health promotion campaign

Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

The metabolic consequences of sleep deprivation

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