“…71 Acute and chronic pain disrupt sleep, with difficulty falling or staying asleep, poor subjective sleep quality, short sleep duration, or disrupted sleep architecture. 49,72,150,186 Conversely, experimental and clinical data indicate that sleep deprivation lowers the pain threshold, lowers the cognitive ability to cope with pain, and increases ratings of pain intensity, which in turn exacerbates poor sleep. 145,146,149 Sleep disturbance can aggravate pain and inflammatory processes, reduce endogenous pain inhibitory responses, and increase emotional distress and reduce well-being.…”