Sleep Duration and Diabetes Risk: Population Trends and Potential Mechanisms

Grandner, Michael A.; Seixas, Azizi; Shetty, Safal; Shenoy, Sundeep

doi:10.1007/s11892-016-0805-8

Cited by 132 publications

(75 citation statements)

References 180 publications

(220 reference statements)

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“…This contrasting finding may be explained by the fact that, while IL-6 is often described as a proinflammatory cytokine marker of inflammation, it also does have anti-inflammatory properties [88,89]. Specifically, the primary roles of IL-6 are largely coupled with the regulation of the other two proinflammatory cytokines IL-1β and TNF-α, and studies have reported that IL-6 often inhibits the expression of IL-1β and TNF-α while promoting IL-10 [90]. This has been suggested to be especially so when in an anti-inflammatory environment, where the integrity of the blood-brain barrier needs to be regulated [91], such as during the occurrence of neuroinflammatory responses.…”

Section: Brain Alterations In Relation To Inflammation and Oxidative mentioning

confidence: 99%

Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective

2020

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Post-traumatic stress disorder (PTSD) is a chronic condition characterized by symptoms of physiological and psychosocial burden. While growing research demonstrated signs of inflammation in PTSD, specific biomarkers that may be representative of PTSD such as the detailed neural correlates underlying the inflammatory responses in relation to trauma exposure are seldom discussed. Here, we review recent studies that explored alterations in key inflammatory markers in PTSD, as well as neuroimaging-based studies that further investigated signs of inflammation within the brain in PTSD, as to provide a comprehensive summary of recent literature with a neurological perspective. A search was conducted on studies published from 2009 through 2019 in PubMed and Web of Science. Fifty original articles were selected. Major findings included elevated levels of serum proinflammatory cytokines in individuals with PTSD across various trauma types, as compared with those without PTSD. Furthermore, neuroimaging-based studies demonstrated that altered inflammatory markers are associated with structural and functional alterations in brain regions that are responsible for the regulation of stress and emotion, including the amygdala, hippocampus, and frontal cortex. Future studies that utilize both central and peripheral inflammatory markers are warranted to elucidate the underlying neurological pathway of the pathophysiology of PTSD.

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Section: Brain Alterations In Relation To Inflammation and Oxidative mentioning

confidence: 99%

Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective

2020

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“…6 Another pathway specifically important for noise is sleep disturbance, which can influence cardiometabolic functions through decreased leptin secretion, potentially increasing appetite, obesity and impaired glucose tolerance. 7 Correlating well with other markers of subclinical atherosclerosis, thoracic aortic calcification (TAC) independently predicts cardiovascular events and has a higher prevalence among middle-aged adults than coronary artery calcification (CAC). 8,9 It is therefore well suited for quantitative longitudinal analyses in middleaged populations.…”

Section: Introductionmentioning

confidence: 98%

Investigation of air pollution and noise on progression of thoracic aortic calcification: results of the Heinz Nixdorf Recall Study

Hennig

Moebus

Reinsch

et al. 2019

Eur J Prev Cardiolog

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Aims Air pollution and noise are potential risk factors for subclinical atherosclerosis. Longitudinal analyses, especially on the interplay of these environmental factors, are scarce and inconsistent. Hence we investigated long-term traffic-related exposure to air pollution and noise with the development and progression of thoracic aortic calcification, a marker of subclinical atherosclerosis. Methods We used baseline (2000–2003) and follow-up (2006–2008) data from the German Heinz Nixdorf Recall cohort study, including 4814 middle-aged adults. Residence-based air pollution (PM2.5 (aerodynamic diameter ≤ 2.5 µm), PM10, nitrogen dioxide and particle number), and noise was assessed with dispersion models. Thoracic aortic calcification was quantified from non-contrast enhanced electron beam computed tomography. The presence and extent of thoracic aortic calcification progression were analysed with multiple logistic and linear regression models, respectively, adjusting for age, sex, lifestyle variables, socioeconomic status and respective co-exposure. Results We observed no association in the full study sample ( n = 3155, mean age 59.1 (±7.6) years, 52.8% women). While an interquartile range in particle number and night-time noise yielded odds ratios of 1.20 (1.03, 1.40) and 1.21 (1.00, 1.46) for binary thoracic aortic calcification progression, and 0.02 (–0.01, 0.05) and 0.04 (0.00, 0.07) higher growth rates of thoracic aortic calcification in participants with baseline thoracic aortic calcification less than 10, negative findings were observed in those with baseline thoracic aortic calcification of 10 or greater. Results were similar for other pollutants and daytime noise. Conclusion Our study shows no overall associations. Subgroup analyses suggest independent associations of traffic-related air pollution and noise with the development and progression of subclinical atherosclerosis in participants with no or minor thoracic aortic calcification at baseline, in contrast to negative findings in those with advanced calcification.

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“…Long sleep duration as well as short sleep duration has been linked to increased all-cause mortality among older people. [3,4] Additionally, laboratory-and epidemiologically-based studies have shown that self-reported short and long sleep durations were associated with increased risks of cardiovascular disease, [5] diabetes mellitus, [6,7] obesity, [6] poor cognitive performance, [8,9] and poor self-rated health. [10] Sleep apnoea is a main cause for inadequate sleep duration.…”

Section: Introductionmentioning

confidence: 99%