Sleep, Immunological Memory, and Inflammatory Skin Disease

Myers, Bridget; Reddy, Vidhatha; Chan, Si-Wa; Thibodeaux, Quinn; Brownstone, Nicholas; Bhutani, Tina

doi:10.1159/000510082

Cited by 10 publications

(9 citation statements)

References 51 publications

(50 reference statements)

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“…Other studies have shown that poor sleep can lead to increased pro-inflammatory cytokines, such as IL-17, resulting in immune skin diseases, such as vitiligo and psoriasis, which are driven by memory cells. 19 Additionally, 5 days of sleep restriction can shift the Th1/Th2 ratio toward Th2, potentially affecting Th2-mediated diseases such as atopic dermatitis. 20 This study is significant, as it validates the there is a decrease in the amount of moisture, skin damage recovery, skin texture, transparency, elasticity, and brightness, whereas there is an increase in desquamation and wrinkles.…”

Section: Discussionmentioning

confidence: 99%

“…This deteriorated sleep quality affects the skin. Other studies have shown that poor sleep can lead to increased pro‐inflammatory cytokines, such as IL‐17, resulting in immune skin diseases, such as vitiligo and psoriasis, which are driven by memory cells 19 . Additionally, 5 days of sleep restriction can shift the Th1/Th2 ratio toward Th2, potentially affecting Th2‐mediated diseases such as atopic dermatitis 20 .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of changes in skin characteristics due to the poor quality of sleep caused by smartphone usage

Jang

Jung

Lee

et al. 2021

J of Cosmetic Dermatology

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The skin is the outermost layer of the body and is exposed to various environmental conditions, and skin characteristics change along with the environmental conditions. Several studies evaluating variations in skin characteristics have attributed ultraviolet light and external humidity as the factors responsible for skin changes. Skin conditions vary considerably with drastic changes in humidity. Moisture in the skin decreases in an environment that changes from 70% humidity to 40% humidity. 1 There are also reports of a decrease in transepidermal water loss (TEWL) in those who work at low temperatures. 2 We are increasingly exposed to various environments, some of which have never existed before, such as fine dust, face cover/masks due to coronavirus disease (COVID-19) epidemic, and lack of sleep. It is worth noting that the number of studies related to sleep is increasing day by day. Some have reported changes in biophysical properties of skin, such as facial pore size, skin tone, skin hydration, elasticity, desquamation, translucency, and blood flow after constant sleep deprivation. 3 In addition, studies have shown that reduction of sleep from 8 to 4 h, even for 6 days, reduces elasticity and leads to skin aging. 4

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of changes in skin characteristics due to the poor quality of sleep caused by smartphone usage

Jang

Jung

Lee

et al. 2021

J of Cosmetic Dermatology

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show abstract

“…Over-representation of sleep disorders has been observed on patients with psoriasis, atopic dermatitis, hidradenitis suppurativa and vitiligo [21,22,23,24]. New works are studying the reverse effect of sleep deprivation on skin disease through the bi-directional relationship between sleep and the immune system [25]. This link is hypothesised to be contributing to the chronic inflammation observed in many skin diseases.…”

Section: Introductionmentioning

confidence: 99%

Inferring Skin-Brain-Skin Connections from Infodemiology Data using Dynamic Bayesian Networks

Scutari

Kérob

Salah

2023

Preprint

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The relationship between skin diseases and mental illnesses has been extensively studied using cross-sectional epidemiological data. Typically such data can only measure association (rather than causation) and include only a subset of the diseases we may be interested in. In this paper, we complement the evidence from such analyses by learning a dynamic Bayesian network over 12 health conditions from a Google search trends public data set. The resulting network model can represent both cyclic and acyclic causal relationships, is easy to interpret and accounts for the spatio-temporal trends in the data in a probabilistically rigorous way. The average R^2 for a condition given the values of all conditions in the previous week is 0.67: in particular, 0.42 for acne, 0.85 for asthma, 0.58 for ADHD, 0.87 for burn, 0.76 for erectile dysfunction, 0.88 for scars, 0.57 for alcohol disorders, 0.57 for anxiety, 0.53 for depression, 0.74 for dermatitis, 0.60 for sleep disorders and 0.66 for obesity. Results confirm the large number of cyclic relationships between the selected health conditions and the interplay between skin and mental diseases. For acne, we observed a cyclic relationship with anxiety and attention deficit hyperactivity disorder (ADHD) and an indirect relationship with depression through sleep disorders. For dermatitis, we observed directed links to anxiety, depression and sleep disorder and a cyclic relationship with ADHD. We also observe a link between dermatitis and ADHD and a cyclic relationship between acne and ADHD. Furthermore, the network includes several direct connections between sleep disorders and other health conditions, highlighting the impact of the former on the overall health and well-being of the patient. Mapping disease interplay, indirect relationships and the key role of mediators, such as sleep disorder, will allow healthcare professionals to address disease management holistically and more effectively. Even if all skin and mental diseases are considered jointly, each disease subnetwork is unique, allowing for more targeted interventions.

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“…Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:(REM) sleep [10]. Under ordinary conditions, rest and the circadian mood guarantee a mitigating state during the daytime and a pro-inflammatory state during the evening [9].…”

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confidence: 99%

Curcumin and Its Affection for Sleep Deprivation

Pandey¹,

Kumar²

2022

Preprint

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In this review, the following information describes the manifestation of sleep deprivation by human beings and its adverse effect on their health. Sleep deprivation has been demonstrated into namely two types known as REM sleep and NREM sleep affecting our health in so a problematic way that it is making our body immune to many diseases leading to lethal problems. Therefore, great research by many scientists has discovered that the turmeric “Curcuma longa” which is been used in every Indian kitchen since ancient times, has shown a remarkable effect on the problem caused by sleep deprivation but due to its poor solubility and low bioavailability drawn it into a great disadvantage. But the help of the study of nanotechnology and the evolution of curcumin into nano–curcumin made the possibility of the remarkable effect by making the curcumin more potent and enhancing its stability. Immunological changes due to sleep deprivation lead to Alzheimer’s disease, glioma, neuropathic pains, and many more. Therefore, this review has been summarized as it is been providing information related to curcumin and its affection for sleep deprivation.

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Sleep, Immunological Memory, and Inflammatory Skin Disease

Cited by 10 publications

References 51 publications

Evaluation of changes in skin characteristics due to the poor quality of sleep caused by smartphone usage

Evaluation of changes in skin characteristics due to the poor quality of sleep caused by smartphone usage

Inferring Skin-Brain-Skin Connections from Infodemiology Data using Dynamic Bayesian Networks

Curcumin and Its Affection for Sleep Deprivation

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