Sleep disturbance in chronic fatigue syndrome

Krupp, Lauren; Jandorf, Lina; Coyle, P. K.; Mendelson, Wallace B.

doi:10.1016/0022-3999(93)90134-2

Cited by 125 publications

(67 citation statements)

References 10 publications

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“…Prior to the revision of the diagnostic criteria for CFS/ME in 1994, two studies reported that over half of their CFS/ME patients had a sleep disorder as assessed by overnight polysomnography (PSG). 5,18 These sleep disorders include hypersomnia, sleep maintenance and sleep initiation insomnia, OSA, narcolepsy, and periodic limb movement disorder, as well as inadequate sleep hygiene. CFS/ME patients were found to have higher levels of fatigue and sleep disturbance than patients with multiple sclerosis 5 ; those with a comorbid sleep disorder reported greater functional impairment.…”

Section: Differential Diagnosesmentioning

confidence: 99%

“…5,18 These sleep disorders include hypersomnia, sleep maintenance and sleep initiation insomnia, OSA, narcolepsy, and periodic limb movement disorder, as well as inadequate sleep hygiene. CFS/ME patients were found to have higher levels of fatigue and sleep disturbance than patients with multiple sclerosis 5 ; those with a comorbid sleep disorder reported greater functional impairment. 18 Since these studies included CFS/ME patients with a suspected sleep disorder who were attending the sleep clinic, rather than randomly selected or consecutive patients, these figures are mostly likely inflated.…”

Section: Differential Diagnosesmentioning

confidence: 99%

“…Of direct relevance to the current review, patients often report daytime sleepiness, feeling unrefreshed upon waking despite suffi cient or extended total sleep time, extended sleep including daytime napping, and other sleep-related symptoms, such as diffi culty falling asleep and disturbed sleep. 2,4,5 Since the late 1980s, research in the area of CFS/ME has begun to focus on examining and determining the cause of non-restorative sleep and sleep disturbance in CFS/ME, and how these symptoms may relate or contribute to patients' daytime fatigue. The current review aims to provide a comprehensive overview of these studies, describe where the fi eld currently stands on this issue, and outline potential directions for future research.…”

Section: Introductionmentioning

confidence: 99%

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Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Jackson

Bruck

2012

Journal of Clinical Sleep Medicine

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Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ ME) is a chronic, disabling illness that affects approximately 0.2% of the population. Non-restorative sleep despite sufficient or extended total sleep time is one of the major clinical diagnostic criteria; however, the underlying cause of this symptom is unknown. This review aims to provide a comprehensive overview of the literature examining sleep in CFS/ ME and the issues surrounding the current research fi ndings. Polysomnographic and other objective measures of sleep have observed few differences in sleep parameters between CFS/ME patients and healthy controls, although some discrepancies do exist. This lack of signifi cant objective differences contrasts with the common subjective complaints of disturbed and unrefreshed sleep by CFS/ME patients. The emergence of new, more sensitive techniques that examine the microstructure of sleep are showing promise for detecting differences in sleep between patients and healthy individuals. There is preliminary evidence that alterations in sleep stage transitions and sleep instability, and other physiological mechanisms, such as heart rate variability and altered cortisol profi les, may be evident. Future research investigating the etiology of non-restorative sleep in CFS/ME may also help us to undercover the causes of non-restorative sleep and fatigue in other medical conditions. keywords: Chronic fatigue syndrome, myalgic encephalomyelitis, sleep, non-restorative sleep, sleep disorders, fatigue, sleepiness Citation: Jackson ML; Bruck D. Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review.

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Section: Differential Diagnosesmentioning

confidence: 99%

Section: Differential Diagnosesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Jackson

Bruck

2012

Journal of Clinical Sleep Medicine

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“…Also, there is no consensus as to the underlying pathophysiology of the disease [7,8]. Along with excessive daytime fatigue, symptoms of insomnia and insufficient, non-restorative sleep are among the most common and disabling complaints [4][5][6][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Although the results and procedures were varied; sleep efficiency was reduced in 7 of 7 studies [14,[16][17][18][19][20][21], time in bed was increased in 2 out of 2 studies [17,18] and wake after sleep onset was increased in 3 out of 3 studies [17,18,22]. Control subjects in these studies varied from patients with MDD to co-twin controls.…”

Section: Introductionmentioning

confidence: 99%

Aspects of Slow-Wave EEG Activity During Sleep in Twins Discordant for Chronic Fatigue Syndrome

Goldberg¹,

Watson²,

Buchwald³

et al. 2009

TOSLPJ

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Chronic Fatigue Syndrome (CFS) is a disease characterized by high levels of daytime fatigue. Complaints such as unrefreshing sleep and insomnia are common. Polygraphic studies of sleep in CFS patients have found evidence of disturbed sleep, but controls in these studies were often not adequate to evaluate differences specific to CFS. Watson, et al.[1] and Ball, et al.[2] used a co-twin control design to eliminate virtually all sources of confounding variance and found a small difference between levels of Stage 2 sleep (lower in CFS) and Stage 3 sleep (higher in CFS), where CFS ill twins showed a higher level of sleep complaint than the healthy twins which was not reflected in their sleep physiology. The current study will apply more sensitive measures of sleep EEG to these data to examine differences more closely. A cotwin control study was performed on 10 pairs of identical twins discordant for CFS. Data from the second sleep night were analyzed using fast-fourier analysis (FFT) and finally measures of slow-wave activity (SWA). Data for NREM periods was analyzed. There was a significant interaction in SWA for Twin x NREM period for the first 2 NREM periods with the healthy twins having more SWA in the first NREM period and less in the second NREM period. While overall SWA activity did not differentiate the groups, the distribution of SWA in the first 2 NREM periods could be associated with the experience of unrefreshing sleep. Typically, SWA in the first NREM period is associated with deep restorative sleep. Lower SWA in NREMP 1 in the ill CFS twins suggests that this process is compromised resulting in the experience of less refreshing sleep.

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A 56-Year-Old Woman With Chronic Fatigue Syndrome

Komaroff

1997

JAMA

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Sleep disturbance in chronic fatigue syndrome

Cited by 125 publications

References 10 publications

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Aspects of Slow-Wave EEG Activity During Sleep in Twins Discordant for Chronic Fatigue Syndrome

A 56-Year-Old Woman With Chronic Fatigue Syndrome

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