Sleep Disturbances Among Soldiers With Combat-Related Traumatic Brain Injury

Collen, Jacob; Orr, Nicholas; Lettieri, Christopher J.; Carter, Kevin; Holley, Aaron B.

doi:10.1378/chest.11-1603

Cited by 120 publications

(83 citation statements)

References 49 publications

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“…Subjective complaints of sleep-wake disturbances occur in 30-70% of those with TBI of all severity [76][77][78][79][80]. Insomnia, fatigue, and somnolence are the most common clinical diagnoses reported following mTBI, but sleep-disordered breathing can also develop.…”

Section: What Sleep Disorders Occur Following Mtbi?mentioning

confidence: 99%

“…Indeed, subjective complaints of daytime sleepiness are reported in 50-85% of individuals following head injuries [76,77]. Both blast and blunt trauma head injuries can damage essential neural wakefulness circuits, including orexin-(hypocretin) producing cells in the hypothalamus leading to a centrally mediated hypersomnia [86].…”

Section: Hypersomnolencementioning

confidence: 99%

“…Studies have reported OSA in 35-61% of patients with TBI [44,76]. In addition, patients with TBI with comorbid OSA experience greater neurocognitive impairments in memory and attention than those with similar TBI severity who do not have OSA [91].…”

Section: Hypersomnolencementioning

confidence: 99%

“…Insomnia is the most common sleep disorder following TBI of all severities, occurs in 30-65% of those with chronic symptoms, and is more common with less severe and blast-related injuries [39,76,96]. Similar to hypersomnia, insomnia associated with mTBI is frequently confounded by other factors, particularly pain and comorbid psychiatric disorders.…”

Section: Insomnia and Circadian Dysregulationmentioning

confidence: 99%

See 3 more Smart Citations

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.

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Section: What Sleep Disorders Occur Following Mtbi?mentioning

confidence: 99%

Section: Hypersomnolencementioning

confidence: 99%

Section: Hypersomnolencementioning

confidence: 99%

Section: Insomnia and Circadian Dysregulationmentioning

confidence: 99%

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Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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“…The tight link between brain trauma and sleep abnormalities is supported by the observation that intracranial bleed and wide speared brain injury are both associated with increase sleep need (10). In a military setting, blunt head injury was found as a risk factor for OSA in a cohort of mild -moderate TBI (11).…”

Section: Neuroanatomical Correlationsmentioning

confidence: 98%

Sleep and Sleep Impairment in Victims of Traumatic Brain Injury

Gadoth

2018

Middle East J Rehabil Health Stud

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Context: Sleep impairment after Traumatic Brain Injury (TBI) is a common consequence of the injury and frequently complicates recovery. To review in brief the current knowledge in regard to sleep impairment following traumatic brain injury. Evidence Acquisition: The relevant literature was reviewed. Results: Practical issues in regard to epidemiology, clinical presentation, medical workup, as well as pathophysiology and treatment modes were addressed. Conclusion: As the spectrum of civil head and brain trauma is quickly expanding, it is important to increase our knowledge of sleep impairment characteristics in victims of TBI and look for more efficient treatment modes for those impairments than those used today.

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Associations between residual hyperarousal and insomnia symptoms in veterans following a 2‐week intensive outpatient program for posttraumatic stress disorder

Tanev

Lynch

Blackburn

et al. 2021

Journal of Traumatic Stress

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Many returning military service members and veterans who were deployed following the September 11, 2001, terrorist attacks (9/11) suffer from posttraumatic stress disorder (PTSD) and insomnia. Although intensive treatment programs for PTSD have shown promise in the treatment of PTSD symptoms, recent research has demonstrated that sleep disturbance shows little improvement following intensive trauma-focused treatment. The aim of the present study was to evaluate changes in self-reported insomnia symptoms among veterans and service members following participation in a 2-week intensive program for PTSD. We further aimed to investigate if residual PTSD symptoms, specifically hyperarousal, were associated with residual insomnia symptoms. Participants (N = 326) completed self-report assessments of insomnia, PTSD symptoms, and depressive symptoms at pre-and posttreatment. At pretreatment, 73.9% of participants (n = 241) met the criteria for moderate or severe insomnia, whereas at posttreatment 67.7% of participants (n = 203) met the criteria. Results of paired t tests demonstrated statistically significant differences between pre-and posttreatment Insomnia Severity Index scores; however, the effect size was small, d = 0.34. Analyses revealed that posttreatment hyperarousal symptoms were associated with posttreatment insomnia. These findings suggest that although an intensive program for service members and veterans with PTSD may significantly reduce insomnia symptoms, clinically meaningful residual insomnia symptoms remain. Further research is warranted to elucidate the association between residual hyperarousal and insomnia symptoms following intensive trauma-focused treatment.

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Sleep Disturbances Among Soldiers With Combat-Related Traumatic Brain Injury

Cited by 120 publications

References 49 publications

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Sleep and Sleep Impairment in Victims of Traumatic Brain Injury

Associations between residual hyperarousal and insomnia symptoms in veterans following a 2‐week intensive outpatient program for posttraumatic stress disorder

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