Sleep disturbances in ‘migraine without aura’ — A questionnaire based study

Karthik, Naveen; Kulkarni, Girish Baburao; Taly, Arun B.; Rao, Shivaji; Sinha, Sanjib

doi:10.1016/j.jns.2012.07.057

Cited by 39 publications

(48 citation statements)

References 16 publications

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“…Additionally, our study revealed that migraineurs’ sleep disturbances are attributed to “go to sleep within 30 minutes,” “wake up in the middle of the night or early morning,” and “bad dreams.” Consistent with our findings, Karthik et al found a high prevalence of poor sleepers among patients with “migraine without aura,” who reported difficulty in sleep initiation, sleep maintenance, and early morning waking. 9 Furthermore, our subgroup of migraine with aura also had similar findings.…”

Section: Discussionsupporting

confidence: 76%

Associations Between Sleep Quality and Migraine Frequency

Lin

Lee

et al. 2016

Medicine

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Migraine has been associated with sleep disturbances. Relationship between sleep quality and migraine frequency is yet to be determined. The present study aimed to investigate sleep disturbances among low-frequency, moderate-frequency, high-frequency, and chronic migraineurs, with and without auras, with well-controlled confounding variables.This cross-sectional controlled study included 357 subjects from an outpatient headache clinic in Taiwan. Standardized questionnaires were utilized to collect demographic, migraine, sleep, depression, anxiety, and restless leg syndrome characteristics in all participants. According to frequency of migraine attacks, patients were divided into 4 groups: with 1 to 4 migraine days per month, 5 to 8 migraine days in a month, 9 to 14 migraine days in a month, and >14 migraine days per month. The Pittsburgh Sleep Quality Index (PSQI) and subgroup items were used to evaluate sleep quality. The association between migraine frequency and sleep quality was investigated using multivariable linear regression and logistic regression.The PSQI total score was highest in patients with high frequent migraine (10.0 ± 3.4) and lowest in controls (7.0 ± 3.4) with a significant trend analysis (P for trend = 0.006). Migraine frequency had an independent effect on the items “Cannot get to sleep within 30 minutes” (P < 0.001), “Wake up in the middle of the night or early morning” (P < 0.001), “Bad dreams” (P = 0.001), “Pain” (P = 0.004), and “Quality of sleep” (P < 0.001). The result showed the effect of migraine frequency in both the aura-present (P for trend = 0.008) and the aura-absent subgroups (P for trend = 0.011).High migraine frequency correlates with poor sleep quality and a higher prevalence of poor sleepers. These associations occur in migraine with aura and without aura.

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Section: Discussionsupporting

confidence: 76%

Associations Between Sleep Quality and Migraine Frequency

Lin

Lee

et al. 2016

Medicine

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“…Studies point to a U-shaped association between sleep duration and coronary heart disease and stroke [30]. The prevalence of sleep abnormalities has been reported as being much higher in migraineurs as compared with controls [51,52]. In our study, even though no between-group differences in sleep quality were found, we detected shorter sleep duration in migraineurs compared to controls, regardless of nutritional status.…”

Section: Discussioncontrasting

confidence: 60%

Cardiovascular disease risk in women with migraine

et al. 2013

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BackgroundStudies suggest a higher prevalence of unfavourable cardiovascular risk factors amongst migraineurs, but results have been conflicting. The aim of this study was to investigate traditional and newly recognized risk factors as well as other surrogate markers of cardiovascular risk in obese and normal weight women with migraine.MethodsFifty-nine adult female probands participated in this case–control study. The sample was divided into normal weight and obese migraineurs and age- and body mass index-matched control groups. The following cardiovascular risk factors were analyzed: serum levels of lipids, fasting glucose, and insulin; insulin resistance; blood pressure; smoking (categorized as current, past or never); Framingham 10-year risk of general cardiovascular disease score; C-reactive protein; family history of cardiovascular disease; physical activity; sleep disturbances; depression; and bioelectrical impedance phase angle. The means of continuous variables were compared using Student’s t-test for independent samples or the Mann–Whitney U-test (for 2 groups) and ANOVA or the Kruskal-Wallis test (for 4 groups) depending on the distribution of data.ResultsAll migraineurs were sedentary irrespective of nutritional status. Migraineurs had higher depression scores and shorter sleep duration, and obese migraineurs, in particular, had worse sleep quality scores. Insulin resistance and insulinaemia were associated with obesity, and obese migraineurs had lower HDL-c than normal weight controls and migraineurs. Also, the Framingham risk score was higher in obese migraineurs.ConclusionThese findings suggest that female migraineurs experience marked inactivity, depression, and some sleep disturbance, that higher insulin resistance and insulinaemia are related to obesity, and that obesity and migraine probably exert overlapping effects on HDL-c levels and Framingham 10-year cardiovascular risk.

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“…Barbanti et al reported similar findings (20% vs 6%) and higher prevalence in those with medication overuse . Prevalence of excessive daytime sleepiness using the Epworth Sleepiness Scale (ESS) ranges from 14% to 37% …”

Section: Expert Opinionmentioning

confidence: 80%

“…Compared with healthy controls, 60 patients (66.7%) had a poor sleep quality compared with 7 controls (7.8%). 48 Seidel et al investigated 489 subjects with migraines and found that the quality of sleep was decreased in patients with migraine, but fatigue and daytime sleepiness was not different from healthy controls. The decreased quality of sleep was not due exclusively to depression or anxiety.…”

mentioning

confidence: 99%