Sleep disturbances in patients with lung cancer in Turkey

Bülbül, Yılmaz; Özlü, Tevfik; Arınç, Sibel; Özyürek, Berna Akıncı; Günbatar, Hülya; Şentürk, Ayşegül; Bahadır, Ayşe; Özçelik, Melike; Yılmaz, Ufuk; Akbay, Makbule Ozlem; Sağlam, Leyla; Kılıç, Talat; Kırkıl, Gamze; Özçelik, Neslihan; Tatar, Dursun; Barış, Serap Argun; Yavsan, Durdu Mehmet; Şen, Hadice Selimoğlu; Berk, Serdar; Acat, Murat; Çakmak, Gülfidan; Yumuk, Perran Fulden; İntepe, Yavuz Selim; Toru, Ümran; Ayık, Sibel; Başyiğit, İlknur; Özkurt, Sibel; Mutlu, Levent Cem; Yaşar, Zehra; Eşme, Hıdır; Erol, Mehmet Muharrem; Oruç, Özlem; Erdoğan, Yurdanur; Aşker, Selvi; Ulaş, Arife; Erol, Serhat; Kerget, Buğra; Erbaycu, Ahmet Emin; Teke, Turgut; Besiroglu, Mehmet; Can, Hüseyin; Dallı, Ayşe; Talay, Fahrettin

doi:10.5578/tt.67689

Cited by 14 publications

(11 citation statements)

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“…Patients with moderate to severe severity pain, dyspnea, and anxiety were independently related to insomnia. 23 Taken together, this information is consistent with data of the that sleep deprivation, fragmentation and hypoxia negatively predict survival shining light on the role of sleep on the innate and adaptive immune systems. [24][25][26] The study has some limitations due to the nature of a crosssectional design.…”

Section: Discussionsupporting

confidence: 82%

Insomnia in patients with advanced lung cancer admitted to palliative care services

Mercadante

Valle²,

Cartoni

et al. 2021

Int J Clin Pract

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Insomnia has been reported to be more frequent in cancer patients than in general population, with a variable prevalence ranging from 24% to 95%, [3][4][5][6] suggesting that sleep disturbances develop in a substantial proportion of cancer patients. Of interest, sleep quality was found to be highly correlated with survival. 7 Although insomnia is common and may have a negative impact on quality of life, it has received little attention, differently from other symptoms cancer-related. 8 As few papers have assessed this subject, more information is needed to characterise insomnia in patients with advanced lung cancer.The aim of this study was to assess the prevalence of insomnia and the possible factors associated with insomnia in patients with advanced lung cancer admitted to palliative care services. | ME THODSThis is a secondary analysis of a study assessing insomnia in patients with advanced cancer in different palliative care settings. This large multicenter study was performed for a period of 6 months from January to June 2015 in six centers in Italy. Informed consent and ethical committee approval were obtained. Inclusion criteria were:A diagnosis of lung cancer, and ability to provide the information requested.

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Section: Discussionsupporting

confidence: 82%

Insomnia in patients with advanced lung cancer admitted to palliative care services

Mercadante

Valle²,

Cartoni

et al. 2021

Int J Clin Pract

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“…As reported in previous studies, sleep disturbance was focused on patients with breast cancer, and the incidence of sleep problems ranged from 39.5 to 69% (19,23). However, other studies showed that patients with lung cancer had the poorest sleep quality compared with other cancer types or control populations (24,25). A similar result was found in the cureent study that patients with lung cancer had the highest proportion of sleep disorders (45.2%) before radiotherapy compared with other cancer types.…”

Section: Discussionmentioning

confidence: 93%

“…Most studies focused on sleep problems in patients with cancer, and the probabilities of sleep disturbance in different tumor subtypes showed significant discrepancies (19,(23)(24)(25)(26). As reported in previous studies, sleep disturbance was focused on patients with breast cancer, and the incidence of sleep problems ranged from 39.5 to 69% (19,23).…”

Section: Discussionmentioning

confidence: 96%

Evaluation of Subjective Sleep Disturbances in Cancer Patients: A Cross-Sectional Study in a Radiotherapy Department

