Sleep health and diabetes: The role of sleep duration, subjective sleep, sleep disorders, and circadian rhythms on diabetes

Seixas, Azizi; Robbins, Rebecca; Chung, Alicia; Popp, Collin; Donley, Tiffany; McFarlane, Samy I.; Moore, Jesse; Jean‐Louis, Girardin

doi:10.1016/b978-0-12-815373-4.00017-4

Cited by 5 publications

(4 citation statements)

References 86 publications

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“…Even though experimental proofs put forth that being subject to hypoxia may trigger insulin resistance, the results on the relationship between OSAS and glucose level and insulin resistance are contradictory. Some studies have put forth that the plasma glucose levels are higher at a statistically significant level in OSAS patients in comparison with the controls [20,21]. However, Chung et al [22] reported that insulin resistance was related to obesity itself rather than OSAS severity or nocturnal hypoxemia-related variables in their study.…”

Section: Discussionmentioning

confidence: 85%

Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS

Çelikhisar¹,

Ilkhan

2020

Canadian Respiratory Journal

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Objective. The present study was planned to examine the relationships between obstructive sleep apnea syndrome (OSAS) and the newly revealed adipokines adropin and adiponectin concentrations that display significant metabolic and cardiovascular functions and the levels of proinflammatory cytokine levels. Method. A total of 166 overweight and obese male patients with a body mass index (BMI) >27 kg/m2 were included in the study. Among study participants, 84 were recently diagnosed with OSAS by polysomnography with an apnea-hypopnea index (AHI) ≥5, and 82 were nonapneic with normal polysomnography (AHI<5) findings. The serum adropin and adiponectin levels of all cases were analyzed via the enzyme-linked immunosorbent assay method. Serum interleukin-1 (IL-1) beta and tumor necrotizing factor-alpha (TNF-alpha) levels were determined using Luminex cytokine multiplex analyses. Results. The mean age of the OSAS patients was 50.9 ± 5.7 years and BMI was 32.4 ± 6.0 kg/m2, and there was no statistically significant difference determined with the control group (49.3 ± 5.8 years and 30.6 ± 5, 6 kg/m2) (p>0.05). There were no statistically significant differences between the OSAS and control groups concerning total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and glucose levels. Adiponectin was lower in the OSAS group at a statistically significant level in comparison with the control group and was related at a statistically significant level to OSAS intensity. Adropin concentration was determined to be higher in the OSAS group at a statistically significant level in comparison with the control group. Conclusion. The results of our study suggest that increased adropin concentration may be an indicator of endothelium dysfunction in OSAS patients. Serum adropin and adiponectin levels may be new bioindicators used for diagnosis and risk assessment in OSAS patients.

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Section: Discussionmentioning

confidence: 85%

Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS

Çelikhisar¹,

Ilkhan

2020

Canadian Respiratory Journal

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“…Assessments of other secondary insomnia complaints and sleep quality such as total sleep time and sleep onset latency were absent in the dataset. Incorporating these variables could have significantly enhanced the depth and comprehensiveness of our analyses [36,47,50]. Fourthly, we do not have access to information about obstructive sleep apnoea syndrome (OSAS) which could be an essential contributing factor to insomnia symptoms such as non-restorative sleep, and the information about the use of psychotropic drugs, all of which might affect both sleep and physical function.…”

Section: Discussionmentioning

confidence: 99%

Association of insomnia symptoms and trajectories with the risk of functional disability: a prospective cohort study

Huang,

Xie,

Chen

et al. 2024

BMC Geriatr

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Background There is limited understanding regarding prospective associations of insomnia symptoms and trajectories with functional disability. We aimed to investigate the associations of insomnia symptoms and trajectories with functional disability. Method A total of 13 197 participants were eligible from the Health and Retirement Study. Insomnia symptoms included non-restorative sleep, difficulty initiating sleep, early morning awakening, and difficulty maintaining sleep. We also identified four distinct trajectories of insomnia symptoms: low, decreasing, increasing, and high insomnia symptoms. Functional status was assessed through activities of daily living (ADL) and instrumental activities of daily living (IADL). Results Participants experiencing one (HR, 1.21; 95% CI, 1.13–1.29), two (HR, 1.43; 95% CI, 1.29–1.57), or three to four (HR, 1.41; 95% CI, 1.25–1.60) insomnia symptoms had a higher risk of ADL disability than asymptomatic respondents. Similarly, participants with one or more insomnia symptoms had a higher risk of IADL disability. Furthermore, using the trajectory with low insomnia symptoms as the reference, decreasing insomnia symptoms (HR, 1.22; 95% CI, 1.12–1.34), increasing insomnia symptoms (HR, 1.21; 95% CI, 1.05–1.41), and high insomnia symptoms (HR, 1.36; 95% CI, 1.18–1.56) were all associated with an increased risk of ADL disability. Conclusion Both a single measurement and dynamic trajectory of insomnia symptoms are associated with the onset of ADL disability. Increased awareness and management of insomnia symptoms may contribute to the prevention of functional disability occurrence.

