Sleep disorders and depression in patients with Parkinson's disease

Happe, Svenja; Schrödl, B.; Faltl, Margit; Müller, Christian; Auff, Eduard; Zeitlhofer, J.

doi:10.1034/j.1600-0404.2001.00024.x

Cited by 77 publications

(28 citation statements)

References 40 publications

(50 reference statements)

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“…Examining the UPDRS subscales, positive correlations were found between PLMSI and both UPDRS II and UPDRS III, suggesting an increased impairment in both daily activities and motor symptoms with worsening of PLMS. An association between PLMS (assessed by questionnaire) and severity of motor symptoms was previously observed by Happe and colleagues [30]. Our study both confirms and extends these findings utilizing PSG as an objective measure for the assessment of PLMS.…”

Section: Discussionsupporting

confidence: 91%

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Clinical correlates of periodic limb movements in sleep in Parkinson's disease

Covassin

Neikrug

Liu

et al. 2012

Journal of the Neurological Sciences

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Objective The aim of the current study was to investigate the frequency of periodic limb movements in sleep (PLMS) in Parkinson’s disease (PD) and their impact on nocturnal sleep and daytime functioning. Methods Forty-five PD patients (mean age 68.5±8.7 years; 32 males) underwent one night of polysomnography (PSG). Clinical assessment and questionnaires evaluating sleep disturbance and quality of life (QoL) were completed. Patients were divided into two groups based on their PLMS index (PLMSI): PLMSI ≥15 (PLMS+) and PLMSI <15 (PLMS−). Results There were 26 (57.8%) PD patients in the PLMS+ group and 19 (42.2%) patients in the PLMS− group. Subjective assessment revealed an association between PLMS+ status and greater PD symptom severity, more subjective sleep disturbance, and decreased QoL. All patients showed poor sleep, and no significant group differences were detected on PSG measures. Conclusion We observed that PLMS occurred frequently in PD and increased with more severe PD. Although PLMS did not affect objective sleep, it was associated with increased sleep complaints and reduced QoL. Overall, our findings support the association between PLMS and PD as well as the clinical relevance of sleep disturbances in PD.

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Section: Discussionsupporting

confidence: 91%

“…Some studies have found that PLMS are also more common in PD patients compared to healthy age-matched controls [3,29], whereas others did not detect significant differences [30,31]. …”

Section: Introductionmentioning

confidence: 99%

Clinical correlates of periodic limb movements in sleep in Parkinson's disease

Covassin

Neikrug

Liu

et al. 2012

Journal of the Neurological Sciences

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“…Previous studies indicate that OSA prevalence varies from 24 to 65% [148,149,150,151]. Contradictory evidence can be found showing both a higher prevalence of OSA in PD patients than in the general population [67,149,151] and no increased risk of OSA in PD patients [152,153].…”

Section: Sleep Disordersmentioning

confidence: 88%

Sleep-Wake Disturbances in Parkinson’s Disease: Current Evidence regarding Diagnostic and Therapeutic Decisions

Bruin

Bittencourt²,

Tufik³

2012

Eur Neurol

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Sleep disorders have been frequently reported in patients with Parkinson’s disease (PD). However, there is insufficient evidence to guide precise recommendations on some diagnostic and treatment strategies. Here, we review clinical studies dealing with sleep abnormalities in PD and present clinical recommendations. Previous studies describing insomnia, excessive daytime sleepiness, narcolepsy-like episodes, circadian changes, sleep-disordered breathing, rapid eye movement sleep behavior disorder, vivid dreams and restless legs syndrome are evaluated. Longitudinal studies associating sleep disorders with PD onset or clinical deterioration are rare: only one longitudinal study associated daytime sleepiness with PD onset. Evidence suggests that clinical investigations must include direct questioning about depressive symptoms, nocturnal cramps, pain, nocturia and nighttime off periods. A patient interview must be conducted regarding sleep symptoms, including nightmares, abnormal behavior during sleep, snoring, restless legs syndrome and daytime sleepiness. Initial evidence indicates that light therapy improves motor function and depression. Advice on sleep hygiene, the treatment of concomitant depression and the careful use of dopaminergic drugs and hypnosedative agents should be considered. To date, very few controlled studies are available to make a recommendation for the management of sleep-wake disturbances in PD.

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“…Many factors have been implicated including the use of dopaminergic therapy [2], coexisting depression [3], and more importantly the underlying disease itself [4][5][6]. Sleep disorders in PD appear to arise from a combination of neurochemical and neurodegenerative changes in central sleep regulatory centres [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Observational study of sleep-related disorders in Italian patients with Parkinson’s disease: usefulness of the Italian version of Parkinson’s disease sleep scale

et al. 2011

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Sleep disturbances are common in patients with Parkinson's disease (PD). We aimed to evaluate prevalence and severity of nighttime sleep disturbances in Italian PD patients and to validate the Italian version of the Parkinson's disease sleep scale. A total of 221 PD patients and 57 healthy controls participated in a cross-sectional study with retest. PDSS, Epworth Sleepiness Scale (ESS), Hamilton Depression Rating Scale, Unified Parkinson's Disease Rating Scale (UPDRS), and Hoehn and Yahr staging were applied. PDSS total and individual items scores from patients were significantly lower than those in controls. Internal consistency of PDSS scale was satisfactory and intraclass correlation coefficient for test-retest reliability was 0.96 for total PDSS score. A significant negative correlation was found between total PDSS and ESS scores, and between total PDSS and HDRS scores. PDSS scores were also related to UPDRS sections II, III and IV, and H&Y stage. PDSS and ESS scores were not related to levodopa equivalent dose. Daytime sleepiness, depressive symptoms and disease severity correlate with sleep disturbances in Italian PD patients. The PDSS is a valid and reliable tool to evaluate sleep disturbances in Italian patients.

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Sleep disorders and depression in patients with Parkinson's disease

Cited by 77 publications

References 40 publications

Clinical correlates of periodic limb movements in sleep in Parkinson's disease

Clinical correlates of periodic limb movements in sleep in Parkinson's disease

Sleep-Wake Disturbances in Parkinson’s Disease: Current Evidence regarding Diagnostic and Therapeutic Decisions

Observational study of sleep-related disorders in Italian patients with Parkinson’s disease: usefulness of the Italian version of Parkinson’s disease sleep scale

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