Sleep disturbances, socioeconomic status, and seizure control as main predictors of quality of life in epilepsy

Alanis-Guevara, I.; Peña, Esteban Gilberto Ramos; Corona, Teresa; López-Ayala, Temuchino; López-Meza, Elmer; López-Gómez, Mario

doi:10.1016/j.yebeh.2005.06.010

Cited by 107 publications

(75 citation statements)

References 18 publications

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“…(8)(9)(10)(11)(12)(13)(14) 51 (33%) Clinical insomnia (moderate severity) (15)(16)(17)(18)(19)(20)(21) 63 (41%) Clinical insomnia (severe) (22)(23)(24)(25)(26)(27)(28) 15 (10%) Most patients were found to have low depressive scores, and this may be secondary to partial and/or successful treatment. Depression represents one of the most common comorbidities of epilepsy and has profound negative impact on the quality of life of patients.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Polysomnogram studies of patients with epilepsy have shown disrupted sleep with increased sleep onset latency, increased number of nocturnal awakenings, and altered sleep architecture. [6][7][8][9] Despite the increasing recognition of sleep disturbances as predictors of quality of life in these patients, 1,[10][11][12] insomnia in epilepsy has been poorly investigated. Some studies have focused on the impact of antiepileptic drugs (AEDs) on sleep quality.…”

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confidence: 99%

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Insomnia and Epilepsy: A Questionnaire-Based Study

Vendrame

Yang

Jackson

et al. 2013

Journal of Clinical Sleep Medicine

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Study Objectives: Although disturbed sleep has been frequently reported in patients with seizures, little is known about insomnia and epilepsy. The aims of this study were (1) to analyze the prevalence and degree of insomnia in patients with epilepsy, (2) to examine the clinical features and correlates of insomnia in these patients, and (3) to evaluate the impact of poor sleep on their quality of life. Methods: One hundred-fi fty-two patients with epilepsy (mean age 46 years) completed the following questionnaires: Insomnia Severity Index, Pittsburgh Sleep Quality Index, Beck Depression Inventory-II, Quality of Life in Epilepsy Inventory-31. Patients with other known sleep disorders, including obstructive sleep apnea, were excluded from the study. Regression analysis was conducted for adjusting for age, years since epilepsy onset, number of antiepileptic drugs, comorbidities, and depression scores.Results: More than half of the participants (55%) suffered from insomnia and more than 70% were "poor sleepers." Insomnia and poor sleep quality were signifi cantly correlated with the number of antiepileptic medications and scores of depressive symptoms. After controlling for covariates, insomnia and poor sleep quality were signifi cant predictors of lower quality of life. Conclusion: These results suggest that insomnia and poor sleep are common in patients with epilepsy and may adversely impact quality of life. Further studies should examine whether improvements in sleep can improve seizure control and quality of life of these patients.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Insomnia and Epilepsy: A Questionnaire-Based Study

Vendrame

Yang

Jackson

et al. 2013

Journal of Clinical Sleep Medicine

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“…[4] epilepsinin gelişimini ve süresini yaşam kalitesine etkisiz bulurken, diğer çalışmalarda [5,24,25] epilepsi süresinin artması ile yaşam kalitesinin azaldığı bulunmuştur. Bizim çalışmamızda hastaların genç olması ve hastalık sürelerinin görece kısa olması hastalığın yaşam kalitesi üzerine etkisiz olmasına neden olmuş olabilir.…”

Section: Discussionunclassified

“…[3] Yapılan çalışmalarda düşük sosyo-ekonomik durum, [4][5][6][7][8] depresyon, [9][10][11][12][13] uyku bozuklukları [4,14] ve sık nöbet geçirme-nin [4][5][6][7][15][16][17][18][19][20] epilepsi hastalarında yaşam kalitesini olumsuz etkilediği gösterildiğinden, bu faktörlerin bilinmesi tedavi başarısı ve hastanın yaşam kalitesini artırmak açısından önemlidir.…”

Section: Introductionunclassified

Quality of Life and Sleep in Young Male Patients with Epilepsy

Yaşar¹,

Alay²,

Kendirli³

et al. 2014

Epilepsi

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SummaryObjectives: In epilepsy patients many factors affect the quality of the life and sleep. The determinations of these factors are important in the dimension of improving both quality of life and sleeping. The aim of our study is to examine how socio-economic and clinical variables might influence the quality of life and sleep in young male patients with epilepsy. Methods: Participants were recruited from our outpatient clinic and diagnosed as epilepsy by a neurologist. Only male patients were included. All patients completed a semi-structured interview form for epilepsy patients as well as the Quality of Life in Epilepsy Inventory (QOLIE-31), the Beck Depression Inventory (BDI) and Pittsburgh Sleep Disorders Index (PSDI) under the supervision of the same neurology specialist. Finally, obtained test results in epilepsy patients were evaluated and examined the relationship among socio-economic and clinical factors. Results: The lowest score of the QOLIE-31 sub-scores of the patients were about "seizure concern". Age, duration of the disease and drug use did not significantly effect the total scores of QOLIE-31, BDI and PSDI. QOLIE-31 total scores of patients with moderate-to-good level of economic status were better than the ones with poor economic status. Patients with frequent number of seizures had more concerns and burnout than the ones with rare number of seizures. Also sleep disorder scores were worse with the patients who had frequent seizures. Conclusion: Epilepsy patients have high anxiety to have seizure. On the other hand low economic status, having frequent number of seizures, sleep disturbances and presence of depressive symptoms decrease the quality of life. Detection and correction of these factors would improve sleep and quality of life in these patients and also would increase treatment compliance and success.Key words: Exacerbation frequency; depressive symptoms; epilepsy; socioeconomic status; sleep disturbances; quality of life. ÖzetAmaç: Epilepsi hastalarının yaşam ve uyku kalitesini birçok faktör etkilemektedir. Bu faktörlerin tanınması yaşam ve uyku kalitesinin artırıl-ması açısından önemlidir. Çalışmamızın amacı, genç erkek epilepsi hastalarında sosyo-ekonomik ve klinik değişkenlerin, yaşam kalitesi ve uykuyu nasıl etkileyebileceğini incelemektir. Gereç ve Yöntem:Çalışmaya hastanemizin Nöroloji Polikliniği'nde epilepsi tanısı konulmuş ve izlem altında olan erkek hastalar alındı. Tüm hastalara, aynı nöroloji uzmanının gözetimi altında, epilepsi hastaları için yarı yapılandırılmış bir görüşme formunun yanında Epilepside Yaşam Kalitesi Ölçeği (EYK-31), Beck Depresyon Ölçeği (BDÖ) ve Pittsburgh Uyku Bozuklukları İndeksi (PUKİ) uygulandı. Son olarak elde edilen test sonuçlarının epilepsi hastalarında sosyo-ekonomik ve klinik faktörler ile ilişkisi değerlendirildi. Bulgular:Hastalarımızın Epilepside Yaşam Kalitesi-31 (EYK-31) ölçeği alt skorlarında en düşük skor nöbet endişesinde izlendi. Yaş, hastalık ve ilaç kullanım sürelerinin EYK-31 toplam skoru, BDÖ ve PUKİ skorları üzerine anlamlı etk...

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“…Sleep problems are frequent in children with epilepsy and are a major determinant of quality of life for people with epilepsy and their carers. 1 Proxy quality of life measures in Dravet syndrome have been shown to be worse than in other drug-resistant epilepsies. The work of Licheni et al is a valuable contribution in understanding why this is the case and crucially to suggest a modifiable comorbidity.…”

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confidence: 99%