Sleep-Disordered Breathing and Poor Functional Outcome After Stroke

Good, David C.; Henkle, Joseph; Gelber, David A.; Welsh, Jennifer; Verhulst, Steve

doi:10.1161/01.str.27.2.252

Cited by 364 publications

(257 citation statements)

References 38 publications

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“…Dyken et al 218 noted that patients after stroke have a high prevalence of OSA and that those stroke patients with OSA had a markedly diminished poststroke survival. Similar findings regarding survival and limited rehabilitation success 219,220 have been reported by other investigators. Direct studies of the interaction between sleep apnea and rehabilitation outcome after stroke that used overnight pulse oximetry to evaluate the respiratory disturbance index suggested that hypoxic events during sleep predicted poorer recovery, especially in patients with poor function at admission.…”

Section: Treatment Of Osa: Effects On Strokesupporting

confidence: 91%

Sleep Apnea and Cardiovascular Disease

et al. 2008

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Section: Treatment Of Osa: Effects On Strokesupporting

confidence: 91%

Sleep Apnea and Cardiovascular Disease

et al. 2008

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“…Mechanisms have been postulated to account for possible increased atherogenesis in OSAS [26], and it has recently been reported that patients with coexisting CHD and OSAS are at increased risk of apnoeaassociated ischaemic events [27]. An association of snoring and OSAS is also reported with stroke and possibly stroke prognosis [28], though studying patients following stroke is made difficult by the fact that stroke itself may induce or worsen OSAS. The findings in this paper are in general agreement with these previous reports but do not help distinguish a separate risk from OSAS independent of other confounding variables.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome

Kiely¹,

McNicholas²

2000

Eur Respir J

166

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Cardiovascular disorders are common in patients with obstructive sleep apnoea syndrome (OSAS) but there is debate as to whether OSAS is an independent risk factor for their development, since OSAS may be associated with other disorders and risk factors that predispose to cardiovascular disease.In an effort to quantify the risk of OSAS patients for cardiovascular disease arising from these other factors, the authors assessed the future risk for cardiovascular disease among a group of 114 consecutive patients with established OSAS prior to nasal continuous positive airway pressure therapy, using an established method of risk prediction employed in the Framingham studies.Patients were 100 males, aged (meanSD) 529.0 yrs, and 14 females, aged 5110.4 yrs, with an apnoea/hypopnoea index of 4522 . h -1 . Based on either a prior diagnosis, or a mean of three resting blood pressure recordings >140 mmHg systolic and/or 90 diastolic, 68% of patients were hypertensive. Only 18% were current smokers, while 16% had either diabetes mellitus or impaired glucose tolerance, and 63% had elevated fasting cholesterol and/or triglyceride levels. The estimated 10-yr risk of a coronary heart disease (CHD) event in males was (meanSEM) 13.90.9%, 95% confidence interval (95% CI) 12.1±16.0, and for a stroke was 12.31.4%; 95% CI 9.4± 15.1, with a combined 10 yr risk for stroke and CHD events of 32.92.7%; 95% CI 27.8±38.5 in males aged >53 yrs.These findings indicate that obstructive sleep apnoea syndrome patients are at high risk of future cardiovascular disease from factors other than obstructive sleep apnoea syndrome, and may help explain the difficulties in identifying a potential independent risk from obstructive sleep apnoea syndrome.

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“…But in OSA patients who are said to be nondippers, they have absent fall in nocturnal BP (Leung et al, 2001). Studies also suggest an increase in the risk of myocardial infarction and stroke in untreated OSAHS (Good et al, 1996;Leung et al, 2001;Leung, 2009), Bblockers have been reported to be the most effective among antihypertensive agents, in lowering daytime BP in hypertensive OSA patients as sympathetic overactivity is involved. However antihypertensive medications have little effect on nocturnal BP in OSA, possibly because they do not reduce OSA (Kraiczi et al, 2000).…”

Section: Associated Featuresmentioning

confidence: 99%

Modalities of treatment for sleep disordered breathing

Tin¹,

Ohn²

2016

Asian J. Med. Biol. Res

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Abstract:Sleep disordered breathing is a spectrum of diseases that includes snoring, upperairway resistance syndrome and obstructive sleep apnea. It occurs more in obese males, resulting in hypertension and cardiac complications if untreated. There are various treatments, conservatively and surgically, starting from simple tonsillectomy to multi-level surgeries and multi discipline. Literature review was carried out on the pathophysiology, clinical presentation, complications, diagnosis and various treatments, using internet Google, search PubMed. Additional information was obtained by cross referencing, using text and journals in the medical libraries.

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Sleep-Disordered Breathing and Poor Functional Outcome After Stroke

Cited by 364 publications

References 38 publications

Sleep Apnea and Cardiovascular Disease

Sleep Apnea and Cardiovascular Disease

Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome

Modalities of treatment for sleep disordered breathing

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