Sleep-disordered Breathing in Children with Cardiomyopathy

Al-Saleh, Suhail; Kantor, Paul F.; Chadha, Neil K.; Tirado, Yamilet; James, Adrian L.; Narang, Indra

doi:10.1513/annalsats.201309-325oc

Cited by 22 publications

(14 citation statements)

References 51 publications

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“…We found that OSA was common in children with CHD, with an incidence of 57% in our sample, compared with a typical community prevalence of 1% to 5% in children. 25 Additionally, although central sleep apnea has been found to be common in children with cardiomyopathies 26 and adults with heart failure, 27,28 we found no cases of central sleep apnea in this sample of children with CHD. Similarly, we found no cases of nocturnal hypoxemia in our sample.…”

Section: Discussionmentioning

confidence: 55%

OSA and Neurocognitive Impairment in Children With Congenital Heart Disease

Combs

Edgin

Klewer

et al. 2020

Chest

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BACKGROUND: Children with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of OSA, which is associated with neurocognitive impairment in children without CHD. RESEARCH QUESTION: Is OSA is associated with neurocognitive impairment in children with CHD? STUDY DESIGN AND METHODS: Children aged 6 to 17 years with corrected moderate to complex CHD without syndromes that may affect neurocognition were recruited from the pediatric cardiology clinic. Participants underwent home sleep testing and neurocognitive testing, including a validated Intellectual Quotient (IQ) test as well as validated tests of memory (Paired Associates Learning test), executive function (Intra-Extra Dimensional set shift test), and attention (Simple Reaction Test) from the CANTAB neurocognitive testing battery. RESULTS: Complete results were available for 30 children. Seventeen children (57%) were found to have OSA. Total IQ was markedly lower in children with CHD and comorbid OSA compared with children with CHD without comorbid OSA (mean, 86 AE 12 vs 98 AE 11; P ¼ .01). Children with CHD and OSA did significantly worse on the Paired Associates Learning test, with a median of eight total errors (interquartile range [IQR], 2.25-15) compared with children with CHD without OSA (median total errors, 2, IQR, 1-8; P ¼ .02). INTERPRETATION: Children with CHD and comorbid OSA have impaired neurocognition compared with children with CHD without comorbid OSA. OSA may be a reversible cause of neurocognitive impairment in children with CHD. Further research is needed to evaluate the effects of OSA treatment on neurocognitive impairment in children with CHD.

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Section: Discussionmentioning

confidence: 55%

OSA and Neurocognitive Impairment in Children With Congenital Heart Disease

Combs

Edgin

Klewer

et al. 2020

Chest

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“…has been observed in both adult and pediatric populations. Among the pediatric population, a pilot study [17] with overnight polysomnography (PSG) showed that 48% of 21 patients had SDB. Among these, 24% had central sleep apnea (CSA) while the remaining had OSA.…”

Section: Prevalence Of Sleep Disordered Breathing (Sdb) In Hypertrophmentioning

confidence: 99%

Sleep Disordered Breathing in Hypertrophic Cardiomyopathy—Current State and Future Directions

Venkataraman

Karim

Rajendran

et al. 2020

JCM

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Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and sleep disordered breathing (SDB) is a treatable risk factor that has been seen to occur concurrently, and is known to propagate mortality and morbidity in a number of cardiovascular disease states including heart failure, and indeed hypertrophic cardiomyopathy. In this review, we summarize past studies that explored the simultaneous occurrence of HCM and SDB, and the pathophysiology of SDB in relation to heart failure, arrhythmias, cardiac ischemia and pulmonary hypertension in HCM. The current therapeutic modalities, with the effect of obstructive sleep apnea (OSA) treatment on HCM, are then discussed along with potential future directions.

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“…Medical therapy had included Digoxin, Carvedilol, Ramipril, and Spironolactone. He underwent a standard PSG according to international guidelines at the time of admission that was part of a prospective observational study to describe sleep disordered breathing (SDB) in children with known cardiomyopathy, the group data of which have been published elsewhere [ 7 ]. Significant findings in the PSG were a significantly elevated central apnea-hypopnea index (CAHI) of 17 events/hour with CSR similar to that described in adults with CSR ( Figure 1 ).…”

Section: Case Presentationmentioning

confidence: 99%

Impact of Heart Transplantation on Cheyne-Stokes Respiration in a Child

Al-Saleh

Kantor

Narang

2016

Case Reports in Pediatrics

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Sleep disordered breathing is well described in adults with heart failure but not in pediatric population. We describe a 13-year-old Caucasian male with severe heart failure related to dilated cardiomyopathy who demonstrated polysomnographic features of Cheyne-Stokes respiration, which completely resolved following cardiac transplantation. Cheyne-Stokes respiration in children with advanced heart failure and its resolution after heart transplant can be observed similar to adults.

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Sleep-disordered Breathing in Children with Cardiomyopathy

Cited by 22 publications

References 51 publications

OSA and Neurocognitive Impairment in Children With Congenital Heart Disease

OSA and Neurocognitive Impairment in Children With Congenital Heart Disease

Sleep Disordered Breathing in Hypertrophic Cardiomyopathy—Current State and Future Directions

Impact of Heart Transplantation on Cheyne-Stokes Respiration in a Child

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