Sleep disturbances are underappreciated in prostate cancer survivorship

Gong, Fred; Loeb, Stacy; Siu, Katherine; Myrie, Akya; Orstad, Stephanie L.; Kenfield, Stacey A.; Morgans, Alicia K.; Thakker, Sameer; Robbins, Rebecca; Carter, Patricia; Jean‐Louis, Girardin; Nolasco, Tatiana Sanchez; Byrne, Nataliya; Gupta, Natasha

doi:10.1038/s41391-022-00630-6

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…Sleep disturbance is prevalent among prostate cancer survivors, with 50% reporting poor sleep quality [25]. Furthermore, hot ashes are a major contributor to increased sleep disturbance in individuals undergoing ADT [12,25,26]. Participants in the current study reported moderate hot ash interference with sleep at baseline in the HFRDIS, while 70% reported being bothered by hot ashes and night sweats during the nighttime or while asleep.…”

Section: Discussionmentioning

confidence: 79%

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Feasibility of a novel wearable thermal device for management of bothersome hot flashes in patients with prostate cancer

Peeke,

Billes,

Vetter

et al. 2023

Preprint

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BACKGROUND This single-arm prospective study evaluated the feasibility of a novel wrist-worn thermal device that applies cooling to the inside of the wrist for management of bothersome hot flashes in prostate cancer survivors. METHODS 57 individuals were enrolled and instructed to use the device as needed for 4 weeks. The primary outcome was thermal device usage (hours and sessions per day). Additional outcomes included the change in patient reported Hot Flash Related Daily Interference Scale (HFRDIS, range 0–10) and Patient Reported Outcomes Measurement Information System Sleep Disturbance 4a (PROMIS SD T-score, range 0-100) and Sleep Related Impairment 8a (PROMIS SRI T-score, range 0-100). Study procedures were conducted remotely from May to Dec 2021 in the US. RESULTS 44 participants completed the study and 39 had retrievable usage data. The mean ± SD age was 67 ± 6 years and 5 ± 5 years since cancer diagnosis. Baseline scores indicated moderate hot flash interference (HFRDIS mean ± SD: 4.3 ± 2.0) and mild sleep disturbance (PROMIS SD: 56.4 ± 6.7). Mean ± SD use of the thermal device was 3.2 ± 2.5 hours/day and 7.6 ± 3.6 sessions/day. Most (67%) participants reported using the device 7 days/nights each week. Statistically significant improvements from baseline at Week 4 were observed for HFRDIS (mean ± SE change: -1.1 ± 0.3), PROMIS SD (-6.0 ± 1.0), and PROMIS SRI (-5.5 ± 1.2) scores (all p < .001). Improvements were also observed in subjective measures of hot flashes and night sweats. The majority (69%) of participants reported that the thermal device was effective at helping them manage hot flashes. No adverse events were reported. CONCLUSIONS Results support the feasibility of using the thermal device for management of bothersome hot flashes in prostate cancer survivors. Future randomized controlled studies are warranted to evaluate patient reported outcomes related to frequency and severity of hot flashes, sleep quality, fatigue, and overall quality of life.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Feasibility of a novel wearable thermal device for management of bothersome hot flashes in patients with prostate cancer

Peeke,

Billes,

Vetter

et al. 2023

Preprint

Self Cite

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“…However, PCa patients are more prone to depression, anxiety, and insomnia [41,42] , possibly due to the effects of physical and psychological stress caused by the diagnosis and treatment of PCa, including pain sensations, sexual dysfunction, and depressed mood. Research on the correlation between PCa and ADHD is scarcer, perhaps because the primary prevalence groups of the two diseases range in age, and studies covering such a lengthy duration are very di cult to do.…”

Section: Discussionmentioning

confidence: 99%

Causal relationships between prostate cancer and six psychiatri c disorders: A two-sample Mendelian randomization study

