Sleep Disturbances in Essential Tremor and Parkinson Disease: A Polysomnographic Study

Barut, Banu Özen; Taşçılar, Nida; Varo, Armagan

doi:10.5664/jcsm.4778

Cited by 32 publications

(22 citation statements)

References 28 publications

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“…In only one study were no significant differences in ET evident: the number of subjects with an ESS ≥10 was 48% in 60 PD cases, 13% in 93 ET cases and 11% in 296 controls [29]. In a polysomnographic study of 16 ET cases, 21 PD cases and 14 controls [5], for many of the results, ET cases had values that were intermediate between PD and controls (e.g., percent time spent in rapid eye movement sleep, total arousal index, etc). Interestingly, one study, a prospective, population-based study of individuals ≥65 years of age, evaluated the relationship between daily sleep duration at baseline (i.e., the sum of nighttime sleep and daytime napping) and the risk of incident ET [30].…”

Section: Resultsmentioning

confidence: 99%

“…Numerous controlled studies now document their presence above and beyond what is observed in comparison with normal age-matched controls; that is, they seem to be disease-associated rather than age-associated. These features fall into several distinct clinical domains: cognitive [3], psychiatric [2], sensory [4] and other (e.g., sleep disturbance [5]).…”

Section: Discussionmentioning

confidence: 99%

“…These may be classified into several distinct domains: cognitive [3], psychiatric [2], sensory [4] and other (sleep disturbance [5]). The presence of such features should come as no surprise, as non-motor features commonly accompany and seem to be a clear phenotype that coexists alongside the motor features of a wide range of other disorders of involuntary movement [6].…”

Section: Introductionmentioning

confidence: 99%

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Non-motor symptoms in essential tremor: A review of the current data and state of the field

Louis

2016

Parkinsonism & Related Disorders

122

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Background The motor features of essential tremor (ET) include its hallmark element, kinetic tremor, yet non-motor features are increasingly being recognized as an accompanying part of what was previously viewed as a solely motor disorder. Given the evolving state of the ET field with respect to these non-motor features, the purpose of this manuscript is to critically review the current data. Methods A PubMed search was conducted on July 1, 2015. The term “essential tremor” was crossed in sequential order with 13 additional search terms (e.g., “cognitive”, “dementia”, “depression”). The total number of unique hits was 322. Results Numerous studies seem to substantiate the presence of a range of non-motor features occurring in excess in ET cases compared to age-matched controls. These comprise cognitive features (including a full spectrum from mild cognitive difficulty through to frank dementia), psychiatric (including depression, apathy, anxiety, and personality characteristics), sensory (hearing and possibly olfactory abnormalities), and other non-motor features (e.g., sleep dysregulation). Emerging evidence suggests that some of these features could be primary disease features that pre-date motor features of ET. Conclusions The presence of numerous non-motor features in ET is increasingly evident. The biological basis of these features deserves additional study.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Non-motor symptoms in essential tremor: A review of the current data and state of the field

Louis

2016

Parkinsonism & Related Disorders

122

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“…(3) The spectrum of NMS in ET includes cognitive, psychiatric, sensory and other disorders (sleep disturbances, decreased body mass index, decreased quality of life). (3)(4)(5)(6)(7)(8)(9)(10)(11) NMS in ET, along with obligate symptoms, make up a common, rather complex phenotype of the disease. (12) A number of authors do not exclude the probability of a manifestation of the disease with NMS.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Non-Motor Symptoms in Essential Tremor

Govorova¹,

Попова²,

Tappakhov³

et al. 2019

IJBM

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In the clinical picture of essential tremor (ET), in addition to tremulous hyperkinesis, the importance of non-motor manifestations has recently been discussed. Despite their high occurrence, in most cases these manifestations remain unverified. The purpose of this study was to assess the incidence of non-motor symptoms (NMS) in patients with ET. The study included 3 groups comparable by sex and age. Group 1 (the main group) consisted of 53 patients with ET; Group 2 consisted of 57 patients with Parkinson's disease (PD); Group 3 consisted of 111 individuals without ET or PD, and without burdened heredity for extrapyramidal diseases. In study Groups the distribution by ethnicity was as follows: 22(41.5%) ethnic Yakuts and 31(58.5%) ethnic Russians in Group 1, 29(50.9%) ethnic Yakuts and 28(49.1%) ethnic Russians in Group 2, and 67(60.4%) ethnic Yakuts and 44(39.6%) ethnic Russians in Group 3. All subjects filled out the NMSQuest scale, which contains 30 questions for various groups of NMS. The analysis of NMS using the NMSQues scale in the three study groups showed a similarity between ET plus and PD in non-motor manifestations. The spectrum of NMS in patients with ET plus of both ethnic groups is heterogeneous and prevails in patients of the Russian ethnic group. Thus, Yakut patients with ET plus and PD showed a similarity in the frequency of hyposmia to Russian representatives with ET plus and PD in hyposmia, dysphagia, pain, sadness and restless legs syndrome. Excessive sweating was found in more than 64% of patients with ET plus of both ethnic groups. The results indicate a similarity in manifestations of ET plus and PD, which is possibly due to both the genetic and phenotypic affinity of these nosologies, and suggests that ET plus can be a transitional form of PD. (International Journal of Biomedicine. 2019;9(4):308-312.)

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“…In addition to tremors, individuals with ET may have other motor and non-motor symptoms (3) including poorer balance (4, 5), cognitive impairment (6, 7), depression (8), and sleep dysregulation (9). …”

Section: Introductionmentioning

confidence: 99%

Perceived embarrassment and caregiver burden in essential tremor caregivers

Kellner

Morgan

Gutierrez

et al. 2017

Journal of the Neurological Sciences

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Essential tremor (ET) is a progressive neurological disease associated with functional disability, diminished quality of life and, in some individuals, poorer balance, cognitive impairment, depression and sleep dysregulation. Individuals with ET may rely on family members and friends to act as informal caregivers to assist with daily activities and provide emotional support. There is a high prevalence of embarrassment among individuals with ET, which may be a result of the outwardly visible nature of tremor. Studies in populations with outwardly visible disability have shown that perception by caregivers of a care-recipient’s social distress can contribute to caregiver burden. We hypothesize that in ET, perception by caregivers of ET participant embarrassment is a predictor for caregiver burden. Data were collected from 57 ET participants and their caregivers. We measured ET participant embarrassment using the Essential Tremor Embarrassment Assessment (ETEA), and measured perception by caregivers of ET participant embarrassment using a modified version of the ETEA. The Zarit Burden Interview was used to measure caregiver burden. Perceived embarrassment was associated with ET participant embarrassment. In linear regression models, perceived embarrassment was a stronger predictor for caregiver burden than measures of ET participant cognitive and physical impairment. The results indicate that perception of ET participant embarrassment can be burdensome for caregivers. Clinicians may wish to address patient embarrassment and perceived embarrassment to better support caregivers and ET patients.

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Sleep Disturbances in Essential Tremor and Parkinson Disease: A Polysomnographic Study

Cited by 32 publications

References 28 publications

Non-motor symptoms in essential tremor: A review of the current data and state of the field

Non-motor symptoms in essential tremor: A review of the current data and state of the field

Assessment of Non-Motor Symptoms in Essential Tremor

Perceived embarrassment and caregiver burden in essential tremor caregivers

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