Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis

Shi, Le; Chen, Sijing; Ma, Mengying; Bao, Yanping; Han, Ying; Wang, Yumei; Shi, Jie; Vitiello, Michael V.; Lü, Lin

doi:10.1016/j.smrv.2017.06.010

Cited by 569 publications

(343 citation statements)

References 68 publications

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“…Sleep‐disordered breathing was a risk factor for all‐cause dementia, Alzheimer's disease (AD), and vascular dementia. In contrast, insomnia increased the risk for AD but not for vascular or all‐cause dementia . Sleep disturbances are common (25–40%) in AD patients .…”

Section: Sleep and Dementiamentioning

confidence: 96%

“…In contrast, insomnia increased the risk for AD but not for vascular or all-cause dementia. 104 Sleep disturbances are common (25-40%) in AD patients. 105 Sleep problems in these patients are a serious concern as they further adversely affect the behavioural and psychological symptoms of dementia and also increase the risk factors associated with patients' day-to-day activities.…”

Section: Sleep and Dementiamentioning

confidence: 99%

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Sleep disorders in the elderly: a growing challenge

2018

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In contrast to newborns, who spend 16-20 h in sleep each day, adults need only about sleep daily. However, many elderly may struggle to obtain those 8 h in one block. In addition to changes in sleep duration, sleep patterns change as age progresses. Like the physical changes that occur during old age, an alteration in sleep pattern is also a part of the normal ageing process. As people age, they tend to have a harder time falling asleep and more trouble staying asleep. Older people spend more time in the lighter stages of sleep than in deep sleep. As the circadian mechanism in older people becomes less efficient, their sleep schedule is shifted forward. Even when they manage to obtain 7 or 8 h sleep, they wake up early, as they have gone to sleep quite early. The prevalence of sleep disorders is higher among older adults. Loud snoring, which is more common in the elderly, can be a symptom of obstructive sleep apnoea, which puts a person at risk for cardiovascular diseases, headaches, memory loss, and depression. Restless legs syndrome and periodic limb movement disorder that disrupt sleep are more prevalent in older persons. Other common medical problems of old age such as hypertension diabetes mellitus, renal failure, respiratory diseases such as asthma, immune disorders, gastroesophageal reflux disease, physical disability, dementia, pain, depression, and anxiety are all associated with sleep disturbances.

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Section: Sleep and Dementiamentioning

confidence: 96%

Section: Sleep and Dementiamentioning

confidence: 99%

Sleep disorders in the elderly: a growing challenge

2018

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“…Sleep disturbances are common in the elderly, with as many as 50% of those aged over 65 years reporting a chronic sleep complaint (Neikrug & Ancoli-Israel, 2010). Numerous studies have examined the association between disturbed sleep and cognitive performance in the elderly (Leng, McEnvoy, Allen, & Yaffe, 2017;Shi et al, 2018). Some of these studies have reported that insomniatype symptoms in community-dwelling elderly people are associated with cognitive decline (Basta et al, 2018;Cricco, Simonisick, & Foley, 2001;Jelicic et al, 2002).…”

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confidence: 99%

Associations between sleep duration and cognitive impairment in mild cognitive impairment

Basta

Simos

Vgontzas

et al. 2019

Journal of Sleep Research

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Summary The prevalence of mild cognitive impairment (MCI) increases among elderly people and is associated with a high risk of dementia. Identifying factors that may contribute to the progress of MCI to dementia is critical. The objective of this study was to examine the association of objective sleep with cognitive performance in MCI patients. A subsample of 271 participants with a diagnosis of probable Alzheimer's disease (AD; N = 50) or mild cognitive impairment (MCI; N = 121) and 100 persons who were not cognitively impaired (NI) were recruited from a large population‐based cohort in the island of Crete, Greece (3140 older adults aged >60 years). All participants underwent extensive neuropsychiatric/neuropsychological evaluation and a 3‐day 24‐hr actigraphy. Objective sleep variables and their association with neuropsychological performance were examined across the three groups, controlling for demographics, body mass index, depression, sleep apnea symptoms and psychotropic medications. Patients with AD had significantly longer 24‐hr total sleep time (TST) compared to the MCI and NI groups. Long 24‐hr TST was associated with reduced performance on tasks that placed significant demands on attention and processing speed in the MCI group and the AD group. Elderly patients with MCI have similar objective sleep duration to normal controls, whereas AD patients sleep longer. Long sleep duration in patients with multidomain subtypes of MCI is associated with critical non‐memory cognitive domains. It appears that within the MCI group those that sleep longer have more severe cognitive impairment.

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“…Both cognitive impairment and insomnia are two common and significant health problems in the elderly. Compared with individuals without insomnia, subjects who reported insomnia had a higher risk of all‐cause dementia, Alzheimer disease, and vascular dementia . The use of hypnotics including benzodiazepines (BZDs) and non‐BZDs is inevitable for patients with insomnia.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and clinical risk factors of insomnia in the Chinese elderly based on comprehensive geriatric assessment in Chongqing population

Zou

Chen

et al. 2019

Psychogeriatrics

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Background Insomnia is a major public health problem affecting older people. This study aimed to investigate the prevalence and clinical risk factors of insomnia in a representative sample of Chinese elderly (≥ 60 years) in Chongqing. Methods A cross‐sectional study based on comprehensive geriatric assessment was conducted from January 2013 to February 2014. A questionnaire on sleep status was provided to each patient and insomnia was assessed according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria. A multivariate logistic regression model was used to illustrate risk factors correlated with insomnia. Results Of the total 597 participants, 55.4% suffered from insomnia. The prevalence of insomnia in men and women was 48.2% and 63.2%, respectively. Coronary heart disease, dizziness, chronic pain, anorexia, malnutrition, depression and cognitive decline were identified as risk factors associated with insomnia. Hypertension, diabetes, hyperlipidaemia, headache, age and education level were not observed to be significantly associated with insomnia. Conclusions Insomnia is highly prevalent among the elderly in Chongqing, and shows a positive correlation to coronary heart disease, dizziness, chronic pain, anorexia, malnutrition, depression, cognitive impairment. Moreover, women are more likely to experience insomnia than men.

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Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis

Cited by 569 publications

References 68 publications

Sleep disorders in the elderly: a growing challenge

Sleep disorders in the elderly: a growing challenge

Associations between sleep duration and cognitive impairment in mild cognitive impairment

The prevalence and clinical risk factors of insomnia in the Chinese elderly based on comprehensive geriatric assessment in Chongqing population

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