Sleep-disordered breathing in children with chronic kidney disease

Amin, Reshma; Sharma, Neha; Almokali, Khamisa; Sayal, Priya; Al-Saleh, Suhail; Narang, Indra; Harvey, Elizabeth

doi:10.1007/s00467-015-3155-x

Cited by 24 publications

(16 citation statements)

References 49 publications

(68 reference statements)

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“…Previously, one similar study was published by Amin et al among non‐obese, dialysis‐dependent, and non‐dependent children and they found a high prevalence of SDB (overall frequency 40.0%) similarly to us.…”

Section: Discussionsupporting

confidence: 84%

“…Although studies carried out in the adult setting advocate for the high prevalence and the clinical importance of SDB in renal transplant patients, the condition in pediatric population has not been well described. Previous studies among pediatric CKD patients showed a high prevalence of SDB . Most of these studies investigated heterogeneous patient groups, and the applied methods consisted of questionnaires and actigraphy.…”

Section: Introductionmentioning

confidence: 99%

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Cardiometabolic correlates of sleep‐disordered breathing in renal transplant children

Lendvai

Pásti

Szeifert

et al. 2019

Pediatric Transplantation

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Sleep‐disordered breathing, a prevalent condition among adult renal transplant (RTx) recipients, has become an established independent risk factor of MetS, and furthermore, it might contribute to increased CV risk. Despite the proven correlations in adults, there is a lack of evidence for its significance in the pediatric RTx population. In this study, we aimed at assessing the prevalence and the clinical correlates of SDB in RTx children. Data of 13 patients (age [mean ± SD]: 14.2 ± 2.7 years) were analyzed. SDB was evaluated by PSG, as severity score OAHI was applied. Carbohydrate metabolism was characterized by OGTT, whereas CV status was studied by ABPM. Three composite end‐points were calculated as sum of z‐scores: daytime systolic and diastolic BP; nighttime systolic and diastolic BP; and glucose and insulin levels at 120 minutes. Eight patients (61.5%) were diagnosed with SDB of whom five patients (38.5%) had moderate or severe SDB. In linear regression analysis, OAHI during REM was associated with the CV variables (daytime BP P = 0.032, ß = 0.748; nighttime BP P = 0.041, ß = 0.715), and the correlations remained significant after adjustments for BMI. However, we did not confirm a significant association with the metabolic variables. The prevalence of SDB was high, and its severity during REM was a predictor of the BP suggesting that RTx children with SDB might be at risk of developing CV complications, especially HTN similarly to adults.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Cardiometabolic correlates of sleep‐disordered breathing in renal transplant children

Lendvai

Pásti

Szeifert

et al. 2019

Pediatric Transplantation

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“…The previous studies in the literature that showed increased prevalence of OSA in children with various chronic diseases supports this view. For example, the prevalence of OSA has been found as 40% in children with chronic renal failure (16). The prevalance of OSA has been reported as 52% in patients with primary ciliary dyskinesia and 19% in patients with bronchiolitis obliterans (17, 18).…”

Section: Discussionmentioning

confidence: 99%

“…The Children's Sleep Habit Questionnaire is a questionnaire composed of 22 questions, which was developed by Chervin et al (16), that is used in evaluation of SDB in children aged between 2 and 18 years. The reliability and validity study of this questionnaire for Turkish children was performed by Yüksel et al (7).…”

Section: The Children's Sleep Habit Questionnairementioning

confidence: 99%

Clinical and polysomnographic features of children evaluated with polysomnography in pediatric sleep laboratory

et al. 2017

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Aim: Sleep disordered breathing is a common problem in childhood that encompasses a spectrum of disorders extending from primary snoring to obstructive sleep apnea. This study aims to investigate the results of children undergoing evaluation with polysomnography in the sleep laboratory of a tertiary care hospital. Material and Methods:Demographic and clinical features as well as sleep associated symptoms, scores of pediatric sleep questionnaire and Pittsburgh sleep quality index and polysomnography results are retrospectively evaluated.Results: Totally 131 patients were evaluated, of which 47.3% (n=62) were females and 52.7% (n=69) were males. Mean age was 101.85±59.15 months at the time of the study. Fifty percent (n=59) of patients complained of snoring and 43.7% (n=52) of patients complained of apnea during sleep. Mean obstructive hypopnea-apnea index was 5.12±11.72. Mean obstructive hypopnea-apnea index of snorers (6.93±13.53) was significantly higher than the mean obstructive hypopnea-apnea index of nonsnorers (2.32±5.43) (p=0.011). Mean obstructive hypopnea-apnea index of patients experiencing apnea during sleep (7.52±14.25) was significantly higher than the mean obstructive hypopnea-apnea index of the children who do not experience apnea (2.61±5.84) (p=0.008). No significant correlation was observed between obstructive hypopnea-apnea index and scores of pediatric sleep questionnaire and Pittsburgh sleep quality index. The prevalence of obstructive sleep apnea was 33.6% (n=44). Forty nine patients (39.8%) were treated after polysomnography. Frequently suggested treatment options were noninvasive mechanical ventilation (n=23, 46.9%), intranasal steroid (n=15, 30.6%), montelukast (n=11, 22.4%) and adenotonsillectomy (n=9, 18.4%). Conclusions:Polysomnography is the gold standard in the diagnosis of sleep disordered breathing in children. Pediatricians should be able to recognize early signs and symptoms of sleep disordered breathing and refer the patients in risk to centers where evaluation with polysomnography is available. (Turk Pediatri Ars 2017; 52: 23-9)

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“…Amin et al published the first study on PSG in 19 dialysis‐dependent children aged 5.4–16.5 years. Similarly to reports in adults, they found a very high prevalence (37%) of SDB in children with chronic kidney disease, equally distributed between OSAS and CSAS.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Pulmonologyyear in review 2015: Part 2

Praud

2016

Pediatr Pulmonol.

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Pediatric Pulmonology covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review (Part 2) covers articles on sleep-disordered breathing. Pediatr Pulmonol. 2016;51:740-746. © 2016 Wiley Periodicals, Inc.

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Sleep-disordered breathing in children with chronic kidney disease

Abstract: There was a high prevalence of SDB in this cohort of children with CKD. The PSG and validated sleep questionnaires yielded discordant results, reinforcing the limitations of diagnosing SDB in the CKD population based solely on sleep questionnaires.

Cited by 24 publications

References 49 publications

Cardiometabolic correlates of sleep‐disordered breathing in renal transplant children

Cardiometabolic correlates of sleep‐disordered breathing in renal transplant children

Clinical and polysomnographic features of children evaluated with polysomnography in pediatric sleep laboratory

Pediatric Pulmonologyyear in review 2015: Part 2

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