Sleep Fragmentation in Mice Induces Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2-Dependent Mobilization, Proliferation, and Differentiation of Adipocyte Progenitors in Visceral White Adipose Tissue

Wang, Yang; Zhang, Shelley X.; Qiao, Zhuanhong; Abdelkarim, Amal; Gozal, David

doi:10.5665/sleep.3678

Cited by 30 publications

(26 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is possible that use of Resv as a dietary supplement in sleep disorder patients manifesting metabolic dysfunction may improve the latter via its antioxidant properties (28), since increased oxidative stress is clearly elicited by SF and promotes insulin resistance (2,3). However, the beneficial impact of Resv on the inflammatory phenotype of VWAT would suggest that the increased activation of inflammatory pathways elicited by SF (3) was reversed by Resv.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

“…SF also imposes adverse metabolic consequences such as increased appetite and food intake that ultimately promote the emergence of obesity (1,2).…”

Section: Introductionmentioning

confidence: 99%

Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Conceptualised as a chronic, low‐grade, inflammatory state, obesity is characterised by increased circulating inflammatory markers . Animal models confirm that poor sleep increases nicotinamide adenine dinucleotide phosphate activity in visceral white adipose tissue, producing adipose progenitors that lead to obesity and insulin resistance in sleep‐deprived mice …”

Section: Discussionmentioning

confidence: 99%

Time spent watching television impacts on body mass index in youth with obesity, but only in those with shortest sleep duration

Golshevsky

Magnussen

Juonala

et al. 2019

J Paediatrics Child Health

View full text Add to dashboard Cite

Aim:To determine the interplay between sleep and sedentary behaviours on body mass index (BMI) in children with obesity. Methods: Cross-sectional study of 343 children with obesity aged 4-17 years, from a tertiary care weight management clinic in Melbourne, Victoria, Australia. Multifaceted data relating to activity and sleep from child and parent questionnaires analysed with anthropometric data collected during routine clinical care. Associations between sleep duration and activity measures were examined via regression models with adjustment for potential confounders. Results: Higher BMI was associated with more hours spent watching television (P = 0.04), as well as less reported enjoyment of physical activity (P = 0.005) and less time spent in organised sport activity (P = 0.005). Higher BMI was also associated with higher levels of obstructive sleep apnoea (P = 0.002). Less time in bed was associated with higher levels of BMI (P = 0.03) but analysis by sex revealed this association to only hold for males. In the whole group, a significant television and sleep interaction was seen, such that increasing television watching was associated with higher BMI, but only in those with shortest sleep duration. Conclusions: Both poor sleep and increasing screen time (including television viewing, smart-phone use, internet use or video-gaming) appear to impact BMI in children with obesity, with a particular detrimental effect of television viewing in those who sleep less. Efforts to improve sleep time and quality in children may minimise negative effects of screen time on increasing BMI and should be included in public health strategies to combat obesity in childhood.

show abstract

“…Thus, disrupted sleep such as occurs in OSAS markedly accelerates tumor progression and invasion even in the absence of intermittent hypoxia (IH; see below). More recent work from our laboratory has further indicated that in sharp contrast with other tissues, such as brain and adipose tissues (50–53), in which SF promotes increased NADPH oxidase activity, the opposite, i.e., reduced NADPH oxidase activity and expression occur within the solid tumor microenvironment, and underlie components of the increased aggressiveness of the tumor under SF conditions (54). These recent findings have prompted substantial interest and should lead to enhanced research efforts (55).…”

Section: Introductionmentioning

confidence: 99%

Obstructive sleep apnea and cancer: Epidemiologic links and theoretical biological constructs

Gozal

Farré

Nieto

2016

Sleep Medicine Reviews

Self Cite

101

View full text Add to dashboard Cite

SUMMARY Sleep disorders have emerged as highly prevalent conditions in the last 50–75 years. Along with improved understanding of such disorders, the realization that perturbations in sleep architecture and continuity may initiate, exacerbate or modulate the phenotypic expression of multiple diseases including cancer has gained increased attention. Furthermore, the intermittent hypoxia that is attendant to sleep disordered breathing, has recently been implicated in increased incidence and more adverse prognosis of cancer. The unifying conceptual framework linking these associations proposes that increased sympathetic activity and/or alterations in immune function, particularly affecting innate immune cellular populations, underlie the deleterious effects of sleep disorders on tumor biology. In this review, the epidemiological evidence linking disrupted sleep and intermittent hypoxia to oncological outcomes, and the potential biological underpinnings of such associations as illustrated by experimental murine models will be critically appraised. The overarching conclusion appears supportive in the formulation of an hypothetical framework, in which fragmented sleep and intermittent hypoxia may promote changes in multiple signalosomes and transcription factors that can not only initiate malignant transformation, but will also alter the tumor microenvironment, disrupt immunosurveillance, and thus hasten tumor proliferation and increase local and metastatic invasion. Future bench-based experimental studies as well as carefully conducted and controlled clinical epidemiological studies appear justified for further exploration of these hypotheses.

show abstract

Sleep Fragmentation in Mice Induces Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2-Dependent Mobilization, Proliferation, and Differentiation of Adipocyte Progenitors in Visceral White Adipose Tissue

Cited by 30 publications

References 62 publications

Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea

Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea

Time spent watching television impacts on body mass index in youth with obesity, but only in those with shortest sleep duration

Obstructive sleep apnea and cancer: Epidemiologic links and theoretical biological constructs

Contact Info

Product

Resources

About