Sleep in cluster headache − beyond a temporal rapid eye movement relationship?

Barloese, Mads; Jennum, Poul; Lund, Nunu; Jensen, Rigmor Højland

doi:10.1111/ene.12623

Cited by 55 publications

(89 citation statements)

References 36 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are mostly in accordance with our previous sleep study of 40 patients with CH (eCH in bout and chronic CH) and 25 healthy controls . Both studies found lower sleep efficiency, longer sleep latency and REM sleep latency in ‘active’ patients, but we could not confirm a lower REM sleep density.…”

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period

Lund¹,

Snoer²,

Petersen³

et al. 2018

Euro J of Neurology

Self Cite

View full text Add to dashboard Cite

Background and purpose Cluster headache (CH) is characterized by severe, unilateral attacks of pain and a high nocturnal attack burden. It remains unknown whether perturbations of sleep are solely present during the CH bout. Therefore, we aimed to investigate differences in sleep between the bout and remission period in patients with episodic CH and, secondly, to compare patients in the two phases with controls. Methods Patients with episodic CH (aged 18–65 years), diagnosed according to the International Classification of Headache Disorders 2nd edition, were admitted for polysomnography at the Danish Center for Sleep Medicine in bout and in remission. The macrostructure of sleep, including arousals, breathing parameters, limb movements and periodic limb movements, was compared with 25 age‐, sex‐ and body mass index‐matched healthy controls. Results There were no differences in any of the sleep parameters for patients in bout (n = 32) compared with patients in remission (n = 23). Attacks were unrelated to sleep stages, presence of apnea episodes, periodic limb movements, limb movements and arousals. In bout, patients had longer sleep latency (18.8 vs. 11.7 min, P < 0.05) and rapid eye movement sleep latency (1.7 vs. 1.2 h, P < 0.05) than controls and sleep efficiency was lower (82.5% vs. 86.5%, P < 0.05). Patients in remission only had a longer sleep latency compared with controls (17.5 vs. 11.7 min, P < 0.01). Conclusions The results support the presence of a continuing or slowly recovering disturbance of sleep outside the bout rather than a disturbance occurring secondary to attacks. Further, we confirm that there is no relation between CH attacks and specific sleep stages or between CH and breathing parameters.

show abstract

Section: Discussionsupporting

confidence: 85%

“…This complicates establishment of sleep versus wake, potentially resulting in altered scoring of breathing parameters . This may explain the discrepancy from our findings . Interestingly, AHI tended to be lower on attack nights compared with attack‐free nights, an observation that could not be explained by differences in age and BMI.…”

Section: Discussioncontrasting

confidence: 78%

Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period

Lund¹,

Snoer²,

Petersen³

et al. 2018

Euro J of Neurology

Self Cite

View full text Add to dashboard Cite

show abstract

“…When this higher sympathetic tone is withdrawn, rebound parasympathetic hyperactivity, as is seen during physical (Lahiri et al ., ) and psychological (Mezzacappa et al ., ) stress, could theoretically be the trigger of disease mechanisms. This harmonizes with previous findings indicating that CH attacks arise in close temporal proximity to shifts in autonomic tone (Graham, ; Barloese et al ., ).…”

Section: Discussionsupporting

confidence: 92%

Sphenopalatine ganglion stimulation induces changes in cardiac autonomic regulation in cluster headache

Barloese

Petersen

Guo

et al. 2017

Clin Physio Funct Imaging

View full text Add to dashboard Cite

In cluster headache patients subjected to low-frequency and sham stimulation of the sphenopalatine ganglion, we found changes indicating higher sympathetic tone during low-frequency stimulation preceding cranial autonomic symptoms or cluster pain. During cluster pain, regardless of stimulation parameters, we saw increased parasympathetic activity, congruent with previous reports. The results indicate involvement of cardiac autonomic regulation before and during cluster headache attacks.

show abstract

“…Other differences between episodic and chronic patients regarding pain location, side change frequency, autonomic features, and attack duration have been reported as quite minimal . Sleep studies have suggested that the frequent nocturnal attacks may be associated with either REM sleep or the shift between sleep phases in eCH but not in cCH although no major differences exist in sleep architecture …”

Section: Discussionmentioning

confidence: 99%

Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

et al. 2019

View full text Add to dashboard Cite

Objective and Background The diagnostic criteria of episodic and chronic cluster headache (cCH) were recently modified, yet pathophysiological differences between the two are still unclear. The aim of this cross‐sectional study is to identify and characterize other differences between episodic and cCH. Methods Data from a retrospective, questionnaire‐ and interview‐based study were analyzed with a focus on associated factors including traumatic head injury (THI), familial history, and change of phenotype. Attack patterns were analyzed using Gaussian and spectral modeling. Results 400 patients and 200 controls participated. A positive family history was more prevalent in chronic than episodic cluster headache (eCH) (34/146 (23%) vs 33/253 (13%), respectively, P = .008). A history of THI was more common in patients than controls (173/400 (43%) vs 51/200 (26%), respectively, P < .0001) and in chronic compared to eCH (77/146 (53%) vs 96/253 (37%), respectively, P = .004). Patients with a positive family history had a unique diurnal attack pattern with twice the risk of nocturnal attacks as patients who did not report family history. Patients reporting phenotype change had a chronobiological fingerprint similar to the phenotype they had experienced a transition into. A higher attack frequency in chronic patients was the only difference in symptom manifestation across all analyzed subgroups of patients. Conclusions cCH is associated with a positive family history and THI. In familial CH, a peak in nocturnal chronorisk may implicate genes involved in diurnal‐, sleep‐ and homeostatic regulation. The stereotypical nature of the CH attacks themselves is confirmed and differences between subgroups should be sought in other characteristics.

show abstract

Sleep in cluster headache − beyond a temporal rapid eye movement relationship?

Cited by 55 publications

References 36 publications

Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period

Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period

Sphenopalatine ganglion stimulation induces changes in cardiac autonomic regulation in cluster headache

Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

Contact Info

Product

Resources

About