Sleep-Disordered Breathing in Pregnancy

Konstanty-Kurkiewicz, Violetta; Dzięciołowska-Baran, Edyta; Szczurowski, Jacek; Gawlikowska-Sroka, Aleksandra

doi:10.1007/5584_2021_691

Cited by 4 publications

(7 citation statements)

References 38 publications

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“…18 However, the study also showed that 69% of pregnant women had single or multiple apnea episodes, and pregnant women with higher weight gain had poorer respiratory status. 18 Pregnancy-related anatomic, physiologic, and hormonal factors can occur in different stages of pregnancy and affect the degree and severity of sleep disturbances. Some of these pregnancy changes can also cause sleep disorders or exacerbate existing sleep disorders, which can impact maternal and fetal health.…”

Section: Discussionmentioning

confidence: 90%

“…In a previous study that conducted in‐home portable sleep monitoring of pregnant women with a pre‐pregnancy BMI of 30 kg/m 2 with hypertension or diabetes before pregnancy, the prevalence of mild, moderate, and severe sleep‐disordered breathing was 21%, 6%, and 3% in the first trimester, and 35%, 7%, and 5% in the third trimester, respectively 17 . In a study of 51 women in the second trimester of pregnancy who were examined at home using pulse oximetry and the sleep‐disordered breathing questionnaire, the mean apnea‐hypopnea index (AHI) was 1.8 ± 1.8/hour, without significant difference from the general young adult female population 18 . However, the study also showed that 69% of pregnant women had single or multiple apnea episodes, and pregnant women with higher weight gain had poorer respiratory status 18 .…”

Section: Discussionmentioning

confidence: 99%

“…In a study of 51 women in the second trimester of pregnancy who were examined at home using pulse oximetry and the sleep‐disordered breathing questionnaire, the mean apnea‐hypopnea index (AHI) was 1.8 ± 1.8/hour, without significant difference from the general young adult female population 18 . However, the study also showed that 69% of pregnant women had single or multiple apnea episodes, and pregnant women with higher weight gain had poorer respiratory status 18 . Pregnancy‐related anatomic, physiologic, and hormonal factors can occur in different stages of pregnancy and affect the degree and severity of sleep disturbances.…”

Section: Discussionmentioning

confidence: 99%

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Sleep habits and problems across gestational progress in Japanese women

Kawakami

Ikegami

Komada

2023

J of Obstet and Gynaecol

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Background: Pregnancy-related anatomic, physiologic, and hormonal factors can occur at different stages of pregnancy and affect sleep disturbances. Sleep problems and habits among Japanese women across gestational stages have not been described. This study aimed to elucidate sleep problems, including a high risk of sleep-disordered breathing and sleep habits, among Japanese women across gestational progress, including postpartum. Methods: A questionnaire survey using the Pittsburgh Sleep Quality Index (PSQI) and Berlin Questionnaire was conducted for 683 pregnant women (223 in the second trimester, 453 in the third trimester) and 386 postpartum (within 1 week after delivery). Results: The total PSQI score was 5.3 [2.6] in the second trimester, 6.1 [2.8] in the third trimester, and 6.8 [3.1] in the first week postpartum. The percentage of those at high risk for sleep-disordered breathing, as determined by the Berlin Questionnaire, was 11.8% in the second trimester, 21.3% in the third trimester, and 19.2% in the first week postpartum, with the highest percentage of those at high risk in the third trimester of pregnancy. Conclusion:The PSQI total score exceeded the cut-off value in the third trimester and the first week postpartum, suggesting sleep deterioration. Therefore, it is necessary to understand and support sleep in pregnant women to ensure safe delivery, postpartum recovery, and health.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sleep habits and problems across gestational progress in Japanese women

Kawakami

Ikegami

Komada

2023

J of Obstet and Gynaecol

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“…5 Upper airway remodeling and edema during pregnancy are similarly associated with reduced inspiratory pressure which, together with reduced functional residual capacity (FRC) and chest wall compliance, may increase the risk of a pregnant woman developing OSA. 6 Decreased lung volume and FRC that cause OSA can be explained by anatomical, chemical, and neuronal factors. 7 Reduced lung volume leads to upper airway collapse, 8 storage of oxygen (O 2 ) and carbon dioxide (CO 2 ), 9 and neuronal control of upper airway muscles.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In addition, diaphragmatic elevation can be affected by an increased uterus size, thereby leading to breathing problems . Upper airway remodeling and edema during pregnancy are similarly associated with reduced inspiratory pressure which, together with reduced functional residual capacity (FRC) and chest wall compliance, may increase the risk of a pregnant woman developing OSA . Decreased lung volume and FRC that cause OSA can be explained by anatomical, chemical, and neuronal factors .…”