wu,

Zhang,

Chen

et al. 2023

Preprint

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Background Prostate cancer (PCa) diagnosis and survival have increased significantly with the development and use of screening techniques. The PCa patient population has a higher risk of psychiatric health issues than the overall population. It has not been demonstrated that PCa and psychiatric disorders are related genetically. Methods The current investigation employed a two-sample bidirectional Mendelian randomization design, incorporating a genome-wide association study (GWAS) to systematically screen for genetic instrumental variables related to PCa and six psychiatric disorders, namely major depressive disorder, Alzheimer's disease, insomnia, bipolar disorder, anxiety disorders, and attention deficit hyperactivity disorder. The primary method for assessing causal associations between the two disorders was Inverse Variance Weighting (IVW), supplemented by additional analyses utilizing the MR-Egger and Weighted Median methods, as well as sensitivity analyses to confirm their dependability. In order to confirm the good outcomes of the MR study, we also chose another set of prostate cancer GWAS data from the same pedigree population. To make the results more reliable, we conducted a meta-analysis. Results Genetically predicted PCa was associated with higher odds of BD (OR = 1.06,95%, CI = 1.02–1.10, PIVW=0.0055) and lower odds of MDD (OR = 0.97,95% CI = 0.95-1.00, PIVW=0.0261) in the forward MR analysis from PCa to psychiatric disorders. Reverse MR analysis showed that genetically expected BD (OR = 1.08, 95% CI = 1.01–1.10, PIVW=0.0303) was associated with higher odds of PCa. No causal association was found between the other four psychiatric disorders and PCa in the two-way analysis. Heterogeneity and horizontal pleiotropy were not observed in all results, and the robustness of the results was demonstrated by the leave-one-out results. MR analyses performed with the optional additional PCa GWAS were directionally consistent with the main analysis, confirming a causal association between MDD and PCa, but greater heterogeneity was observed in the bidirectional causal association of BD. Conclusions Our research suggested a potential genetic causal relationship between BD, MDD, and PCa. There was no genetically based causal relationship found between PCa, ADHD, sleeplessness, anxiety disorders, and AD. The results of this study have significant ramifications for the future screening and management of PCa patients, particularly with regard to the inclusion of psychological therapies and support.

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“…In addition, it is the most serious complication of prostate cancer patients treated with androgen deprivation therapy ( 15 ). However, in clinical practice, comorbid sleep-wake disorders in cancer patients are often overlooked by clinicians and patients ( 16 ) and are associated with poor prognosis ( 7 , 14 , 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

Visual analysis of the research frontiers, hotspots and trends of exercise therapy intervention in tumor-related sleep-wake disorders

Han,

Zhang,

Zhang

et al. 2024

Front. Oncol.

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ObjectiveTo systematically understand the research frontiers, hotspots and development trends of exercise therapy in the intervention of tumor-related sleep-wake disorders, and to provide scientific basis for follow-up research.MethodsDownloaded the original research papers on February 26, 2024, from the Web of Science core collection database, on tumor-associated sleep-wake disorders. The data that met the inclusion criteria were imported into the Bibliometric Analysis Platform (http://biblimetric.com), CiteSpace 6.3.R1 and VOSviwer1.6.20 software for visual analysis, and imported into Excel2021. Scientometric analysis was performed with Oringin2021 and PyCharm Community Edition 2022.1.3.ResultsA total of 512 original research papers on tumor-related sleep-wake disorders were obtained. The most influential countries in the subject area are the United States, Spain and German, the institutions are the University of California System, Sun Yat Sen University and Northwestern University, et al., the authors are Berger AM, Aaronson NK, Bower JE, et al., and the journals are Cancer, Brit J Cancer and Cancer Nurs. The co-cited references suggest that the current research frontier in the field mainly involves the level, place and program of exercise therapy, including the relationship between physical activity, sedentary behavior and cancer prevention and control. The results of co-occurrence keyword network analysis showed that quality of life, physical activity, breast cancer, exercise, fatigue, and survivors may be the research hotspots in this field, with breast cancer, health, aerobic exercise, adults, and chemotherapy being the most popular.ConclusionsThe number of papers published and the research enthusiasm in this field show a steady upward trend. However, there is a lack of influential institutions and scholars, and there is relatively little research collaboration across countries/regions/institutions. The scientific research influence of institutions and scholars in most European and American countries/regions is significantly ahead of that of institutions and scholars in Asian and African countries/regions. But Sun Yat Sen University in China is a relatively active and influential scientific research institution in recent years, which is worthy of attention. In addition, the research frontier of this discipline is the level, place and program of exercise therapy auxiliary intervention, and the research hotspots involve breast cancer, health, aerobic exercise, adults, chemotherapy, et al. Their clinical efficacy needs to be further demonstrated in multi-center, large-sample and high-quality prospective studies.

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Sleep disturbances are underappreciated in prostate cancer survivorship

Cited by 5 publications

References 8 publications

Feasibility of a novel wearable thermal device for management of bothersome hot flashes in patients with prostate cancer

Feasibility of a novel wearable thermal device for management of bothersome hot flashes in patients with prostate cancer

Causal relationships between prostate cancer and six psychiatri c disorders: A two-sample Mendelian randomization study

Visual analysis of the research frontiers, hotspots and trends of exercise therapy intervention in tumor-related sleep-wake disorders

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