Sleep in Neurology

Abstract

and Narcology, Kharkiv, Ukraine In epileptic patients sleep disorders present with different frequency and their particular clinical phenomenology. The aim -is this a link between seizure frequency and severity of sleep disorders. Methods: Patients were selected on seizure frequency: group I (n = 27; 20.93%) included patients with seizure frequency (s.f.) 1-2 seizures year )1 [mean duration of epilepsy (m.d.) was 7.01 ± 5.4; mean age (m.a.) 31.2 ± 7.1]. They had partial (n = 22; 81.48%), generalized seizures (n = 5; 18.52%). Group II (n = 59; 45.73%) s.f. 2-5 seizures/six months [m.d. 12.2 ± 4.3; m.a. 29.1 ± 3.5]; partial (n = 45; 76.27%), generalized (n = 14; 23.73%). Group III (n = 43; 33.3%) s.f. 1-4 seizures/month [m.d. 14.7 ± 6.2; m.a. 38.7 ± 8.9 years]; partial (n = 24; 55.8%), generalized (n = 19; 44.19 %).Results: The most common disorders in patients were sleepiness at daytime and presomnia (group In = 11; 40.74 %; group IIn = 29; 49.15 %; group IIIn = 38; 88.37 %). Night-sleep abnormalities were in eight patients (29.63 %, group I), in 25 patients (42.37 %, group II), in 33 patients (76.74 %, group III). In four patient (9.3%, group III) hypnagogic hallucinations were observed. Somnambulism, speaking during night sleep were in two patients (7.4%, group I), in two patients (3.39%, group II), 15 patients (34.88%, group III). In structure of epilepsy bright/frighten dreams-like aura presented (group In = 5; 18.52%; group IIn = 11; 18.64%; group IIIn = 19; 44.19%). Episodes of sleep with oneirodynias were in three patients (II group -5.08 %), nine patients (III group -20.93%). Sleep disorders frequency depended on seizure frequency both in group III and group II: RIII = +0.51 (P < 0.01); RII = +0.38 (P < 0.01) and duration of epilepsy RIII = +0.52 (P < 0.01); RII = +0.44 (P < 0.02). RI-frequency = +0.29 (P > 0.05); RI-duration = +0.24 (P > 0.05). Conclusion: Factor that may influence on/or predict/increase seizure frequency is presence of sleep disorders. Because of high sleepdisorder's frequency in epileptics EEG-monitoring all day long is needed for all patients with night seizures and sleep disordersÕ drug treatment may lead to better seizure control because of their adverse effect on epilepsy.P436 Morphological studies of the cerebral ischaemia and hypoxia revealed not degenerative only but also restorative processes in the brain tissue, including stem cells proliferation (Dirnagl U., et al. Pathobiology of ischaemic stroke: an integrated view. TINS (1999) 22, 391-397). On the other hand, classical studies of Ian Oswald clearly demonstrated a paramount role of the natural sleep in tissue restoration (Oswald I. AustriaChiari malformations (CM) subsume several forms of congenital or acquired malformations with cerebellar herniation through the foramen magnum. This may lead to brainstem compression and result in various neurologic symptoms. It may also be associated with blunted ventilatory and arousal responses, central hypoventilation syndrome and increased central and obstructive apnea. Sleep disordered...