Sleep disturbance is associated with mild cognitive impairment: a community population-based cross-sectional study

Abstract

Background Sleep is conducive to the elimination of brain metabolites and the recovery of brain function. However, the relationship between sleep disturbance and Mild Cognitive Impairment is not fully been determined. Methods This was a community population-based cross-sectional study. A total of 1,443 participants from a village in the suburbs of Xi’an, China were enrolled in 2017. Sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI), and sleep disturbance was defined as a PSQI score > 5. Mini-Mental State Examination (MMSE) was used to assess cognitive function and Mild Cognitive Impairment(MCI) was defined as the MMSE score less than cutoff values and meets the diagnostic criteria. Univariate and multivariate analyses were used to analyze the relationships between sleep disturbance and MCI. Results Among 1,443 subjects, 69(4.78%) had MCI, and 830 (57.52%) had sleep disturbance. In bivariate analysis, MCI was associated with sleep disturbance (ρ = 0.094, P<0.001). In the binary logistic regression, MCI was positively associated with the sleep disturbance (OR = 2.027, 95%CI = 1.112–3.698, P = 0.021). In the internal constitution of PSQI, MCI was negatively associated with the habitual sleep efficiency (OR = 0.447, 95%CI = 0.299–0.669, P < 0.001). Compared with waking up before or at 7 am, waking up after 7 am (OR = 0.555, 95%CI = 0.309–0.995, P = 0.048), or 8 am (OR = 0.296, 95%CI = 0.097–0.902, P = 0.032) was probably more likely to have normal cognition. However, people who slept more than 8 h a day might be more likely to suffer from MCI (OR = 5.560, 95%CI = 1.419–21.789, P = 0.014). Conclusion Sleep disturbance is associated with Mild Cognitive Impairment. However, the causal relationship between them is not clear. It needs to be further studied.

Respiratory Dysfunction in Alzheimer’s Disease—Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions

“…There appears to be a synergistic relationship between sleepdisordered breathing and Alzheimer's disease because they share certain etiological and physiopathological determinants that predispose them to the development of both disorders in the same patient (Figure 2) [34,82]. First, the presence of OSA, sleep fragmentation, and nocturnal hypoxia are linked with higher cognitive impairments such as decreased memory, attention, and executive function [83][84][85][86], symptoms inherent in AD. Furthermore, it was found that the more severe the form of OSA, the stronger the association between the apnea-hypopnea index, the oxygen desaturation index, and the prediction of memory impairment [87].…”

Recent advances in understanding of sleep disorders and disturbances for dementia risk and prevention

“…Prior work has shown that self-reported sleep quality is associated with cognitive decline, in particular executive function [20]. Three recent cross-sectional studies have also linked poor sleep quality to various neurological outcomes, including lower global cognition scores [21], lower cerebrospinal fluid (CSF) Aβ42 levels [21], higher CSF total tau levels [21], higher likelihood of having MCI [22], and more subjective cognitive complaints [23]. An analysis of 1168 older adults without dementia within the EPAD dataset found that self-reported poor sleep quality was linked to higher levels of CSF t-tau [24 ▪▪ ], cross-sectionally.…”

Music Intervention for older adults: Evidence Map of Systematic Reviews

“…[9] In fact, research has shown that listening to and playing music can change brain functions, improving cognitive functions such as memory [10] and attention, [11] as well as behavioral symptoms of older adults. [12] Long-term music training and learning of related skills can even stimulate the brain development of older adults. [13] Music intervention has also been shown to alleviate negative emotions such as anxiety [14] and depression, [15] and activate the subcortical circuit, limbic system, and emotional reward system, thereby stimulating well-being and improving the quality of life.…”