Sleep-Disordered Breathing and the Risk of Venous Thromboembolism

Alnas, Majd; Matta, Fadi; Khawaja, Imran

doi:10.1378/chest.136.4_meetingabstracts.67s-d

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“…Nevertheless, this negative finding may be explained by the fact that hip or knee surgery is conventionally considered an outmost prothrombotic condition, which may overwhelm any other risk factor and hence decrease the potential contribution of sleep disturbances in the pathogenesis of VTE in patients undergoing orthopaedic surgery (32,33). Another large observational study has been published in form of an abstract in 2009, but not including specific data on obstructive sleep apnea (34). Interestingly, the authors extracted data from the US National Hospital Discharge Survey (NHDS) between the years 1979 and 2005 to establish the relationship between SDB and VTE, and also found a significant association between these two conditions (relative risk, 1.72; 95 % CI, 1.70-1.74).…”

Section: Discussionmentioning

confidence: 99%

Sleep apnea and venous thromboembolism

Lippi¹,

Mattiuzzi²,

Franchini³

2015

Thromb Haemost

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SummaryRecent evidence suggests that obstructive sleep apnea is a significant and independent risk factor for a number of cardiovascular disorders. Since the association between obstructive sleep apnea and cardiovascular disease is mediated by endothelial dysfunction, hypercoagulability and platelet abnormalities, we sought to investigate whether sleep apnea may also be considered a risk factor for venous thromboembolism (VTE). We carried out an electronic search in Medline and Scopus using the keywords "apnea" OR "apnoea" AND "venous thromboembolism" OR "deep vein thrombosis" OR "pulmonary embolism" in "Title/Abstract/Keywords", with no language or date restriction. Fifteen studies (8 case-control, 4 retrospective observational, 2 prospective case-control and 1 prospective observational) were finally selected for this systematic review. In all studies except one (14/15; 93 %), obstructive sleep apnea was found to be an independent risk factor for VTE, either deep-vein thrombosis (DVT) or pulmonary embolism (PE). In the two prospective case-control studies the risk of DVT or PE was found to be two-to three-fold higher in patients with obstructive sleep apnea than in those without. In conclusion, the current epidemiological evidence supports the hypothesis that obstructive sleep apnea may be an independent risk factor for VTE.

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Section: Discussionmentioning

confidence: 99%