Sleep induced by the administration of melatonin (5-methoxy-N-acetyltryptamine) to the hypothalamus in unrestrained cats

Marczynski, T.J.; Yamaguchi, Nariyoshi; Ling, George M.; Grodzínska, L

doi:10.1007/bf02152134

Cited by 146 publications

(27 citation statements)

References 4 publications

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“…The doses used in the study show a comparable effect as the therapeutic dosages. Therefore, although melatonin is an effective hypnotic agent both in animals (17,18) and humans (19), these findings suggest that melatonin may not directly affect the hypnotic action of zaleplon.…”

Section: Discussionmentioning

confidence: 96%

Effect of Zaleplon, a Non-benzodiazepine Hypnotic, on Melatonin Secretion in Rabbits

Noguchi¹,

Kitazumi²,

Mori³

et al. 2003

J Pharmacol Sci

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Abstract. Melatonin, a major hormone secreted by the pineal gland, is known to play an important role in regulation of the circadian rhythm. (N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) is a non-benzodiazepine hypnotic that acts via the benzodiazepine site of the GABA A receptor. In the present study, we investigated the effect of zaleplon on melatonin secretion in rabbits using RIA and compared the effect to triazolam and zopiclone. Zaleplon increased a dose-dependent concentration of melatonin in rabbit plasma collected at 30 min after intravenous administration at doses of 1 and 2 mg / kg. The zaleploninduced increase in plasma melatonin level was not blocked by flumazenil, a benzodiazepinereceptor antagonist. In contrast, triazolam and zopiclone failed to affect the plasma melatonin level. We also investigated the effect of zaleplon on intracellular cAMP in rat pinealocytes. Consequently, zaleplon had no effect on the intracellular cAMP levels in rat pinealocytes. These results of the present studies suggest that zaleplon may promote melatonin secretion and the elevation of plasma levels of melatonin may suggest an influence of zaleplon on chronobiology.

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Section: Discussionmentioning

confidence: 96%

Effect of Zaleplon, a Non-benzodiazepine Hypnotic, on Melatonin Secretion in Rabbits

Noguchi¹,

Kitazumi²,

Mori³

et al. 2003

J Pharmacol Sci

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“…From the results, the following may be presumed: 1) The administration of the above four drugs will enhance the secretion and the metabolism of melatonin. Sugden (24) and Lieberman et al (25) reported that a significant and short time sedative effect was observed by the adminis tration of melatonin to man or rat, whereas for animals (26) or humans (27), melatonin acts as an effective hypnotic agent. Therefore, melatonin has sedative and anticonvulsant effects similar to the actions of DZP, HYZ, CPZ and HPD.…”

Section: Discussionmentioning

confidence: 99%

Effect of psychotropic drugs on the contents of melatonin, serotonin and N-acetylserotonin in rat pineal gland.

et al. 1989

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Abstract-In the dark phase, the effects of the psychotropic drugs on the contents of melatonin, serotonin (5-HT) and N-acetylserotonin (NAS) in rat pineal gland were examined. The pineal gland was removed at a certain period of time after subcutaneous injection of the drugs. 5-HT, NAS and melatonin contents in the pineal gland were determined by high performance liquid chromatography with fluorometric detection. A dose-dependent decrease was observed for melatonin content in the administration of diazepam (DZP), hydroxyzine (HYZ), chlorprom azine (CPZ) or haloperidol (HPD). When imipramine (IPM) or amitriptyline (APL) was given to rats, pineal 5-HT content was significantly decreased. On the other hand, the administration of IPM or APL caused increases in pineal NAS and melatonin. Furthermore, the administration of phenytoin (PYT) revealed no changes in the content of pineal indoleamines. These results suggest that the psychotropic drugs widely used in clinical applications could cause significant changes in pineal indoleamine content.

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“…Me latonin is known to be taken up [1] and specifically bound [30, 44] in the hypothalamus of the laboratory rat and has been visualized in this region by using fluorescence immunohistochemistry [5]. Crystals of melatonin implanted into the brain cause reduction of luteinizing hormone in the rat [II,14], and melatonin administration has been shown to induce behavioral and EEG changes in other species [2,21,26], The present study was undertaken to verify a brain site of melatonin action in a photoperiodic species, the white-footed mouse. The experimental approach involved implantation of melatonin-beeswax pellets either in the brain or subcutaneously.…”

mentioning

confidence: 99%

Evidence for a Brain Site of Melatonin Action in the White-Footed Mouse, <i>Peromyscus leucopus</i>

Gr²

1982

Neuroendocrinology

105

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A brain site of melatonin action has been determined for the white-footed mouse (Peromyscus leucopus). Melatonin-beeswax implants releasing small quantities of melatonin (<100 ng/day) caused a 50% reduction in reproductive tract weight relative to controls (p < 0.025) with 83% of these animals having an imperforate vagina, when implanted in the anterior hypothalamic nuclei (AH) and suprachiasmatic nuclei (SCN). Subcutaneous implants had little effect. Implants in the AH and SCN also had a pronounced effect on both lipid-free interscapular brown fat and nesting behavior. Mice implanted in these regions exhibited a 59% increase in interscapular brown fat and 65% more nesting than controls (both p < 0.01). These results suggest that melatonin acts at a region in the anterior hypothalamus which controls photoperiodic adjustments.

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Sleep induced by the administration of melatonin (5-methoxy-N-acetyltryptamine) to the hypothalamus in unrestrained cats

Cited by 146 publications

References 4 publications

Effect of Zaleplon, a Non-benzodiazepine Hypnotic, on Melatonin Secretion in Rabbits

Effect of Zaleplon, a Non-benzodiazepine Hypnotic, on Melatonin Secretion in Rabbits

Effect of psychotropic drugs on the contents of melatonin, serotonin and N-acetylserotonin in rat pineal gland.

Evidence for a Brain Site of Melatonin Action in the White-Footed Mouse, <i>Peromyscus leucopus</i>

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