Sleep disorders in chronic pain and its neurochemical mechanisms: a narrative review

Abstract

Chronic pain (CP) is a prevalent problem, and more than half of patients with CP have sleep disorders. CP comorbidity with sleep disorders imposes immense suffering and seriously affects the patient’s quality of life, which is a challenging issue encountered by clinicians. Although the reciprocal interactions between pain and sleep have been studied to some degree, there is still a lack of awareness and comprehensive description of CP comorbidity with sleep disorders. In this narrative review article, we summarize the current knowledge about the present estimates of the prevalence of comorbid sleep disorders in CP patients, sleep detection methods, sleep characterization in CP, and the effect of sleep disorders on CP and current therapies. We also summarize current knowledge of the neurochemical mechanisms of CP comorbidity with sleep disorders. In conclusion, insufficient attention has been paid to the role of sleep disorders in CP patients, and CP patients should be screened for sleep disorders in the clinic. Special attention should be given to a possible risk of drug–drug interaction when using two types of drugs targeting pain and sleep simultaneously. The current insight into the neurobiological mechanisms underlying CP comorbidity with sleep disorders is still rather limited.

Physical therapy for survivors of torture: A scoping review

“…(Hoegh, 2022;Wijma et al, 2016) Poor sleep has a direct correlation with chronic pain symptoms, therefore identifying and addressing sleep issues is an important component of pain care. (Duo et al, 2023;Siengsukon et al, 2017) Self-efficacy is an individual's belief that they can carry out certain tasks or behaviors; low self-efficacy is correlated with disability, pain intensity, and is a (Ferrari et al, 2019;Raman & Sharma, 2022). Mental imagery has been used for treatment of complex regional pain syndrome, phantom pain, and other chronic pain conditions, and has been found to alter pain sensations.…”

Взаємозв’язок Між Способом Життя, Рівнем Стресу Та Хронічним Болем У Осіб Молодого Віку

“…У респондентів із високим рівнем фізичної активності спостерігався менший рівень суб'єктивного стресу (-0,76, p < 0.01). Сон і біль є важливими фізіологічними функціями, які взаємодіють одна з одною та впливають одна на одну в організмі людини [20]. Нами було виявлено значний зв'язок між порушенням сну у осіб молодого віку та інтенсивністю хронічного болю (0,63, p < 0.01).…”

Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain

“…Many studies, including ours, have shown that the use of single chemokine receptor antagonists (Scheme 1) can relieve pain of different etiologies, for example, the blockade of CCR1 (J113863) [7,8,17], CCR2 (RS504393) [6,187,188,220], CCR3 (SB328437) [7,21], CCR4 (C021) [28,64,65], CCR5 (maraviroc, AZD5672, TAK-220) [15,16,27,190], CXCR2 (NVP CXCR2 20, SB225002) [25,32,34,35,267,268,270], CXCR3 (NBI-74330, AMG487) [25,31,272], CXCR4 (AMD3100, AMD 3465) [43,273,274], and XCR1 (vMIP-II) [52,276]. It has been shown that some chemokines, e.g., CCL1 [5], CCL2 [12], CCL3 [17], CCL7 [12], CCL9 [17], and XCL1 [52], reduce the analgesic effect of opioids, and the use of neutralizing antibodies restores morphine and/or buprenorphine analgesia.…”

“…The cause can be a metabolic, neurodegenerative, vascular, or autoimmune disease; a tumor; trauma; infection; or exposure to toxins. Neuropathic pain evokes severe suffering, disability, depression, and sleep disturbances [3][4][5], and its therapeutic management is challenging [6]. Recommended analgesics provide poor or unsatisfactory relief to patients [7].…”