Sleep Duration and Frailty Risk among Older Adults: Evidence from a Retrospective, Population-Based Cohort Study

Chen, Shixiang; Wang, Yulu; Wang, Z.; Zhang, X.; Deng, Cuiyu; Ma, Bingxin; Yang, Juntang; Lu, Qi; Zhao, Yue

doi:10.1007/s12603-022-1766-z

Cited by 10 publications

(8 citation statements)

References 47 publications

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“…However, many older adults report difficulties with sleep latency, sleep fragmentation, or altered sleep duration. The evidence states that sleep disturbances affect 9% to 50% of older adults throughout the world 22,33–35. It has been found that a bidirectional relationship exists between sleep impairments and frailty.…”

Section: Fried's Phenotypementioning

confidence: 99%

“…The evidence states that sleep disturbances affect 9% to 50% of older adults throughout the world. 22,[33][34][35] It has been found that a bidirectional relationship exists between sleep impairments and frailty. Moreno-Tamayo et al 33 ascertained women experiencing sleep disturbances had a 3 times higher likelihood of frailty.…”

Section: Poor Sleep Qualitymentioning

confidence: 99%

“…Frailty has bidirectional relationships with various conditions such as depression 20 (Figure 3), insomnia, [20][21][22] malnutrition, 23 and fatigue. 23 Often their presentations are entangled, thus making it difficult for a clinician to determine what to prioritize first.…”

Section: Fried's Phenotypementioning

confidence: 99%

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Physical Therapist Management of a Person With Frailty Across the Continuum

Cabrera

2023

Topics in Geriatric Rehabilitation

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Management of the older adult with frailty is challenging. Multiple morbidities and their interrelationships can make the management of frailty arduous to diagnose and effectively treat. However, explicitly assessing for frailty can help optimize the older adult's care and provide an appropriate focus for the interventions. Effective treatment interventions must be individualized to encourage active participation and engagement. Appropriate dosing of exercise is essential. Nonetheless, the key to reversing or preventing a downward trajectory is increasing physical activity, necessitating the individual's active participation and empowerment.

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Section: Fried's Phenotypementioning

confidence: 99%

Section: Poor Sleep Qualitymentioning

confidence: 99%

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Physical Therapist Management of a Person With Frailty Across the Continuum

Cabrera

2023

Topics in Geriatric Rehabilitation

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“…Quality sleep can have a significant influence on neurocognitive functioning [ 157 , 158 , 159 ]. However, age-related sleep disturbance is common [ 160 , 161 ]. Besides the adverse psychological effects lack of sleep causes, its negative effect on glymphatic functioning is also noteworthy [ 162 , 163 ].…”

Section: Potential Interventionsmentioning

confidence: 99%

Relationships between Inflammation and Age-Related Neurocognitive Changes

Jin

Chan

et al. 2022

IJMS

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The relationship between inflammation and age-related neurocognitive changes is significant, which may relate to the age-related immune dysfunctions characterized by the senescence of immune cells and elevated inflammatory markers in the peripheral circulation and the central nervous system. In this review, we discuss the potential mechanisms, including the development of vascular inflammation, neuroinflammation, organelle dysfunctions, abnormal cholesterol metabolism, and glymphatic dysfunctions as well as the role that the key molecules play in the immune-cognition interplay. We propose potential therapeutic pharmacological and behavioral strategies for ameliorating age-related neurocognitive changes associated with inflammation. Further research to decipher the multidimensional roles of chronic inflammation in normal and pathological aging processes will help unfold the pathophysiological mechanisms underpinning neurocognitive disorders. The insight gained will lay the path for developing cost-effective preventative measures and the buffering or delaying of age-related neurocognitive decline.

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“…However, since most of the studies included were cross-sectional, causal relationships between sleep duration and frailty could not be inferred. A longitudinal study showed that both short and long sleep duration were associated with incident frailty in Mexico (8), whereas Chen et al reported that only long sleep duration was associated with increased risks of frailty among older adults in China (9). Another study found that short sleep duration was not associated with frailty at follow-up investigations (10).…”

Section: Introductionmentioning

confidence: 99%

Association between daytime nap duration and risks of frailty: Findings from the China Health and Retirement Longitudinal Study

Zhang

Zhou

et al. 2023

Front. Public Health

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IntroductionNight sleep duration and total sleep duration are associated with frailty. However, the association between daytime nap duration and the risks of frailty has not been explored thoroughly.MethodsThis study used data from the China Health and Retirement Longitudinal Study (CHARLS). Participants aged 60 years and older at baseline were included in this study. Individuals with daytime nap duration were categorized into four groups: no napping, short napping (< 30 min), moderate napping (30–89 min), and extended napping (≥90 min). Frailty was assessed using a modified Physical Frailty Phenotype (PFP) scale. Non-frail participants at baseline were followed up for 4 years. The association between nap duration and risks of frailty at baseline and incident frailty was evaluated by logistic regression and discrete-time Cox regression analyses, respectively.ResultsIn total, 5,126 participants were included in this study. For individuals with night sleep duration of ≥9 h, short nappers showed higher odds [odds ratio (OR) = 4.08, 95% confidence interval (CI): 1.30–12.78] for frailty compared with non-habitual nappers at baseline, while moderate nappers were less likely to be frail (OR = 0.18, 95% CI: 0.04–0.73). In the follow-up study, short nappers showed higher risks for frailty compared with participants of the no napping group with night sleep duration of < 6 h [hazard ratio (HR) = 1.91, 95% CI: 1.07–3.43] or 6–9 h (HR = 1.97, 95% CI: 1.18–3.30). Compared with short nappers, older adults with extended napping (HR = 0.41, 95% CI: 0.22–0.77) showed lower risks for frailty in those with night sleep duration of 6–9 h. For individuals with night sleep duration of ≥9 h, moderate napping (HR = 0.20, 95% CI: 0.05–0.77) decreased the risks for frailty compared with short napping.ConclusionAmong older adults with night sleep duration of < 9 h, short nappers posed higher risks for frailty compared with non-habitual nappers. Extended naps for those with a night sleep duration of 6–9 h or moderate naps for those with night sleep duration of ≥9 h could lower the risk of frailty compared with short naps. Future studies on the timing, purpose, frequency, and quality of daytime napping and objectively measured nap duration are needed to explore the association between daytime napping and risks of frailty.

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Sleep Duration and Frailty Risk among Older Adults: Evidence from a Retrospective, Population-Based Cohort Study

Cited by 10 publications

References 47 publications

Physical Therapist Management of a Person With Frailty Across the Continuum

Physical Therapist Management of a Person With Frailty Across the Continuum

Relationships between Inflammation and Age-Related Neurocognitive Changes

Association between daytime nap duration and risks of frailty: Findings from the China Health and Retirement Longitudinal Study

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