et al. 2021

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Background: The factors associated with sleep disturbances in cancer patients remains unclear. This study aimed to explore the prevalence of sleep disorders and predictors associated with sleep disturbance in cancer patients from a radiotherapy department.Methods: Patients with cancers were recruited before the start of radiotherapy from our institution between January 2019 and February 2020. Pittsburgh Sleep Quality Index (PSQI) scale was used to assess sleep quality. Descriptive statistics, Chi-square test, and multivariate logistic regression analysis were used to conduct statistical analysis.Results: A total of 330 eligible patients were included. Of them, 38.3% (n = 127) had the globe PSQI score >7, indicating that they suffered from sleep disorders. Patients with lung cancer (45.2%) were more likely to suffer from sleep disturbance, followed by cervical cancer (43.8%), nasopharyngeal carcinoma (41.7%), esophageal cancer (41.5%), breast cancer (37.7%), and colorectal cancer (30%). With regard to the PSQI components, the mean sleep duration was 8 h, 20.3% (n = 67) of them reported poor subjective sleep quality, 6.1% (n = 20) needed medication to improve sleep, and 53.6% (n = 177) suffered daytime dysfunction. Multivariate logistic regression models showed body mass index (BMI) ≥ 20 kg/m2 [odds ratio (OR) 0.599, 95% confidence interval (CI) 0.329–0.948, P = 0.031] and the receipt of surgery (OR 0.507, 95% CI 0.258–0.996, P = 0.048) were the significant favorable predictors for sleep disturbance, while age, gender, marital status, education level, comorbidity, metastasis status, diagnostic status, and cancer type were not significantly associated with sleep disturbance.Conclusions: Approximately 40% of the cancer patients suffer from sleep disturbance before the start of radiotherapy. Patients with BMI ≥ 20 kg/m2 and receiving surgery are less likely to develop sleep disturbance in comparison with others.

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“…Moreover, Nishiura et al found a prevalence of 56% in lung cancer patients who were admitted to hospital or already in-patients, regardless of the type of treatment (14). In addition, Bülbül et al reported rates of 48.4% for difficulty initiating or maintaining sleep (DIMS) and of 44.7% for insomnia in a large unspecified cohort of 1,245 patients with lung cancer (15).…”

Section: Discussionmentioning

confidence: 99%

Sleep Disturbances in Lung Cancer Patients Assigned to Definitive or Adjuvant Irradiation

Rades

Kopelke

Tvilsted

et al. 2021

In Vivo

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Background/Aim: A considerable number of patients with lung cancer are scheduled for definitive or adjuvant radiotherapy. Prevalence and potential risk factors of preradiotherapy sleep disturbances were evaluated. Patients and Methods: Nineteen factors were retrospectively investigated for associations with pre-radiotherapy sleep disturbances in 77 lung cancer patients. Factors included COVID-19 pandemic; age; gender; performance score; comorbidity index; history of another malignancy; distress score; number of emotional, physical or practical problems; patient's request for psychological support; histology; tumor stage; upfront surgery; chemotherapy; and type of radiotherapy. Results: Thirty-one patients (40.3%) reported sleep disturbances that were significantly associated with distress score 6-10 (p=0.019), ≥2 emotional problems (p=0.001), ≥5 physical problems (p<0.001), and request for psychological support (p=0.006). Trends were found for female gender (p=0.064) and stereotactic body radiation therapy (p=0.057). Conclusion: Many lung cancer patients assigned to radiotherapy reported sleep disturbances. Risk factors can be used to identify patients in need of psychological support already before treatment.Lung cancer is the second most common type of cancer in the Western countries (1). For patients with advanced non-small cell lung cancer (NSCLC), definitive radiotherapy is indicated for unresectable stage III disease and selected patients with stage IV disease (2). Also, patients who cannot undergo thoracic surgery due to advanced age, poor performance status or high comorbidity index can be treated with definitive radiotherapy. Moreover, after microscopically or macroscopically incomplete resection, patients may receive adjuvant radiotherapy. Radiotherapy is often combined with sequential and/or concurrent cisplatin-based chemotherapy (2). Moreover, patients with tumors ≤4 cm without lymph node metastasis who are not candidates for surgery can be treated with stereotactic body radiation therapy (SBRT) using higher doses per fraction than for conventionally fractionated radiotherapy (2, 3).The majority of patients with small cell lung cancer (SCLC) receive definitive radiotherapy, which is generally combined with sequential and/or concurrent chemotherapy. The standard chemotherapy regimen includes cisplatin and etoposide (2).Radiotherapy for lung cancer can be associated with serious side effects. Potential acute toxicities include dermatitis, pneumonitis, esophagitis, cardiac arrhythmia, hypothyroidism, loss of appetite, nausea and vomiting, fatigue and pancytopenia (4-6). The possibility of these adverse events and being assigned to a treatment using hightechnology and radiation can cause significant emotional distress for the patients associated with sleep disturbances. Studies focusing on sleep disturbances in patients irradiated for lung cancer are rare. The present study aimed to provide additional data for this stressful situation. One major aim was the determination of the prevalence of sleep distur...

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Sleep disturbances in patients with lung cancer in Turkey

Abstract: Sonuç: Çalışmamız, kanser semptomları ile uyku kalitesi arasında yakın bir ilişki olduğunu ortaya koymuştur. Bu nedenle, akciğer kanserli hastalarda kaliteli bir uyku için, kanser semptomların yeterince kontrol edilmesi gereklidir.

Cited by 14 publications

References 14 publications

Insomnia in patients with advanced lung cancer admitted to palliative care services

Insomnia in patients with advanced lung cancer admitted to palliative care services

Evaluation of Subjective Sleep Disturbances in Cancer Patients: A Cross-Sectional Study in a Radiotherapy Department

Sleep Disturbances in Lung Cancer Patients Assigned to Definitive or Adjuvant Irradiation

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