Sleep interventions for osteoarthritis and spinal pain: a systematic review and meta-analysis of randomized controlled trials

Ho, Kevin K.; Ferreira, Paulo H.; Pinheiro, Marina B.; Silva, D. Aquino; Grunstein, Ron; Simić, Milena

doi:10.1016/j.joca.2018.09.014

Cited by 47 publications

(30 citation statements)

References 67 publications

(209 reference statements)

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“…The interrelations between sleep and pain have been well characterized over the past two decades, with epidemiological, experimental, and clinical research providing broad support for a bidirectional relationship [98]. Consistent with these findings, a number of studies have linked sleep problems with increased pain and pain sensitivity among individuals with OA [108,109,110,111,112], which suggests that sleep could be an important treatment target for reducing OA pain—although clinical trials have not always supported that premise [113].…”

Section: Introductionmentioning

confidence: 99%

Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis

Rice

McNair

Huysmans

et al. 2019

JCM

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Osteoarthritis (OA) is a leading cause of chronic pain and disability in older adults, which most commonly affects the joints of the knee, hip, and hand. To date, there are no established disease modifying interventions that can halt or reverse OA progression. Therefore, treatment is focused on alleviating pain and maintaining or improving physical and psychological function. Rehabilitation is widely recommended as first-line treatment for OA as, in many cases, it is safer and more effective than the best-established pharmacological interventions. In this article, we describe the presentation of OA pain and give an overview of its peripheral and central mechanisms. We then provide a state-of-the-art review of rehabilitation for OA pain—including self-management programs, exercise, weight loss, cognitive behavioral therapy, adjunct therapies, and the use of aids and devices. Next, we explore several promising directions for clinical practice, including novel education strategies to target unhelpful illness and treatment beliefs, methods to enhance the efficacy of exercise interventions, and innovative, brain-directed treatments. Finally, we discuss potential future research in areas, such as treatment adherence and personalized rehabilitation for OA pain.

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Section: Introductionmentioning

confidence: 99%

Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis

Rice

McNair

Huysmans

et al. 2019

JCM

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“…Interestingly, a twin study has found that although genetics plays a contributing role, the majority of covariance (57.5%) between sleep quality and LBP is largely attributable to unique environmental factors (Pinheiro et al, 2018). Therefore, considering the modifiable nature of sleep quality, earlier and frequent screening for indicators of poor sleep quality with appropriate referral to sleep interventions (i.e., interventions targeting improved sleep quality and reduced pain in sleep) may improve LBP management (Ho et al, 2019) and potentially reduce health-care utilization by people with chronic LBP. Furthermore, similar to existing studies, we did not find an association between seeking care for LBP and various lifestyle and health factors.…”

Section: Comparison To Literaturementioning

confidence: 99%

Factors associated with seeking medical care for low back pain in a twin adult sample

Ferreira

Pinheiro

et al. 2021

European Journal of Pain

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Background: Previous studies have only investigated how symptom presentation and socio-demographic factors influence care-seeking for low back pain (LBP).However, the influence of health and lifestyle factors remains unclear, and the potential confounding effects of aggregated familial factors (including genetics and the early shared environment) has not been considered extensively. Methods: A cross-sectional analysis was performed on 1605 twins enrolled in the Murcia Twin Registry (Spain). The outcome was seeking medical care for LBP and various self-reported demographic, health and lifestyle factors were considered predictors. All variables except sleep quality and diabetes were collected in 2013, which were cross-referenced from 2009 to 2010. A multivariate logistic regression model was performed on the total sample, followed by a co-twin case-control analysis. Results: The only significant factor found to increase the odds of seeking medical care for LBP without being affected by familial factors was poor sleep quality (total sample OR = 1.58, 95%CI 1.24-2.01; case-control OR = 1.75, 95%CI 1.14-2.69).The factors that were associated with reduced odds of seeking medical care for LBP and not confounded by familial factors were male sex (case-control OR = 0.55, 95%CI 0.33-0.93), alcohol intake (case-control OR = 0.90, 95%CI 0.82-0.99) and a history of diabetes (case-control OR = 0.50, 95%CI 0.25-0.97). No other factors significantly influenced medical care-seeking for LBP. Conclusions: People reporting poor sleep quality are more likely to seek medical care for LBP in the long term, with this relationship being independent from aggregated familial factors. Conversely, males, people reporting higher alcohol intake, and people with a history of diabetes are less likely to seek medical care for LBP. Significance: This is the first study investigating the factors that influence seeking medical care for LBP, while adjusting for the influence of familial factors using a co-twin control design. Poor sleep quality is associated with seeking medical care for LBP in the long term and does not appear to be confounded by familial factors. Early screening for indicators of poor sleep quality and appropriate referral to interventions for improving sleep quality or reducing pain in sleep may improve LBP management.

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“…The relationship between sleep problems and pain has been extensively investigated in prior cross-sectional studies. Traditionally, it has been thought that the two conditions are related reciprocally in a bidirectional manner [ 11 ]; however, there is accruing evidence suggesting that sleep problems are more significant predictors of pain than vice versa [ 12 – 14 ]. A recent systematic review and meta-analysis concluded that decline in sleep quality and quantity was linked to a two- to three-times risk of developing pain conditions [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Sleep Disturbance and Its Association with Pain Severity and Multisite Pain: A Prospective 10.7-Year Study

et al. 2020

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Introduction Sleep disturbance is often comorbid with chronic pain disorders, with emerging evidence suggesting a stronger effect of sleep disturbance on pain than vice versa; however, few studies have evaluated the long-term associations between sleep disturbance and pain. This study was to examine the associations of sleep disturbance with knee pain severity, number of painful sites (NPS) and persistent pain in a 10.7-year cohort study. Methods A total of 1099 community-dwelling older adults (age mean ± SD, 63 ± 7.5 years; 51% female) were recruited and followed up at 2.6, 5.1 and 10.7 years later. Data on demographics, body mass index, physical activity and comorbidities were collected. At each time point, sleep disturbance, knee pain severity and NPS were assessed by using questionnaires. Multisite pain (MSP) was defined as NPS ≥ 2. Persistent knee pain or MSP was defined as having knee pain or MSP at all time points, respectively. Multivariable mixed-effects models and log-binomial regression were applied. Results In multivariable analyses, sleep disturbance was associated with greater knee pain severity ( β 0.91/unit, 95% CI 0.70–1.11) and more NPS [(relative risk (RR) 1.10/unit, 95% CI 1.07–1.14] in a dose–response manner. Persistent sleep disturbance was associated with persistent knee pain (RR 1.90, 1.26–2.87) and MSP (RR 1.29, 1.07–1.56). Persistent knee pain and MSP were also associated with persistent sleep disturbance (knee pain: RR = 1.99; MSP: RR = 2.71, both P < 0.05). Conclusions Sleep disturbance was independently associated with greater pain severity and NPS in a dose–response manner. A reciprocal relationship between persistent sleep disturbance and persistent pain suggests treating either problem could help the other. Electronic Supplementary Material The online version of this article (10.1007/s40122-020-00208-x) contains supplementary material, which is available to authorized users.

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Sleep interventions for osteoarthritis and spinal pain: a systematic review and meta-analysis of randomized controlled trials

Cited by 47 publications

References 67 publications

Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis

Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis

Factors associated with seeking medical care for low back pain in a twin adult sample

Sleep Disturbance and Its Association with Pain Severity and Multisite Pain: A Prospective 10.7-Year Study

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