Sleep-Disordered Breathing and Excessive Daytime Sleepiness

He, Ken; Kapur, Vishesh K.

doi:10.1016/j.jsmc.2017.03.010

Cited by 50 publications

(31 citation statements)

References 140 publications

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“…As reported previously, we also found that many OSA patients do not report EDS (He & Kapur, 2017). Importantly, many individuals with higher OSA severity (AHI > 30 events/hr) reported low levels of EDS.…”

Section: Discussionsupporting

confidence: 88%

The prevalence of excessive sleepiness is higher in shift workers than in patients with obstructive sleep apnea

Reis

Staats

Pellegrino

et al. 2020

Journal of Sleep Research

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Shift work is any work schedule outside conventional daytime hours that implies workers are on duty for time periods that supposedly should be used for sleep according to their biological rhythm. This includes very early mornings, and evening and night shifts. These shifts can be fixed or rotating (Kecklund & Axelsson, 2016). Disrupted sleep is one of the known consequences of shift work, leading to fatigue, insomnia symptoms and excessive daytime sleepiness (EDS) (Booker,

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Section: Discussionsupporting

confidence: 88%

The prevalence of excessive sleepiness is higher in shift workers than in patients with obstructive sleep apnea

Reis

Staats

Pellegrino

et al. 2020

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

“…In addition, a divergence between subjectively percieved and objectively measured sleepiness is often observed, not least because of the diverse vocabulary for the feeling of drowsiness (sleepiness, tiredness, unrested, drowsiness, fatigue, etc.) [6,20].…”

Section: Discussionmentioning

confidence: 99%

“…Excessive daytime sleepiness (EDS) has been considered one of the cardinal symptoms of OSA and can result in reduced vigilance. The underlying pathophysiology in this regard is highly complex [6,20]. Cortical arousals are observed near the end of the vast majority of obstructive events and therefore have a fragmentary impact on the macrostructure of sleep [3].…”

mentioning

confidence: 99%

Microstructure of cortical activity during sleep reflects respiratory events and state of daytime vigilance

et al. 2019

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“…Sleep-related breathing disorders, ranging from habitual snoring to increased upper airway resistance syndrome to sleep apnea, are now recognized as major health problems [88]. The majority of patients with sleep-related breathing disorders have excessive daytime sleepiness and tiredness.…”

Section: Sleep Disorder Circadian Rhythm Disorder and Mirna Regulationmentioning

confidence: 99%

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

et al. 2020

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Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, evidence is emerging that additional non-coding RNA-based mechanisms are also required to maintain proper clock function. MicroRNA is an especially important factor that plays critical roles in regulating circadian rhythm as well as many other physiological functions. Circadian misalignment not only disturbs the sleep/wake cycle and rhythmic physiological activity but also contributes to the development of various diseases, such as sleep disorders and neurodegenerative diseases. The patient with neurodegenerative diseases often experiences profound disruptions in their circadian rhythms and/or sleep/wake cycles. In addition, a growing body of recent evidence implicates sleep disorders as an early symptom of neurodegenerative diseases, and also suggests that abnormalities in the circadian system lead to the onset and expression of neurodegenerative diseases. The genetic mutations which cause the pathogenesis of familial neurodegenerative diseases have been well studied; however, with the exception of Huntington’s disease, the majority of neurodegenerative diseases are sporadic. Interestingly, the dysfunction of microRNA is increasingly recognized as a cause of sporadic neurodegenerative diseases through the deregulated genes related to the pathogenesis of neurodegenerative disease, some of which are the causative genes of familial neurodegenerative diseases. Here we review the interplay of circadian rhythm disruption, sleep disorders and neurodegenerative disease, and its relation to microRNA, a key regulator of cellular processes.

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Sleep-Disordered Breathing and Excessive Daytime Sleepiness

Cited by 50 publications

References 140 publications

The prevalence of excessive sleepiness is higher in shift workers than in patients with obstructive sleep apnea

The prevalence of excessive sleepiness is higher in shift workers than in patients with obstructive sleep apnea

Microstructure of cortical activity during sleep reflects respiratory events and state of daytime vigilance

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

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