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“…21,[45][46][47][48] These biological markers could subsequently and over time lead to the development of, or exacerbate, adverse health conditions, including obesity, diabetes, hypertension, coronary heart disease, heart failure, 21,45,47 emotional, mental, and psychological disorders (e.g., stress, anxiety, depression, alcohol dependence, suicidality), and cognitive impairments such as Alzheimer's or other dementias, and could contribute to functional limitations or loss of independence. 1,45,49,50 These medical conditions could also result in subsequent insomnia symptoms 2,5 and are the leading causes of higher HSU. 51,52 Another plausible mechanism that indirectly links insomnia symptoms to HSU is the effect of inadequate or maladaptive health behaviors such as alcohol, nicotine, and tobacco use, poor physical activity, poor diet quality, opiates, cannabis, and other substance use among individuals with the insomnia symptoms.…”

Section: Theoretical Frameworkmentioning

confidence: 99%

“…More specifically, insomnia symptoms are implicated in several distinct or complex and overlapping biological mechanisms such as increased blood pressure, dysregulation or increased cortisol secretion, increased proinflammatory biomarkers, impaired glucose metabolism and insulin resistance, vascular dysfunction, and impaired clearance of beta‐amyloid and other wasteful products from the brain 21,45–48 . These biological markers could subsequently and over time lead to the development of, or exacerbate, adverse health conditions, including obesity, diabetes, hypertension, coronary heart disease, heart failure, 21,45,47 emotional, mental, and psychological disorders (e.g., stress, anxiety, depression, alcohol dependence, suicidality), and cognitive impairments such as Alzheimer's or other dementias, and could contribute to functional limitations or loss of independence 1,45,49,50 . These medical conditions could also result in subsequent insomnia symptoms 2,5 and are the leading causes of higher HSU 51,52 .…”

Section: Introductionmentioning

confidence: 99%

Longitudinal associations between time‐varying insomnia symptoms and all‐cause health care services utilization among middle‐aged and older adults in the United States

Mahmood

Kedia

Dobalian

et al. 2022

Health Services Research

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Objective: To examine longitudinal associations between time-varying insomnia symptoms (difficulty initiating sleep, difficulty maintaining sleep, early-morning awakenings, and nonrestorative sleep) and all-cause health care services utilization (HSU), including overnight hospital stays, nursing home stays, and home health care services among middle-aged and older adults.Data Sources: The Health and Retirement Study (HRS), a nationwide, populationrepresentative survey of primarily middle-aged and older adults in the United States.Study Design: This study is an analysis of prospective data from the HRS for a cohort of 13,168 adults (aged ≥50 years; females = 57.7%). Study participants were followed for 16 years. This study focuses on the associations between time-varying insomnia symptoms, both cumulatively and independently, and repeated HSUs. A marginal structural modeling approach was used to capture time-varying biological, psycho-cognitive, and behavioral health factors, and to adjust for selection bias such as differential loss to follow-up. Generalized estimating equations were employed to compute average marginal effects and their 95% confidence intervals.Data Collection/Extraction Methods: We extracted longitudinal data from 2002 through 2018 waves of the HRS.Principal Findings: Experiencing higher numbers of insomnia symptoms on a cumulative scale was associated with higher probabilities of HSU. For instance, the likelihood of overnight hospital stays for individuals reporting one symptom increased from 4.7 percentage points on average (95% CI: 3.7-5.6, p < 0.001), to 13.9 percentage points (95% CI: 10.3-17.5, p < 0.001) for those reporting four symptoms, relative to individuals experiencing no insomnia symptoms. Further, experiencing each of difficulty initiating and maintaining sleep, and nonrestorative sleep, as standalone symptoms, was associated with a higher likelihood of HSU when compared to those not experiencing the symptoms. Conclusions:The results demonstrate the potential consequences and adverse impacts of insomnia symptoms on HSU among middle-aged and older adults. Future investigations should focus on the underlying causes and health systems pathways linking insomnia symptoms to HSU.

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Sleep health and diabetes: The role of sleep duration, subjective sleep, sleep disorders, and circadian rhythms on diabetes

Cited by 5 publications

References 86 publications

Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS

Alterations in Serum Adropin, Adiponectin, and Proinflammatory Cytokine Levels in OSAS

Association of insomnia symptoms and trajectories with the risk of functional disability: a prospective cohort study

Longitudinal associations between time‐varying insomnia symptoms and all‐cause health care services utilization among middle‐aged and older adults in the United States

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