Section: Introductionmentioning

confidence: 99%

Tandem Mass Tag-Labeled Quantitative Proteome Analyses Identify C1R and A2M as Novel Serum Biomarkers in Pregnant Women with Obstructive Sleep Apnea

Zhang,

Yue,

Wang

et al. 2024

J. Proteome Res.

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The aim of this study was to identify serum diagnostic biomarkers associated with the severity of obstructive sleep apnea (OSA) during pregnancy. Differentially expressed proteins (DEPs) were identified in the control (C), mild (O), and moderate (MO) OSA groups (n = 3 in each group). Bioinformatics analysis was conducted to identify the underlying functions, pathways, and networks of the proteins. Receiver operating characteristic curves were used to assess the diagnostic value of the identified DEPs. The enzyme-linked immunoassay was performed to detect serum levels of the complement C1r subcomponent (C1R) and alpha-2macroglobulin (A2M) in 79 pregnant women with OSA (mild OSA [n = 32]; moderate OSA [n = 29], and severe OSA [n = 18]) and 65 healthy pregnant women without OSA. Pearson's correlation analysis was conducted to analyze the correlation between C1R and A2M levels and OSA clinicopathological factors. In total, 141 DEPs, 29 DEPs, and 103 DEPs were identified in the three groups (i.e., the mild OSA vs control group, the moderate OSA vs mild apnea group, and the moderate OSA vs control group, respectively). C1R and A2M were identified as continuously up-regulated proteins, and the levels of C1R and A2M were associated with OSA severity. C1R and A2M were found to be correlated with body mass index, systolic blood pressure, apnea−hypopnea index, oxygen desaturation index, time with saturation below 90%, and lowest SaO 2 . Adverse maternal and neonatal outcomes were observed in pregnant women with OSA. C1R and A2M have been identified as diagnostic biomarkers and are associated with the severity of OSA during pregnancy.

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Sleep disorders during pregnancy - its prevalence, characteristic and neonatal implications

Tomaszuk,

Wąsik,

Wojtuś

2024

J Educ Health Sport

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Introduction and purpose: Each phase of a woman's life, from childhood to menopause, may be associated with a variety of sleep disturbances. The pregnancy is particularly predisposed to develop sleep disorders such as insomnia, restless legs syndrome and sleep-disordered breathing, which require special management. This article reviews the most common sleep disturbances in pregnancy and discusses epidemiology, pathophysiology, maternal and fetal possible implications and therapeutic options in the pregnant population. Material and methods of research: The search was conducted using PubMed and Google Scholarship databases available to January 2024. Results: Although the exact cause of previously mentioned diseases remains uncertain, the impact of hormonal changes, the body mass before pregnancy and weight gaining during gestation on their development is highlighted by researchers. Poor sleep in pregnancy may have negative outcomes for women as well as fetuses and influence the pregnancy course. These sleeping disorders may also contribute to development of other systemic diseases. The management of sleep disturbance in pregnant patients is challenging due to the risk of teratogenicity, pharmacokinetic changes and the dynamic nature of pregnancy, thus nonpharmacologic interventions should be preferred as safer than medications. Conclusions: Sleep disturbances result in poorer quality of pregnant women’s life and have negative impact on the condition of pregnancy. Thus, this theme should create the need for additional research on the possibilities of prevention and treatment strategies of sleep disorders in pregnant women.

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Sleep-Disordered Breathing in Pregnancy

Cited by 4 publications

References 38 publications

Sleep habits and problems across gestational progress in Japanese women

Sleep habits and problems across gestational progress in Japanese women

Tandem Mass Tag-Labeled Quantitative Proteome Analyses Identify C1R and A2M as Novel Serum Biomarkers in Pregnant Women with Obstructive Sleep Apnea

Sleep disorders during pregnancy - its prevalence, characteristic and neonatal implications

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