Sleep hypoxia and not obesity is the main determinant of the increasing monocyte chemoattractant protein-1 (MCP-1) in patients with obstructive sleep apnoea

Fanfulla, Francesco; Rotondi, Mario; Morrone, Elisa; Coperchini, Francesca; Lodigiani, Sara; Trentin, Rossella; Maccabruni, Valeria; Chiovato, Luca

doi:10.1183/23120541.sleepandbreathing-2017.p70

Cited by 2 publications

(2 citation statements)

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“…Moreover, it is secreted from adipose tissue to the circulation and may increase the hepatic expression of SREBP-1 [ 251 ]. Increased plasma levels of MCP-1 were detected in patients with OSA irrespective of obesity and correlated with ODI [ 252 , 253 ]. Furthermore, in the presence of IH, human adipocytes have a higher sensitivity to express pro-inflammatory genes [ 254 ].…”

Section: Further Mechanisms In Osa-associated Dyslipidaemiamentioning

confidence: 99%

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Mészáros

Bikov

2022

Biomedicines

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Obstructive sleep apnoea (OSA) is associated with cardiovascular and metabolic comorbidities, including hypertension, dyslipidaemia, insulin resistance and atherosclerosis. Strong evidence suggests that OSA is associated with an altered lipid profile including elevated levels of triglyceride-rich lipoproteins and decreased levels of high-density lipoprotein (HDL). Intermittent hypoxia; sleep fragmentation; and consequential surges in the sympathetic activity, enhanced oxidative stress and systemic inflammation are the postulated mechanisms leading to metabolic alterations in OSA. Although the exact mechanisms of OSA-associated dyslipidaemia have not been fully elucidated, three main points have been found to be impaired: activated lipolysis in the adipose tissue, decreased lipid clearance from the circulation and accelerated de novo lipid synthesis. This is further complicated by the oxidisation of atherogenic lipoproteins, adipose tissue dysfunction, hormonal changes, and the reduced function of HDL particles in OSA. In this comprehensive review, we summarise and critically evaluate the current evidence about the possible mechanisms involved in OSA-associated dyslipidaemia.

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Section: Further Mechanisms In Osa-associated Dyslipidaemiamentioning

confidence: 99%

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Mészáros

Bikov

2022

Biomedicines

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“…Increases may be associated with conditions other than UUTO or even non-kidney conditions. Increases in MCP-1 are associated with liver cirrhosis [ 115 ] and sleep apnea syndrome [ 116 ], increases in NGAL are associated with cardiovascular ischemia, heart failure, atherosclerosis, and pneumonia [ 117 , 118 ], and increases in L-FABP are associated with various liver diseases [ 119 , 120 ]. However, panel assessment may compensate for the lack of specificity.…”

Section: Current Limitations and Future Directionsmentioning

confidence: 99%

Roles Played by Biomarkers of Kidney Injury in Patients with Upper Urinary Tract Obstruction

Washino

Hosohata

Miyagawa

2020

IJMS

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Partial or complete obstruction of the urinary tract is a common and challenging urological condition caused by a variety of conditions, including ureteral calculi, ureteral pelvic junction obstruction, ureteral stricture, and malignant ureteral obstruction. The condition, which may develop in patients of any age, induces tubular and interstitial injury followed by inflammatory cell infiltration and interstitial fibrosis, eventually impairing renal function. The serum creatinine level is commonly used to evaluate global renal function but is not sensitive to early changes in the glomerular filtration rate and unilateral renal damage. Biomarkers of acute kidney injury are useful for the early detection and monitoring of kidney injury induced by upper urinary tract obstruction. These markers include levels of neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemotactic protein-1, kidney injury molecule 1, N-acetyl-b-D-glucosaminidase, and vanin-1 in the urine and serum NGAL and cystatin C concentrations. This review summarizes the pathophysiology of kidney injury caused by upper urinary tract obstruction, the roles played by emerging biomarkers of obstructive nephropathy, the mechanisms involved, and the clinical utility and limitations of the biomarkers.

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Sleep hypoxia and not obesity is the main determinant of the increasing monocyte chemoattractant protein-1 (MCP-1) in patients with obstructive sleep apnoea

Cited by 2 publications

References 0 publications

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Roles Played by Biomarkers of Kidney Injury in Patients with Upper Urinary Tract Obstruction

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