Sleep-insomnia superposition: opposing brain signatures of sleep in task-based and resting-state conditions

Abstract

Sleep and mental health have complex relationships, with sleep-associated alterations in brain dynamics and structure impacting a range of symptoms and cognitive abilities. We analyzed the correlations between task and resting-state brain-wide signatures of sleep, cognition, and depression in over 30,000 individuals. Insomnia and depression correlated negatively with sleep duration at task condition, but positively at resting-state with an associated hyperconnectivity disputing conventional assumptions and suggesting hyperarousal-insomnia link.