Sleep homeostasis and depression: Studies with the rat clomipramine model of depression

Savelyev, Sergey A.; Rantamäki, Tomi; Rytkönen, Kirsi-Marja; Ċastrén, Eero; Porkka‐Heiskanen, Tarja

doi:10.1016/j.neuroscience.2012.03.029

Cited by 24 publications

(18 citation statements)

References 55 publications

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“…In a pharmacologically induced depression model in males (clomipramine administration in early life) sleep homeostasis was impaired and characterized by a reduced increase in NREM sleep duration and delta power during recovery sleep. 11 The present study demonstrated a normal homeostatic NREM sleep response with increased delta power in CF treated male and female rats. Sleep deprivation for three hours is considered a minimum deprivation time, which causes physiological sleep homeostasis reflected in an increased NREM sleep duration and intensity, as well as in elevated basal forebrain adenosine level.…”

supporting

confidence: 66%

“…11,56,57 In the present study, both male and female CF rats weighed in adolescence less than CTRLs. This difference remained to adulthood in females,…”

mentioning

confidence: 42%

“…Adenosine and brain-derived neurotrophic factor (BDNF) have been proposed to participate in both regulation of sleep and depression. [7][8][9][10][11] The gender differences in the prevalence of mental disorders are large: major depression and anxiety disorder are approximately twice as common in women as in men. 12,13 While there is only modest evidence of sex differences in sleep parameters verified with EEG, 14 the epidemiological studies frequently demonstrate a large difference in sleep complains between the sexes, showing that females in all age groups report more sleep complaints than males.…”

Section: Introductionmentioning

confidence: 99%

“…Sleep deprivation for three hours is considered a minimum deprivation time, which causes physiological sleep homeostasis reflected in an increased NREM sleep duration and intensity, as well as in elevated basal forebrain adenosine level. 11,37 Longer sleep deprivation (6-24 h) could potentially induce different homeostatic responses in CF and control rats.…”

mentioning

confidence: 99%

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Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Santangeli

Lehtikuja

Palomäki

et al. 2016

Sleep

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Study Objective: Adverse early-life events induce behavioral psychopathologies and sleep changes in adulthood. In order to understand the molecular level mechanisms by which the maltreatment modifies sleep, valid animal models are needed. Changing pups between mothers at early age (cross-fostering) may satisfyingly model adverse events in human childhood. Methods: Cross-fostering (CF) was used to model mild early-life stress in male and female Wistar rats. Behavior and BDNF gene expression in the basal forebrain (BF), cortex, and hypothalamus were assessed during adolescence and adulthood. Spontaneous sleep, sleep homeostasis, and BF extracellular adenosine levels were assessed in adulthood. Results: CF rats demonstrated increased number of REM sleep onsets in light and dark periods of the day. Total REM and NREM sleep duration was also increased during the light period. While sleep homeostasis was not severely affected, basal level of adenosine in the BF of both male and female CF rats was lower than in controls. CF did not lead to considerable changes in behavior. Conclusions: Even when the consequences of adverse early-life events are not observed in tests for anxiety and depression, they leave a molecular mark in the brain, which can act as a vulnerability factor for psychopathologies in later life. Sleep is a sensitive indicator for even mild early-life stress.

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supporting

confidence: 66%

“…11,56,57 In the present study, both male and female CF rats weighed in adolescence less than CTRLs. This difference remained to adulthood in females,…”

mentioning

confidence: 42%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Santangeli

Lehtikuja

Palomäki

et al. 2016

Sleep

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“…Finally, it is also of interest to note that the pattern of activity/resting in alignment with the dark/light phases is significantly enhanced in the PhW. This can be taken as a sensitive measure of emotional behavior, given that alterations in these patterns are associated to mood disorders; 32,33 herein the disruption observed after stress and the reversal with fluoxetine treatment are strongly supportive of its relevance.…”

Section: Discussionmentioning

confidence: 94%

PhenoWorld: a new paradigm to screen rodent behavior

Castelhano-Carlos

Costa

Russig³

et al. 2014

Transl Psychiatry

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Modeling depression in animals has inherent complexities that are augmented by intrinsic difficulties to measure the characteristic features of the disorder. Herein, we describe the PhenoWorld (PhW), a new setting in which groups of six rats lived in an ethological enriched environment, and have their feeding, locomotor activity, sleeping and social behavior automatically monitored. A battery of emotional and cognitive tests was used to characterize the behavioral phenotype of animals living in the PhW and in standard conditions (in groups of six and two rats), after exposure to an unpredictable chronic mild stress paradigm (uCMS) and antidepressants. Data reveal that animals living in the PhW displayed similar, but more striking, behavioral differences when exposed to uCMS, such as increased behavioral despair shown in the forced swimming test, resting/sleep behavior disturbances and reduced social interactions. Moreover, several PhW-cage behaviors, such as spontaneous will to go for food or exercise in running wheels, proved to be sensitive indicators of depressive-like behavior. In summary, this new ethological enriched paradigm adds significant discriminative power to screen depressive-like behavior, in particularly rodent's hedonic behavior.

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The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression

Bhagya

Srikumar

Raju

et al. 2014

J of Neuroscience Research

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Depression is a major psychiatric illness that is associated with cognitive dysfunctions. The underlying mechanism of depression-associated memory impairment is unclear. Previously, we showed altered hippocampal synaptic plasticity in an animal model of depression. Although several antidepressants are beneficial in the treatment of depression, very little is known about the effects of these drugs on depression-associated learning and memory deficits. Prolonged antidepressant treatment might contribute to neuroplastic changes required for clinical outcomes. Accordingly, we evaluated the effect of chronic reboxetine (a selective noradrenergic reuptake inhibitor) treatment on depression-induced reduced hippocampal synaptic plasticity, neurotransmitter levels, and spatial learning and memory impairments. Depression was induced in male Wistar rats by the administration of clomipramine from postnatal days 8 to 21, and these rats were treated with reboxetine in adulthood. The neonatal clomipramine administration resulted in impaired hippocampal long-term potentiation (LTP), decreased hippocampal cholinergic activity and monoamine levels, and poor performance in a partially baited eight-arm radial maze task. Chronic reboxetine treatment restored the hippocampal LTP, acetylcholinesterase activity, and levels of biogenic amines and ameliorated spatial learning and memory deficits in the depressed state. Thus, restoration of hippocampal synaptic plasticity might be a cellular mechanism underlying the beneficial effect of reboxetine in depression-associated cognitive deficits. This study furthers the existing understanding of the effects of antidepressants on learning, memory, and synaptic plasticity and could ultimately assist in the development of better therapeutic strategies to treat depression and associated cognitive impairments.

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Sleep homeostasis and depression: Studies with the rat clomipramine model of depression

Cited by 24 publications

References 55 publications

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

PhenoWorld: a new paradigm to screen rodent behavior

The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression

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