Sleep-disordered breathing children

Huang, Ya‐Ping; Zou, Yandun; Mai, F; Zhang, X; Liu, Y; Lin, Xue‐Jun

doi:10.1007/s00106-016-0120-3

Cited by 5 publications

(1 citation statement)

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“…As nasal nitric oxide (nNO) is several times higher than FeNO [5], we hypothesize the difference of nNO level in OSA patients, and the health adults would also be much greater. Unfortunately, only six researches about nNO in patients with OSA were published, and among them, three were in pediatric OSA [6–8]; the other three were in adults with different methods of measuring nNO [9–11]. The levels of nNO in patients with OSA varied widely (from 28.4 to 610.03 ppb) in different studies, and all of these studies included less than 50 OSA patients.…”

Section: Introductionmentioning

confidence: 99%

Measurement of fractional exhaled nitric oxide and nasal nitric oxide in male patients with obstructive sleep apnea

et al. 2018

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Objective Airway inflammation plays an important role in obstructive sleep apnea (OSA); exhaled nitric oxide is regarded as a noninvasive marker of airway inflammation. The aim of this study was to evaluate fractional exhaled nitric oxide (FeNO) and nasal nitric oxide (nNO) in patients with OSA. Methods Seventy-five patients with OSA and 30 health controls were enrolled in this study. FeNO and nNO were measured before and after sleep. Nasal lavage was performed in 31 non-smoking individuals immediately after NO measurement in the morning. The sample of nasal lavage was taken for cell classification and analyzing interleukin 6 (IL-6) and interleukin 8 (IL-8). Results Both FeNO and nNO were significantly higher in OSA (before sleep FeNO 21.08 ± 8.79 ppb vs.16.90 ± 6.86 ppb, p = 0.022; after sleep FeNO 25.57 ± 15.58 ppb vs.18.07 ± 6.25 ppb, p = 0.003; before sleep nNO 487.03 ± 115.83 ppb vs. 413.37 ± 73.10 ppb, p = 0.001; after sleep nNO 550.07 ± 130.24 ppb vs. 460.43 ± 109.77 ppb, p < 0.001). Furthermore, in non-smoking OSA, nNO levels were positively correlated with apnea hypopnea index (AHI) and average decrease of pulse arterial oxygen saturation (SpO 2 ); after sleep, nNO was also positively associated to recording time with SpO 2 < 90% and negatively associated to minimum SpO 2 . Both before and after sleep nNO levels were positively correlated with the percentage of neutrophils in nasal lavage ( r = 0.528, p = 0.014; r = 0.702, p < 0.001, respectively). Additionally, before sleep nNO was also positively associated with IL-6 ( r = 0.586, p = 0.005) and IL-8 ( r = 0.520, p = 0.016) concentration. Conclusion This study sustains the presence of airway inflammation in OSA patients with the increase of FeNO and nNO. The data suggests nNO might have greater value than FeNO since it positively correlated with OSA severity, and nNO is a potential bio-marker of nasal inflammation in non-smoking OSA patients. Electronic supplementary material The online version of this article (10.1007/s11325-018-1760-1) contains supplementary material, which is available to authorized users.

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